Pregnancy induces longitudinal changes in urinary C-peptide creatinine ratio in women with type 1 diabetes

AimsChanges in maternal serum C-peptide have been described during pregnancy in women with Type 1 diabetes. We aimed to determine whether in these women, C-peptide, as measured by the urinary C-peptide creatinine ratio (UCPCR), display changes during the course of pregnancy and in the postpartum per...

ver descrição completa

Detalhes bibliográficos
Autores: Mendoza L.C., Tashkova M., Corcoy R., Dornhorst A.
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Recursos:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
Repositorio:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
OAI Identifier:oai:iibsantpau.fundanetsuite.com:p16385
Acesso em linha:https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=16385
http://ddd.uab.cat/record/301698
Access Level:acceso abierto
Palavra-chave:C-peptide
pregnancy
type 1 diabetes
urinary C-peptide creatinine ratio
id ES_dcff8bf03d6e921fbd730b4c6abf111e
oai_identifier_str oai:iibsantpau.fundanetsuite.com:p16385
network_acronym_str ES
network_name_str España
repository_id_str
spelling Pregnancy induces longitudinal changes in urinary C-peptide creatinine ratio in women with type 1 diabetesMendoza L.C.Tashkova M.Corcoy R.Dornhorst A.C-peptidepregnancytype 1 diabetesurinary C-peptide creatinine ratioAimsChanges in maternal serum C-peptide have been described during pregnancy in women with Type 1 diabetes. We aimed to determine whether in these women, C-peptide, as measured by the urinary C-peptide creatinine ratio (UCPCR), display changes during the course of pregnancy and in the postpartum period. MethodsIn this longitudinal study including 26 women, UCPCR was measured in the first, second, and third trimester of pregnancy, and postpartum, using a high sensitivity two-step chemiluminescent microparticle immunoassay. ResultsUCPCR was detectable in 7/26 (26.9%) participants in the first trimester, 10/26 (38.4%) in the second trimester, and 18/26 (69.2%) in the third trimester. Changes in UCPCR concentrations were observed throughout pregnancy, significantly increasing from first to third trimester. UCPCR concentration in the three trimesters was associated with a shorter duration of diabetes and in the third trimester also with first trimester UCPCR. ConclusionUCPCR detects longitudinal changes during pregnancy in women with type 1 diabetes mellitus, more marked in those with shorter diabetes duration.WILEY2024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=16385http://ddd.uab.cat/record/301698DIABETIC MEDICINEISSN: 07423071ISSNe: 14645491reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pauinstname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)Inglésinfo:eu-repo/semantics/openAccessoai:iibsantpau.fundanetsuite.com:p163852026-06-14T12:41:47Z
dc.title.none.fl_str_mv Pregnancy induces longitudinal changes in urinary C-peptide creatinine ratio in women with type 1 diabetes
title Pregnancy induces longitudinal changes in urinary C-peptide creatinine ratio in women with type 1 diabetes
spellingShingle Pregnancy induces longitudinal changes in urinary C-peptide creatinine ratio in women with type 1 diabetes
Mendoza L.C.
C-peptide
pregnancy
type 1 diabetes
urinary C-peptide creatinine ratio
title_short Pregnancy induces longitudinal changes in urinary C-peptide creatinine ratio in women with type 1 diabetes
title_full Pregnancy induces longitudinal changes in urinary C-peptide creatinine ratio in women with type 1 diabetes
title_fullStr Pregnancy induces longitudinal changes in urinary C-peptide creatinine ratio in women with type 1 diabetes
title_full_unstemmed Pregnancy induces longitudinal changes in urinary C-peptide creatinine ratio in women with type 1 diabetes
title_sort Pregnancy induces longitudinal changes in urinary C-peptide creatinine ratio in women with type 1 diabetes
dc.creator.none.fl_str_mv Mendoza L.C.
Tashkova M.
Corcoy R.
Dornhorst A.
author Mendoza L.C.
author_facet Mendoza L.C.
Tashkova M.
Corcoy R.
Dornhorst A.
author_role author
author2 Tashkova M.
Corcoy R.
Dornhorst A.
author2_role author
author
author
dc.subject.none.fl_str_mv C-peptide
pregnancy
type 1 diabetes
urinary C-peptide creatinine ratio
topic C-peptide
pregnancy
type 1 diabetes
urinary C-peptide creatinine ratio
description AimsChanges in maternal serum C-peptide have been described during pregnancy in women with Type 1 diabetes. We aimed to determine whether in these women, C-peptide, as measured by the urinary C-peptide creatinine ratio (UCPCR), display changes during the course of pregnancy and in the postpartum period. MethodsIn this longitudinal study including 26 women, UCPCR was measured in the first, second, and third trimester of pregnancy, and postpartum, using a high sensitivity two-step chemiluminescent microparticle immunoassay. ResultsUCPCR was detectable in 7/26 (26.9%) participants in the first trimester, 10/26 (38.4%) in the second trimester, and 18/26 (69.2%) in the third trimester. Changes in UCPCR concentrations were observed throughout pregnancy, significantly increasing from first to third trimester. UCPCR concentration in the three trimesters was associated with a shorter duration of diabetes and in the third trimester also with first trimester UCPCR. ConclusionUCPCR detects longitudinal changes during pregnancy in women with type 1 diabetes mellitus, more marked in those with shorter diabetes duration.
publishDate 2024
dc.date.none.fl_str_mv 2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=16385
http://ddd.uab.cat/record/301698
url https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=16385
http://ddd.uab.cat/record/301698
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv WILEY
publisher.none.fl_str_mv WILEY
dc.source.none.fl_str_mv DIABETIC MEDICINE
ISSN: 07423071
ISSNe: 14645491
reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
instname_str Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
reponame_str r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
collection r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869421819963899904
score 15,812455

Registos relacionados