Prognosis Impact of Diabetes in Elderly Women and Men with Non-ST Elevation Acute Coronary Syndrome

Few studies have addressed to date the interaction between sex and diabetes mellitus (DM) in the prognosis of elderly patients with non-ST-segment elevation acute coronary syndrome (NSTEACS). Our aim was to address the role of DM in the prognosis of non-selected elderly patients with NSTEACS accordi...

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Autores: Díez Villanueva, Pablo, García Acuña, José María, Raposeiras Roubín, Sergio, Barrabés Riu, José Antonio, Cordero Fort, Alberto, Martínez Sellés Oliveria Soares, Manuel, Bardají, Alfredo, Marín, Francisco, Ruiz Nodar, Juan Miguel, Sanchís, Juan, Et al.
Formato: artículo
Fecha de publicación:2021
País:España
Recursos:Universidad Europea (UEM)
Repositorio:ABACUS. Repositorio de Producción Científica
Idioma:inglés
OAI Identifier:oai:abacus.universidadeuropea.com:11268/11491
Acesso em linha:http://hdl.handle.net/11268/11491
Access Level:acceso abierto
Palavra-chave:Diabetes mellitus tipo 2
Infarto del miocardio sin elevación del ST
Enfermedad cardiovascular
Anciano
Mujer
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spelling Prognosis Impact of Diabetes in Elderly Women and Men with Non-ST Elevation Acute Coronary SyndromeDíez Villanueva, PabloGarcía Acuña, José MaríaRaposeiras Roubín, SergioBarrabés Riu, José AntonioCordero Fort, AlbertoMartínez Sellés Oliveria Soares, ManuelBardají, AlfredoMarín, FranciscoRuiz Nodar, Juan MiguelSanchís, JuanEt al.Diabetes mellitus tipo 2Infarto del miocardio sin elevación del STEnfermedad cardiovascularAncianoMujerFew studies have addressed to date the interaction between sex and diabetes mellitus (DM) in the prognosis of elderly patients with non-ST-segment elevation acute coronary syndrome (NSTEACS). Our aim was to address the role of DM in the prognosis of non-selected elderly patients with NSTEACS according to sex. A retrospective analysis from 11 Spanish NSTEACS registries was conducted, including patients aged ≥70 years. The primary end point was one-year all-cause mortality. A total of 7211 patients were included, 2,770 (38.4%) were women, and 39.9% had DM. Compared with the men, the women were older (79.95 ± 5.75 vs. 78.45 ± 5.43 years, p < 0.001) and more often had a history of hypertension (77% vs. 83.1%, p < 0.01). Anemia and chronic kidney disease were both more common in women. On the other hand, they less frequently had a prior history of arteriosclerotic cardiovascular disease or comorbidities such as peripheral artery disease and chronic pulmonary disease. Women showed a worse clinical profile on admission, though an invasive approach and in-hospital revascularization were both more often performed in men (p < 0.001). At a one-year follow-up, 1090 patients (15%) had died, without a difference between sexes. Male sex was an independent predictor of mortality (HR = 1.15, 95% CI 1.01 to 1.32, p = 0.035), and there was a significant interaction between sex and DM (p = 0.002). DM was strongly associated with mortality in women (HR: 1.45, 95% CI = 1.18-1.78; p < 0.001), but not in men (HR: 0.98, 95% CI = 0.84-1.14; p = 0.787). In conclusion, DM is associated with mortality in older women with NSTEACS, but not in men.20222022-07-1620212021-01-0120212021-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/11268/11491reponame:ABACUS. Repositorio de Producción Científicainstname:Universidad Europea (UEM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 International (CC BY 4.0)https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:abacus.universidadeuropea.com:11268/114912026-06-11T12:41:27Z
dc.title.none.fl_str_mv Prognosis Impact of Diabetes in Elderly Women and Men with Non-ST Elevation Acute Coronary Syndrome
title Prognosis Impact of Diabetes in Elderly Women and Men with Non-ST Elevation Acute Coronary Syndrome
spellingShingle Prognosis Impact of Diabetes in Elderly Women and Men with Non-ST Elevation Acute Coronary Syndrome
Díez Villanueva, Pablo
Diabetes mellitus tipo 2
Infarto del miocardio sin elevación del ST
Enfermedad cardiovascular
Anciano
Mujer
title_short Prognosis Impact of Diabetes in Elderly Women and Men with Non-ST Elevation Acute Coronary Syndrome
title_full Prognosis Impact of Diabetes in Elderly Women and Men with Non-ST Elevation Acute Coronary Syndrome
title_fullStr Prognosis Impact of Diabetes in Elderly Women and Men with Non-ST Elevation Acute Coronary Syndrome
title_full_unstemmed Prognosis Impact of Diabetes in Elderly Women and Men with Non-ST Elevation Acute Coronary Syndrome
title_sort Prognosis Impact of Diabetes in Elderly Women and Men with Non-ST Elevation Acute Coronary Syndrome
dc.creator.none.fl_str_mv Díez Villanueva, Pablo
García Acuña, José María
Raposeiras Roubín, Sergio
Barrabés Riu, José Antonio
Cordero Fort, Alberto
Martínez Sellés Oliveria Soares, Manuel
Bardají, Alfredo
Marín, Francisco
Ruiz Nodar, Juan Miguel
Sanchís, Juan
Et al.
author Díez Villanueva, Pablo
author_facet Díez Villanueva, Pablo
García Acuña, José María
Raposeiras Roubín, Sergio
Barrabés Riu, José Antonio
Cordero Fort, Alberto
Martínez Sellés Oliveria Soares, Manuel
Bardají, Alfredo
Marín, Francisco
Ruiz Nodar, Juan Miguel
Sanchís, Juan
Et al.
author_role author
author2 García Acuña, José María
Raposeiras Roubín, Sergio
Barrabés Riu, José Antonio
Cordero Fort, Alberto
Martínez Sellés Oliveria Soares, Manuel
Bardají, Alfredo
Marín, Francisco
Ruiz Nodar, Juan Miguel
Sanchís, Juan
Et al.
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv Diabetes mellitus tipo 2
Infarto del miocardio sin elevación del ST
Enfermedad cardiovascular
Anciano
Mujer
topic Diabetes mellitus tipo 2
Infarto del miocardio sin elevación del ST
Enfermedad cardiovascular
Anciano
Mujer
description Few studies have addressed to date the interaction between sex and diabetes mellitus (DM) in the prognosis of elderly patients with non-ST-segment elevation acute coronary syndrome (NSTEACS). Our aim was to address the role of DM in the prognosis of non-selected elderly patients with NSTEACS according to sex. A retrospective analysis from 11 Spanish NSTEACS registries was conducted, including patients aged ≥70 years. The primary end point was one-year all-cause mortality. A total of 7211 patients were included, 2,770 (38.4%) were women, and 39.9% had DM. Compared with the men, the women were older (79.95 ± 5.75 vs. 78.45 ± 5.43 years, p < 0.001) and more often had a history of hypertension (77% vs. 83.1%, p < 0.01). Anemia and chronic kidney disease were both more common in women. On the other hand, they less frequently had a prior history of arteriosclerotic cardiovascular disease or comorbidities such as peripheral artery disease and chronic pulmonary disease. Women showed a worse clinical profile on admission, though an invasive approach and in-hospital revascularization were both more often performed in men (p < 0.001). At a one-year follow-up, 1090 patients (15%) had died, without a difference between sexes. Male sex was an independent predictor of mortality (HR = 1.15, 95% CI 1.01 to 1.32, p = 0.035), and there was a significant interaction between sex and DM (p = 0.002). DM was strongly associated with mortality in women (HR: 1.45, 95% CI = 1.18-1.78; p < 0.001), but not in men (HR: 0.98, 95% CI = 0.84-1.14; p = 0.787). In conclusion, DM is associated with mortality in older women with NSTEACS, but not in men.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021-01-01
2021
2021-01-01
2022
2022-07-16
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/11268/11491
url http://hdl.handle.net/11268/11491
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International (CC BY 4.0)
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International (CC BY 4.0)
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:ABACUS. Repositorio de Producción Científica
instname:Universidad Europea (UEM)
instname_str Universidad Europea (UEM)
reponame_str ABACUS. Repositorio de Producción Científica
collection ABACUS. Repositorio de Producción Científica
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.301603

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