An Overview of the Potential for Pharmacokinetic Interactions Between Drugs and Cannabis Products in Humans

Cannabis is the most commonly used illicit substance worldwide. Recent years have seen an increase in cannabis consumption, and with new approvals and therapeutic indications, there are challenges in minimizing the risks and interactions between cannabis-based products, cannabis prescription drugs,...

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Autores: Caicedo di Filippo, Dolly Andrea|||0009-0009-6523-0265, Pérez-Mañá, Clara|||0000-0001-6343-6918, Farré Albaladejo, Magí|||0000-0001-8338-7543, Papaseit, Esther|||0000-0003-2620-4274
Tipo de recurso: artículo
Fecha de publicación:2025
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:310447
Acceso en línea:https://ddd.uab.cat/record/310447
https://dx.doi.org/urn:doi:10.3390/pharmaceutics17030319
Access Level:acceso abierto
Palabra clave:Cannabis
Tetrahydrocannabinol
THC
Cannabidiol
CBD
Drug interactions
Medicines
Pharmacokinetics
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spelling An Overview of the Potential for Pharmacokinetic Interactions Between Drugs and Cannabis Products in HumansCaicedo di Filippo, Dolly Andrea|||0009-0009-6523-0265Pérez-Mañá, Clara|||0000-0001-6343-6918Farré Albaladejo, Magí|||0000-0001-8338-7543Papaseit, Esther|||0000-0003-2620-4274CannabisTetrahydrocannabinolTHCCannabidiolCBDDrug interactionsMedicinesPharmacokineticsCannabis is the most commonly used illicit substance worldwide. Recent years have seen an increase in cannabis consumption, and with new approvals and therapeutic indications, there are challenges in minimizing the risks and interactions between cannabis-based products, cannabis prescription drugs, other approved prescription drugs, and other substances of abuse. Thus, identifying the enzymes metabolizing cannabinoid drugs and their relationship with other prescription drugs is crucial for understanding the potential interactions and effects of their simultaneous use. This article offers a comprehensive review of cannabis and the pharmacokinetic interactions between cannabis products, cannabis prescription drugs, and other approved prescription drugs, as well as other substances of abuse. It also compiles existing evidence of these interactions and describes the clinical outcomes associated with the inhibition or induction of various enzymes.Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia 22025-01-0120252025-01-01Article de revisióhttp://purl.org/coar/resource_type/c_dcae04bcVoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/310447https://dx.doi.org/urn:doi:10.3390/pharmaceutics17030319reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengInstituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI20/00804Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI24/00660Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2021/SGR-00945open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:3104472026-06-06T12:50:31Z
dc.title.none.fl_str_mv An Overview of the Potential for Pharmacokinetic Interactions Between Drugs and Cannabis Products in Humans
title An Overview of the Potential for Pharmacokinetic Interactions Between Drugs and Cannabis Products in Humans
spellingShingle An Overview of the Potential for Pharmacokinetic Interactions Between Drugs and Cannabis Products in Humans
Caicedo di Filippo, Dolly Andrea|||0009-0009-6523-0265
Cannabis
Tetrahydrocannabinol
THC
Cannabidiol
CBD
Drug interactions
Medicines
Pharmacokinetics
title_short An Overview of the Potential for Pharmacokinetic Interactions Between Drugs and Cannabis Products in Humans
title_full An Overview of the Potential for Pharmacokinetic Interactions Between Drugs and Cannabis Products in Humans
title_fullStr An Overview of the Potential for Pharmacokinetic Interactions Between Drugs and Cannabis Products in Humans
title_full_unstemmed An Overview of the Potential for Pharmacokinetic Interactions Between Drugs and Cannabis Products in Humans
title_sort An Overview of the Potential for Pharmacokinetic Interactions Between Drugs and Cannabis Products in Humans
dc.creator.none.fl_str_mv Caicedo di Filippo, Dolly Andrea|||0009-0009-6523-0265
Pérez-Mañá, Clara|||0000-0001-6343-6918
Farré Albaladejo, Magí|||0000-0001-8338-7543
Papaseit, Esther|||0000-0003-2620-4274
author Caicedo di Filippo, Dolly Andrea|||0009-0009-6523-0265
author_facet Caicedo di Filippo, Dolly Andrea|||0009-0009-6523-0265
Pérez-Mañá, Clara|||0000-0001-6343-6918
Farré Albaladejo, Magí|||0000-0001-8338-7543
Papaseit, Esther|||0000-0003-2620-4274
author_role author
author2 Pérez-Mañá, Clara|||0000-0001-6343-6918
Farré Albaladejo, Magí|||0000-0001-8338-7543
Papaseit, Esther|||0000-0003-2620-4274
author2_role author
author
author
dc.contributor.none.fl_str_mv Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia
dc.subject.none.fl_str_mv Cannabis
Tetrahydrocannabinol
THC
Cannabidiol
CBD
Drug interactions
Medicines
Pharmacokinetics
topic Cannabis
Tetrahydrocannabinol
THC
Cannabidiol
CBD
Drug interactions
Medicines
Pharmacokinetics
description Cannabis is the most commonly used illicit substance worldwide. Recent years have seen an increase in cannabis consumption, and with new approvals and therapeutic indications, there are challenges in minimizing the risks and interactions between cannabis-based products, cannabis prescription drugs, other approved prescription drugs, and other substances of abuse. Thus, identifying the enzymes metabolizing cannabinoid drugs and their relationship with other prescription drugs is crucial for understanding the potential interactions and effects of their simultaneous use. This article offers a comprehensive review of cannabis and the pharmacokinetic interactions between cannabis products, cannabis prescription drugs, and other approved prescription drugs, as well as other substances of abuse. It also compiles existing evidence of these interactions and describes the clinical outcomes associated with the inhibition or induction of various enzymes.
publishDate 2025
dc.date.none.fl_str_mv 2
2025-01-01
2025
2025-01-01
dc.type.none.fl_str_mv Article de revisió
http://purl.org/coar/resource_type/c_dcae04bc
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/310447
https://dx.doi.org/urn:doi:10.3390/pharmaceutics17030319
url https://ddd.uab.cat/record/310447
https://dx.doi.org/urn:doi:10.3390/pharmaceutics17030319
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI20/00804
Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI24/00660
Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2021/SGR-00945
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.81155

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