Optimization of Xanthatin Extraction from Xanthium spinosum L. and its cytotoxic, anti-angiogenesis and antiviral properties

The aqueous extraction of the sesquiterpene lactone xanthatin from Xanthium spinosum L. favours the conversion of xanthinium to xanthatin via the loss of acetic acid. The cytotoxic (Hep-G2 and L1210 human cell lines) and antiviral activities of isolated xanthatin are established. This natural compou...

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Detalles Bibliográficos
Autores: Romero, M., Zanuy, M., Rosell, E., Cascante i Serratosa, Marta, Piulats, Josep M., Font Bardia, Ma. Mercedes, Balzirini, J., de Clercq, E., Pujol Dilmé, M. Dolors
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2015
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/164558
Acceso en línea:https://hdl.handle.net/2445/164558
Access Level:acceso abierto
Palabra clave:Plantes medicinals
Medicaments antivírics
Radiocristal·lografia
Medicinal plants
Antiviral agents
X-ray crystallography
Descripción
Sumario:The aqueous extraction of the sesquiterpene lactone xanthatin from Xanthium spinosum L. favours the conversion of xanthinium to xanthatin via the loss of acetic acid. The cytotoxic (Hep-G2 and L1210 human cell lines) and antiviral activities of isolated xanthatin are established. This natural compound shows significant cytotoxicity against the Hep-G2 cell line and our experimental results reveal its strong anti-angiogenesis capacity in vitro. The structure of xanthatin is determined by spectroscopic methods and for the first time confirmed by X-ray diffraction.

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