The central biobank and virtual biobank of BIOMARKAPD

Biobanks are important resources for biomarker discovery and assay development. Biomarkers for Alzheimer's and Parkinson's disease (BIOMARKAPD) is a European multicenter study, funded by the EU Joint Programme-Neurodegenerative Disease Research, which aims to improve the clinical use of bo...

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Autores: Reijs, Babette L. R., Teunissen, Charlotte E.|||0000-0002-4061-0837, Goncharenko, Nikolai|||0000-0002-9873-1885, Betsou, Fay|||0000-0002-0558-4653, Blennow, Kaj|||0000-0002-1890-4193, Baldeiras, Inês|||0000-0002-8106-7308, Brosseron, Frederic, Cavedo, Enrica|||0000-0003-2306-0164, Fladby, Tormod|||0000-0002-9984-9797, Froelich, Lutz|||0000-0003-1494-0813, Gabryelewicz, Tomasz, Gurvit, Hakan|||0000-0003-2908-8475, Kapaki, Elisabeth N., Koson, Peter, Kulic, Luka, Lehmann, Sylvain|||0000-0001-6117-562X, Lewczuk, Piotr|||0000-0002-8101-6535, Lleó, Alberto|||0000-0002-2568-5478, Maetzler, Walter|||0000-0002-5945-4694, de Mendonça, Alexandre|||0000-0002-0488-1453, Miller, Anne-Marie, Molinuevo, José Luis|||0000-0003-0485-6001, Mollenhauer, Brit|||0000-0001-8437-3645, Parnetti, Lucilla|||0000-0001-5722-3967, Rot, Uroš, Schneider, Anja|||0000-0001-9540-8700, Simonsen, Anja Hviid|||0000-0002-5461-162X, Tagliavini, Fabrizio|||0000-0003-1039-7315, Tsolaki, Magda|||0000-0002-2072-8010, Verbeek, Marcel|||0000-0003-4635-7876, Verhey, Frans, Zboch, Marzena, Winblad, Bengt|||0000-0002-0011-1179, Scheltens, Philip|||0000-0002-1046-6408, Zetterberg, Henrik|||0000-0003-3930-4354, Visser, Pieter Jelle|||0000-0001-8008-9727
Tipo de documento: artigo
Data de publicação:2015
País:España
Recursos:Universitat Autònoma de Barcelona
Repositório:Dipòsit Digital de Documents de la UAB
Idioma:inglês
OAI Identifier:oai:ddd.uab.cat:300239
Acesso em linha:https://ddd.uab.cat/record/300239
https://dx.doi.org/urn:doi:10.3389/fneur.2015.00216
Access Level:Acceso aberto
Palavra-chave:Alzheimer's disease
Biobank
Body fluids
Cerebrospinal fluid
Dementia
Neurodegenerative disorders
Parkinson's disease
Descrição
Resumo:Biobanks are important resources for biomarker discovery and assay development. Biomarkers for Alzheimer's and Parkinson's disease (BIOMARKAPD) is a European multicenter study, funded by the EU Joint Programme-Neurodegenerative Disease Research, which aims to improve the clinical use of body fluid markers for the diagnosis and prognosis of Alzheimer's disease (AD) and Parkinson's disease (PD). The objective was to standardize the assessment of existing assays and to validate novel fluid biomarkers for AD and PD. To support the validation of novel biomarkers and assays, a central and a virtual biobank for body fluids and associated data from subjects with neurodegenerative diseases have been established. In the central biobank, cerebrospinal fluid (CSF) and blood samples were collected according to the BIOMARKAPD standardized pre-analytical procedures and stored at Integrated BioBank of Luxembourg. The virtual biobank provides an overview of available CSF, plasma, serum, and DNA samples at each site. Currently, at the central biobank of BIOMARKAPD samples are available from over 400 subjects with normal cognition, mild cognitive impairment (MCI), AD, frontotemporal dementia (FTD), vascular dementia, multiple system atrophy, progressive supranuclear palsy, PD, PD with dementia, and dementia with Lewy bodies. The virtual biobank contains information on over 8,600 subjects with varying diagnoses from 21 local biobanks. A website has been launched to enable sample requests from the central biobank and virtual biobank.

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