Retrospective study of clinical and lesion characteristics of patients undergoing surgical treatment for Pulmonary Tuberculosis in Georgia

Our aim was to retrospectively compare clinical data and characteristics of removed lesions of the cohort of patients undergoing therapeutical surgery for their tuberculosis. Demographic and epidemiological details, clinical data, data on the surgery performed, macroscopic characteristics of the TB...

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Autores: Vashakidze, Sergo, Despuig, Albert, Gogishvili, Shota, Nikolaishvili, Keti, Shubladze, Natalia|||0000-0003-0580-9629, Avaliani, Zaza, Tukvadze, Nestan, Casals, Martí|||0000-0002-1775-8331, Caylà, Joan A..|||0000-0003-3891-111X, Cardona, Pere-Joan|||0000-0001-5623-7873, Vilaplana, Cristina|||0000-0002-2808-7270
Formato: artículo
Fecha de publicación:2016
País:España
Recursos:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:187830
Acesso em linha:https://ddd.uab.cat/record/187830
https://dx.doi.org/urn:doi:10.1016/j.ijid.2016.12.009
Access Level:acceso abierto
Palavra-chave:Tuberculosis
Surgery
Gender
DS-TB
MDR/XDR-TB
Necrosis
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spelling Retrospective study of clinical and lesion characteristics of patients undergoing surgical treatment for Pulmonary Tuberculosis in GeorgiaVashakidze, SergoDespuig, AlbertGogishvili, ShotaNikolaishvili, KetiShubladze, Natalia|||0000-0003-0580-9629Avaliani, ZazaTukvadze, NestanCasals, Martí|||0000-0002-1775-8331Caylà, Joan A..|||0000-0003-3891-111XCardona, Pere-Joan|||0000-0001-5623-7873Vilaplana, Cristina|||0000-0002-2808-7270TuberculosisSurgeryGenderDS-TBMDR/XDR-TBNecrosisOur aim was to retrospectively compare clinical data and characteristics of removed lesions of the cohort of patients undergoing therapeutical surgery for their tuberculosis. Demographic and epidemiological details, clinical data, data on the surgery performed, macroscopic characteristics of the TB lesions removed, and outcome were recorded retrospectively from the 137 patients who underwent therapeutical surgery for their TB in Tbilisi, Georgia during 2014 and 2015. Men represented 70% of the included patients, presented more comorbidities and underwent operation earlier in terms of days between diagnostic and surgery. Women underwent operation at younger ages, and in MDR/XDR-TB cases, showed higher percentages of sputum conversion at >2 months and of fresh necrosis in the surgical specimens, suggesting a worse evolution. Half of cases were MDR/XDR-TB cases. In spite of being considered microbiologically cured according to WHO, a non despricable percentage of cases showed viable bacilli in the surgical specimen. Even if no causality could be statistically demonstrated, differences could be encountered according to gender and drug susceptibility of the responsible strains. According to our results, host factors such as gender, type of necrosis found in the lesions, size of lesions and presence of viable bacilli in the surgical specimen, should be included in future studies on therapeutical surgery of TB. As most of studies are done in MDR/XDR-TB, more data on DS-TB operated cases are needed. Our results also highlight that, in spite of achieving the microbiologically cured status, sterilization might not occur, and thus new biomarkers and new methods to evaluate the healing process of TB patients are urgently needed and radiological assays should be taken into account.Universitat Autònoma de Barcelona 22016-01-0120162016-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/187830https://dx.doi.org/urn:doi:10.1016/j.ijid.2016.12.009reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengInstituto de Salud Carlos III https://doi.org/10.13039/501100004587 CP13-00174open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:1878302026-06-06T12:50:31Z
dc.title.none.fl_str_mv Retrospective study of clinical and lesion characteristics of patients undergoing surgical treatment for Pulmonary Tuberculosis in Georgia
title Retrospective study of clinical and lesion characteristics of patients undergoing surgical treatment for Pulmonary Tuberculosis in Georgia
spellingShingle Retrospective study of clinical and lesion characteristics of patients undergoing surgical treatment for Pulmonary Tuberculosis in Georgia
Vashakidze, Sergo
Tuberculosis
Surgery
Gender
DS-TB
MDR/XDR-TB
Necrosis
title_short Retrospective study of clinical and lesion characteristics of patients undergoing surgical treatment for Pulmonary Tuberculosis in Georgia
title_full Retrospective study of clinical and lesion characteristics of patients undergoing surgical treatment for Pulmonary Tuberculosis in Georgia
title_fullStr Retrospective study of clinical and lesion characteristics of patients undergoing surgical treatment for Pulmonary Tuberculosis in Georgia
title_full_unstemmed Retrospective study of clinical and lesion characteristics of patients undergoing surgical treatment for Pulmonary Tuberculosis in Georgia
title_sort Retrospective study of clinical and lesion characteristics of patients undergoing surgical treatment for Pulmonary Tuberculosis in Georgia
dc.creator.none.fl_str_mv Vashakidze, Sergo
Despuig, Albert
Gogishvili, Shota
Nikolaishvili, Keti
Shubladze, Natalia|||0000-0003-0580-9629
Avaliani, Zaza
Tukvadze, Nestan
Casals, Martí|||0000-0002-1775-8331
Caylà, Joan A..|||0000-0003-3891-111X
Cardona, Pere-Joan|||0000-0001-5623-7873
Vilaplana, Cristina|||0000-0002-2808-7270
author Vashakidze, Sergo
author_facet Vashakidze, Sergo
Despuig, Albert
Gogishvili, Shota
Nikolaishvili, Keti
Shubladze, Natalia|||0000-0003-0580-9629
Avaliani, Zaza
Tukvadze, Nestan
Casals, Martí|||0000-0002-1775-8331
Caylà, Joan A..|||0000-0003-3891-111X
Cardona, Pere-Joan|||0000-0001-5623-7873
Vilaplana, Cristina|||0000-0002-2808-7270
author_role author
author2 Despuig, Albert
Gogishvili, Shota
Nikolaishvili, Keti
Shubladze, Natalia|||0000-0003-0580-9629
Avaliani, Zaza
Tukvadze, Nestan
Casals, Martí|||0000-0002-1775-8331
Caylà, Joan A..|||0000-0003-3891-111X
Cardona, Pere-Joan|||0000-0001-5623-7873
Vilaplana, Cristina|||0000-0002-2808-7270
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universitat Autònoma de Barcelona
dc.subject.none.fl_str_mv Tuberculosis
Surgery
Gender
DS-TB
MDR/XDR-TB
Necrosis
topic Tuberculosis
Surgery
Gender
DS-TB
MDR/XDR-TB
Necrosis
description Our aim was to retrospectively compare clinical data and characteristics of removed lesions of the cohort of patients undergoing therapeutical surgery for their tuberculosis. Demographic and epidemiological details, clinical data, data on the surgery performed, macroscopic characteristics of the TB lesions removed, and outcome were recorded retrospectively from the 137 patients who underwent therapeutical surgery for their TB in Tbilisi, Georgia during 2014 and 2015. Men represented 70% of the included patients, presented more comorbidities and underwent operation earlier in terms of days between diagnostic and surgery. Women underwent operation at younger ages, and in MDR/XDR-TB cases, showed higher percentages of sputum conversion at >2 months and of fresh necrosis in the surgical specimens, suggesting a worse evolution. Half of cases were MDR/XDR-TB cases. In spite of being considered microbiologically cured according to WHO, a non despricable percentage of cases showed viable bacilli in the surgical specimen. Even if no causality could be statistically demonstrated, differences could be encountered according to gender and drug susceptibility of the responsible strains. According to our results, host factors such as gender, type of necrosis found in the lesions, size of lesions and presence of viable bacilli in the surgical specimen, should be included in future studies on therapeutical surgery of TB. As most of studies are done in MDR/XDR-TB, more data on DS-TB operated cases are needed. Our results also highlight that, in spite of achieving the microbiologically cured status, sterilization might not occur, and thus new biomarkers and new methods to evaluate the healing process of TB patients are urgently needed and radiological assays should be taken into account.
publishDate 2016
dc.date.none.fl_str_mv 2
2016-01-01
2016
2016-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/187830
https://dx.doi.org/urn:doi:10.1016/j.ijid.2016.12.009
url https://ddd.uab.cat/record/187830
https://dx.doi.org/urn:doi:10.1016/j.ijid.2016.12.009
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 CP13-00174
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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