Biocompatibility Study of a Commercial Printed Circuit Board for Biomedical Applications: Lab-on-PCB for Organotypic Retina Cultures

Printed circuit board (PCB) technology is well known, reliable, and low-cost, and its application to biomedicine, which implies the integration of microfluidics and electronics, has led to Lab-on-PCB. However, the biocompatibility of the involved materials has to be examined if they are in contact w...

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Authors: Urbano Gámez, Jesús David, Valdés Sánchez, Lourdes, Aracil Fernández, Carmen, De la Cerda, Berta, Perdigones Sánchez, Francisco, Plaza Reyes, Álvaro, Díaz Corrales, Francisco Javier, Relimpio López, Isabel, Quero Reboul, José Manuel
Format: article
Status:Published version
Publication Date:2021
Country:España
Institution:Universidad de Sevilla (US)
Repository:idUS. Depósito de Investigación de la Universidad de Sevilla
OAI Identifier:oai:idus.us.es:11441/129808
Online Access:https://hdl.handle.net/11441/129808
https://doi.org/10.3390/mi12121469
Access Level:Open access
Keyword:Lab-on-PCB
Printed circuit board
Organotypic culture
Biomedical applications
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spelling Biocompatibility Study of a Commercial Printed Circuit Board for Biomedical Applications: Lab-on-PCB for Organotypic Retina CulturesUrbano Gámez, Jesús DavidValdés Sánchez, LourdesAracil Fernández, CarmenDe la Cerda, BertaPerdigones Sánchez, FranciscoPlaza Reyes, ÁlvaroDíaz Corrales, Francisco JavierRelimpio López, IsabelQuero Reboul, José ManuelLab-on-PCBPrinted circuit boardOrganotypic cultureBiomedical applicationsPrinted circuit board (PCB) technology is well known, reliable, and low-cost, and its application to biomedicine, which implies the integration of microfluidics and electronics, has led to Lab-on-PCB. However, the biocompatibility of the involved materials has to be examined if they are in contact with biological elements. In this paper, the solder mask (PSR-2000 CD02G/CA-25 CD01, Taiyo Ink (Suzhou) Co., Ltd., Suzhou, China) of a commercial PCB has been studied for retinal cultures. For this purpose, retinal explants have been cultured over this substrate, both on open and closed systems, with successful results. Cell viability data shows that the solder mask has no cytotoxic effect on the culture allowing the application of PCB as the substrate of customized microelectrode arrays (MEAs). Finally, a comparative study of the biocompatibility of the 3D printer Uniz zSG amber resin has also been carried out.Unión Europea US-1265983Consejería de Economía, Conocimiento, Empresas y Universidad de la Junta de Andalucía US-1265983MDPIIngeniería ElectrónicaTIC109: Tecnología ElectrónicaEuropean Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER)Junta de Andalucía2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/11441/129808https://doi.org/10.3390/mi12121469reponame:idUS. Depósito de Investigación de la Universidad de Sevillainstname:Universidad de Sevilla (US)InglésMicromachines, 12 (12). Article number 1469.US-1265983https://doi.org/10.3390/mi12121469info:eu-repo/semantics/openAccessoai:idus.us.es:11441/1298082026-06-17T12:51:07Z
dc.title.none.fl_str_mv Biocompatibility Study of a Commercial Printed Circuit Board for Biomedical Applications: Lab-on-PCB for Organotypic Retina Cultures
title Biocompatibility Study of a Commercial Printed Circuit Board for Biomedical Applications: Lab-on-PCB for Organotypic Retina Cultures
spellingShingle Biocompatibility Study of a Commercial Printed Circuit Board for Biomedical Applications: Lab-on-PCB for Organotypic Retina Cultures
Urbano Gámez, Jesús David
Lab-on-PCB
Printed circuit board
Organotypic culture
Biomedical applications
title_short Biocompatibility Study of a Commercial Printed Circuit Board for Biomedical Applications: Lab-on-PCB for Organotypic Retina Cultures
title_full Biocompatibility Study of a Commercial Printed Circuit Board for Biomedical Applications: Lab-on-PCB for Organotypic Retina Cultures
title_fullStr Biocompatibility Study of a Commercial Printed Circuit Board for Biomedical Applications: Lab-on-PCB for Organotypic Retina Cultures
title_full_unstemmed Biocompatibility Study of a Commercial Printed Circuit Board for Biomedical Applications: Lab-on-PCB for Organotypic Retina Cultures
title_sort Biocompatibility Study of a Commercial Printed Circuit Board for Biomedical Applications: Lab-on-PCB for Organotypic Retina Cultures
dc.creator.none.fl_str_mv Urbano Gámez, Jesús David
Valdés Sánchez, Lourdes
Aracil Fernández, Carmen
De la Cerda, Berta
Perdigones Sánchez, Francisco
Plaza Reyes, Álvaro
Díaz Corrales, Francisco Javier
Relimpio López, Isabel
Quero Reboul, José Manuel
author Urbano Gámez, Jesús David
author_facet Urbano Gámez, Jesús David
Valdés Sánchez, Lourdes
Aracil Fernández, Carmen
De la Cerda, Berta
Perdigones Sánchez, Francisco
Plaza Reyes, Álvaro
Díaz Corrales, Francisco Javier
Relimpio López, Isabel
Quero Reboul, José Manuel
author_role author
author2 Valdés Sánchez, Lourdes
Aracil Fernández, Carmen
De la Cerda, Berta
Perdigones Sánchez, Francisco
Plaza Reyes, Álvaro
Díaz Corrales, Francisco Javier
Relimpio López, Isabel
Quero Reboul, José Manuel
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Ingeniería Electrónica
TIC109: Tecnología Electrónica
European Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER)
Junta de Andalucía
dc.subject.none.fl_str_mv Lab-on-PCB
Printed circuit board
Organotypic culture
Biomedical applications
topic Lab-on-PCB
Printed circuit board
Organotypic culture
Biomedical applications
description Printed circuit board (PCB) technology is well known, reliable, and low-cost, and its application to biomedicine, which implies the integration of microfluidics and electronics, has led to Lab-on-PCB. However, the biocompatibility of the involved materials has to be examined if they are in contact with biological elements. In this paper, the solder mask (PSR-2000 CD02G/CA-25 CD01, Taiyo Ink (Suzhou) Co., Ltd., Suzhou, China) of a commercial PCB has been studied for retinal cultures. For this purpose, retinal explants have been cultured over this substrate, both on open and closed systems, with successful results. Cell viability data shows that the solder mask has no cytotoxic effect on the culture allowing the application of PCB as the substrate of customized microelectrode arrays (MEAs). Finally, a comparative study of the biocompatibility of the 3D printer Uniz zSG amber resin has also been carried out.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11441/129808
https://doi.org/10.3390/mi12121469
url https://hdl.handle.net/11441/129808
https://doi.org/10.3390/mi12121469
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Micromachines, 12 (12). Article number 1469.
US-1265983
https://doi.org/10.3390/mi12121469
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:idUS. Depósito de Investigación de la Universidad de Sevilla
instname:Universidad de Sevilla (US)
instname_str Universidad de Sevilla (US)
reponame_str idUS. Depósito de Investigación de la Universidad de Sevilla
collection idUS. Depósito de Investigación de la Universidad de Sevilla
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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