Association Between Diagnostic Delay and Short-Term Outcomes in Patients with Radiographic Axial Spondyloarthritis: Results from the Regisponser-AS Registry

Objectives: To evaluate whether the diagnostic delay in patients with radiographic axial spondyloarthritis (r-axSpA) is associated with poorer short-term outcomes after two years of follow-up. Methods: This was an observational, longitudinal, and prospective study including patients with r-axSpA fro...

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Autores: Ladehesa-Pineda, ML, Ruiz-Vilchez, D, Barranco, AM, Puche-Larrubia, MA, Font-Ugalde, P, Granados, REM, Gratacós-Mastmijà, J, Juanola, X, Escudero-Contreras, A, Collantes-Estévez, E, López-Medina, C
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2025
País:España
Recursos:Institut d'Investigació i Innovació Parc Taulí (I3PT)
Repositório:r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
OAI Identifier:oai:i3pt.fundanetsuite.com:p6311
Acesso em linha:https://i3pt.portalinvestigacion.com/publicaciones/6311
https://www.scopus.com/inward/record.uri?eid=2-s2.0-105000881005&doi=10.3390%2Fjcm14061977&partnerID=40&md5=83e4b1def1e75e8060721d1bf5fe516b
Access Level:Acceso aberto
Palavra-chave:axial spondyloarthritis
structural damage
diagnostic delay
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spelling Association Between Diagnostic Delay and Short-Term Outcomes in Patients with Radiographic Axial Spondyloarthritis: Results from the Regisponser-AS RegistryLadehesa-Pineda, MLRuiz-Vilchez, DBarranco, AMPuche-Larrubia, MAFont-Ugalde, PGranados, REMGratacós-Mastmijà, JJuanola, XEscudero-Contreras, ACollantes-Estévez, ELópez-Medina, Caxial spondyloarthritisstructural damagediagnostic delayObjectives: To evaluate whether the diagnostic delay in patients with radiographic axial spondyloarthritis (r-axSpA) is associated with poorer short-term outcomes after two years of follow-up. Methods: This was an observational, longitudinal, and prospective study including patients with r-axSpA from the national multicentre Spanish REGISPONSER-AS registry. Patients were divided into two groups according to the mean diagnostic delay (<5 years, >= 5 years). Binary logistic regression models adjusted for disease duration were constructed and used to evaluate the association between diagnostic delay and disease outcomes at two years. The retention rate for first-line treatment with anti-TNF across the groups was evaluated using a log-rank test. Results: A total of 565 patents were included. The mean diagnostic delay was 5.6 +/- 6.2 years, with 325 patients experiencing a delay of <5 years and 240 patients experiencing a delay of >= 5 years. A diagnostic delay of >= 5 years was associated, after 2 years, with a higher prevalence of inflammatory bowel disease (IBD) (OR 2.01 (95%CI 1.06-3.83)), a lower prevalence of synovitis (OR 0.68 (95%CI 0.47-0.98)) and dactylitis (OR 0.24 (95%CI 0.11-0.55)), and worse disease activity after adjusting by disease duration. However, no impact was observed on quality of life, structural damage, or work disability, probably due to the short follow-up period. Finally, no differences between the groups were found with regard to the retention rate for first-line anti-TNF treatment. Conclusions: Diagnostic delay is associated with poorer short-term outcomes in terms of structural damage, dactylitis, and disability in patients with r-axSpA.MDPI2025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://i3pt.portalinvestigacion.com/publicaciones/6311https://www.scopus.com/inward/record.uri?eid=2-s2.0-105000881005&doi=10.3390%2Fjcm14061977&partnerID=40&md5=83e4b1def1e75e8060721d1bf5fe516bJournal of Clinical MedicineISSN: 20770383reponame:r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulíinstname:Institut d'Investigació i Innovació Parc Taulí (I3PT)Inglésinfo:eu-repo/semantics/openAccessoai:i3pt.fundanetsuite.com:p63112026-06-21T15:30:37Z
dc.title.none.fl_str_mv Association Between Diagnostic Delay and Short-Term Outcomes in Patients with Radiographic Axial Spondyloarthritis: Results from the Regisponser-AS Registry
title Association Between Diagnostic Delay and Short-Term Outcomes in Patients with Radiographic Axial Spondyloarthritis: Results from the Regisponser-AS Registry
spellingShingle Association Between Diagnostic Delay and Short-Term Outcomes in Patients with Radiographic Axial Spondyloarthritis: Results from the Regisponser-AS Registry
Ladehesa-Pineda, ML
axial spondyloarthritis
structural damage
diagnostic delay
title_short Association Between Diagnostic Delay and Short-Term Outcomes in Patients with Radiographic Axial Spondyloarthritis: Results from the Regisponser-AS Registry
title_full Association Between Diagnostic Delay and Short-Term Outcomes in Patients with Radiographic Axial Spondyloarthritis: Results from the Regisponser-AS Registry
title_fullStr Association Between Diagnostic Delay and Short-Term Outcomes in Patients with Radiographic Axial Spondyloarthritis: Results from the Regisponser-AS Registry
title_full_unstemmed Association Between Diagnostic Delay and Short-Term Outcomes in Patients with Radiographic Axial Spondyloarthritis: Results from the Regisponser-AS Registry
title_sort Association Between Diagnostic Delay and Short-Term Outcomes in Patients with Radiographic Axial Spondyloarthritis: Results from the Regisponser-AS Registry
dc.creator.none.fl_str_mv Ladehesa-Pineda, ML
Ruiz-Vilchez, D
Barranco, AM
Puche-Larrubia, MA
Font-Ugalde, P
Granados, REM
Gratacós-Mastmijà, J
Juanola, X
Escudero-Contreras, A
Collantes-Estévez, E
López-Medina, C
author Ladehesa-Pineda, ML
author_facet Ladehesa-Pineda, ML
Ruiz-Vilchez, D
Barranco, AM
Puche-Larrubia, MA
Font-Ugalde, P
Granados, REM
Gratacós-Mastmijà, J
Juanola, X
Escudero-Contreras, A
Collantes-Estévez, E
López-Medina, C
author_role author
author2 Ruiz-Vilchez, D
Barranco, AM
Puche-Larrubia, MA
Font-Ugalde, P
Granados, REM
Gratacós-Mastmijà, J
Juanola, X
Escudero-Contreras, A
Collantes-Estévez, E
López-Medina, C
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv axial spondyloarthritis
structural damage
diagnostic delay
topic axial spondyloarthritis
structural damage
diagnostic delay
description Objectives: To evaluate whether the diagnostic delay in patients with radiographic axial spondyloarthritis (r-axSpA) is associated with poorer short-term outcomes after two years of follow-up. Methods: This was an observational, longitudinal, and prospective study including patients with r-axSpA from the national multicentre Spanish REGISPONSER-AS registry. Patients were divided into two groups according to the mean diagnostic delay (<5 years, >= 5 years). Binary logistic regression models adjusted for disease duration were constructed and used to evaluate the association between diagnostic delay and disease outcomes at two years. The retention rate for first-line treatment with anti-TNF across the groups was evaluated using a log-rank test. Results: A total of 565 patents were included. The mean diagnostic delay was 5.6 +/- 6.2 years, with 325 patients experiencing a delay of <5 years and 240 patients experiencing a delay of >= 5 years. A diagnostic delay of >= 5 years was associated, after 2 years, with a higher prevalence of inflammatory bowel disease (IBD) (OR 2.01 (95%CI 1.06-3.83)), a lower prevalence of synovitis (OR 0.68 (95%CI 0.47-0.98)) and dactylitis (OR 0.24 (95%CI 0.11-0.55)), and worse disease activity after adjusting by disease duration. However, no impact was observed on quality of life, structural damage, or work disability, probably due to the short follow-up period. Finally, no differences between the groups were found with regard to the retention rate for first-line anti-TNF treatment. Conclusions: Diagnostic delay is associated with poorer short-term outcomes in terms of structural damage, dactylitis, and disability in patients with r-axSpA.
publishDate 2025
dc.date.none.fl_str_mv 2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://i3pt.portalinvestigacion.com/publicaciones/6311
https://www.scopus.com/inward/record.uri?eid=2-s2.0-105000881005&doi=10.3390%2Fjcm14061977&partnerID=40&md5=83e4b1def1e75e8060721d1bf5fe516b
url https://i3pt.portalinvestigacion.com/publicaciones/6311
https://www.scopus.com/inward/record.uri?eid=2-s2.0-105000881005&doi=10.3390%2Fjcm14061977&partnerID=40&md5=83e4b1def1e75e8060721d1bf5fe516b
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Journal of Clinical Medicine
ISSN: 20770383
reponame:r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
instname:Institut d'Investigació i Innovació Parc Taulí (I3PT)
instname_str Institut d'Investigació i Innovació Parc Taulí (I3PT)
reponame_str r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
collection r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
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