Absence of canonical active chromatin marks in developmentally regulated genes

The interplay of active and repressive histone modifications is assumed to have a key role in the regulation of gene expression. In contrast to this generally accepted view, we show that the transcription of genes temporally regulated during fly and worm development occurs in the absence of canonica...

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Autores: Pérez-Lluch, Sílvia, Blanco García, Enrique, Tilgner, Hagen, Curado, Joao, Ruiz Romero, Marina, Corominas, Montserrat (Corominas Guiu), Guigó Serra, Roderic
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2015
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/126592
Acceso en línea:https://hdl.handle.net/2445/126592
Access Level:acceso abierto
Palabra clave:Expressió gènica
Histones
Transcripció genètica
Gene expression
Genetic transcription
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spelling Absence of canonical active chromatin marks in developmentally regulated genesPérez-Lluch, SílviaBlanco García, EnriqueTilgner, HagenCurado, JoaoRuiz Romero, MarinaCorominas, Montserrat (Corominas Guiu)Guigó Serra, RodericExpressió gènicaHistonesTranscripció genèticaGene expressionHistonesGenetic transcriptionThe interplay of active and repressive histone modifications is assumed to have a key role in the regulation of gene expression. In contrast to this generally accepted view, we show that the transcription of genes temporally regulated during fly and worm development occurs in the absence of canonically active histone modifications. Conversely, strong chromatin marking is related to transcriptional and post-transcriptional stability, an association that we also observe in mammals. Our results support a model in which chromatin marking is associated with the stable production of RNA, whereas unmarked chromatin would permit rapid gene activation and deactivation during development. In the latter case, regulation by transcription factors would have a comparatively more important regulatory role than chromatin marks.Nature Publishing Group2018201820152018info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersion13 p.application/pdfhttps://hdl.handle.net/2445/126592Articles publicats en revistes (Genètica, Microbiologia i Estadística)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésVersió postprint del document publicat a: https://doi.org/10.1038/ng.3381Nature Genetics, 2015, vol. 47, num. 10, p. 1158-1167https://doi.org/10.1038/ng.3381info:eu-repo/grantAgreement/EC/FP7/294653info:eu-repo/grantAgreement/EC/FP7/277899(c) Pérez-Lluch, Sílvia et al., 2015info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1265922026-05-29T05:05:01Z
dc.title.none.fl_str_mv Absence of canonical active chromatin marks in developmentally regulated genes
title Absence of canonical active chromatin marks in developmentally regulated genes
spellingShingle Absence of canonical active chromatin marks in developmentally regulated genes
Pérez-Lluch, Sílvia
Expressió gènica
Histones
Transcripció genètica
Gene expression
Histones
Genetic transcription
title_short Absence of canonical active chromatin marks in developmentally regulated genes
title_full Absence of canonical active chromatin marks in developmentally regulated genes
title_fullStr Absence of canonical active chromatin marks in developmentally regulated genes
title_full_unstemmed Absence of canonical active chromatin marks in developmentally regulated genes
title_sort Absence of canonical active chromatin marks in developmentally regulated genes
dc.creator.none.fl_str_mv Pérez-Lluch, Sílvia
Blanco García, Enrique
Tilgner, Hagen
Curado, Joao
Ruiz Romero, Marina
Corominas, Montserrat (Corominas Guiu)
Guigó Serra, Roderic
author Pérez-Lluch, Sílvia
author_facet Pérez-Lluch, Sílvia
Blanco García, Enrique
Tilgner, Hagen
Curado, Joao
Ruiz Romero, Marina
Corominas, Montserrat (Corominas Guiu)
Guigó Serra, Roderic
author_role author
author2 Blanco García, Enrique
Tilgner, Hagen
Curado, Joao
Ruiz Romero, Marina
Corominas, Montserrat (Corominas Guiu)
Guigó Serra, Roderic
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Expressió gènica
Histones
Transcripció genètica
Gene expression
Histones
Genetic transcription
topic Expressió gènica
Histones
Transcripció genètica
Gene expression
Histones
Genetic transcription
description The interplay of active and repressive histone modifications is assumed to have a key role in the regulation of gene expression. In contrast to this generally accepted view, we show that the transcription of genes temporally regulated during fly and worm development occurs in the absence of canonically active histone modifications. Conversely, strong chromatin marking is related to transcriptional and post-transcriptional stability, an association that we also observe in mammals. Our results support a model in which chromatin marking is associated with the stable production of RNA, whereas unmarked chromatin would permit rapid gene activation and deactivation during development. In the latter case, regulation by transcription factors would have a comparatively more important regulatory role than chromatin marks.
publishDate 2015
dc.date.none.fl_str_mv 2015
2018
2018
2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/126592
url https://hdl.handle.net/2445/126592
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Versió postprint del document publicat a: https://doi.org/10.1038/ng.3381
Nature Genetics, 2015, vol. 47, num. 10, p. 1158-1167
https://doi.org/10.1038/ng.3381
info:eu-repo/grantAgreement/EC/FP7/294653
info:eu-repo/grantAgreement/EC/FP7/277899
dc.rights.none.fl_str_mv (c) Pérez-Lluch, Sílvia et al., 2015
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) Pérez-Lluch, Sílvia et al., 2015
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 13 p.
application/pdf
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv Articles publicats en revistes (Genètica, Microbiologia i Estadística)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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