Microvascular Obstruction in ST-Segment Elevation Myocardial Infarction

After a myocardial infarction (MI), despite the resolution of the coronary occlusion, the deterioration of myocardial perfusion persists in a considerable number of patients. This phenomenon is known as microvascular obstruction (MVO). Initially, the focus was placed on re-establishing blood flow in...

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Autores: Rios-Navarro, Cesar|||0000-0002-6405-6279, Marcos-Garces, Victor|||0000-0001-5565-5547, Bayés-Genís, Antoni|||0000-0002-3044-197X, Núñez, Julio|||0000-0003-1672-7119, Bodi, Vicente|||0000-0001-6425-5828
Tipo de recurso: artículo
Fecha de publicación:2019
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:253367
Acceso en línea:https://ddd.uab.cat/record/253367
https://dx.doi.org/urn:doi:10.3390/jcm8111805
Access Level:acceso abierto
Palabra clave:Myocardial infarction
Microvascular obstruction
Reperfusion injury
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spelling Microvascular Obstruction in ST-Segment Elevation Myocardial InfarctionLooking Back to Move Forward. Focus on CMRRios-Navarro, Cesar|||0000-0002-6405-6279Marcos-Garces, Victor|||0000-0001-5565-5547Bayés-Genís, Antoni|||0000-0002-3044-197XNúñez, Julio|||0000-0003-1672-7119Bodi, Vicente|||0000-0001-6425-5828Myocardial infarctionMicrovascular obstructionReperfusion injuryAfter a myocardial infarction (MI), despite the resolution of the coronary occlusion, the deterioration of myocardial perfusion persists in a considerable number of patients. This phenomenon is known as microvascular obstruction (MVO). Initially, the focus was placed on re-establishing blood flow in the epicardial artery. Then, the observation that MVO has profound negative structural and prognostic repercussions revived interest in microcirculation. In the near future, the availability of co-adjuvant therapies (beyond timely coronary reperfusion) aimed at preventing, minimizing, and repairing MVOs and finding convincing answers to questions regarding what, when, how, and where to administer these therapies will be of utmost importance. The objective of this work is to review the state-of-the-art concepts on pathophysiology, diagnostic methods, and structural and clinical implications of MVOs in patients with ST-segment elevation MIs. Based on this knowledge we discuss previously-tested and future opportunities for the prevention and repair of MVO. 22019-01-0120192019-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/253367https://dx.doi.org/urn:doi:10.3390/jcm8111805reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengMinisterio de Economía y Competitividad https://doi.org/10.13039/501100003329 PIE15/00013Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI17/01836Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 CIBERCV16/11/00486open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2533672026-06-06T12:50:31Z
dc.title.none.fl_str_mv Microvascular Obstruction in ST-Segment Elevation Myocardial Infarction
Looking Back to Move Forward. Focus on CMR
title Microvascular Obstruction in ST-Segment Elevation Myocardial Infarction
spellingShingle Microvascular Obstruction in ST-Segment Elevation Myocardial Infarction
Rios-Navarro, Cesar|||0000-0002-6405-6279
Myocardial infarction
Microvascular obstruction
Reperfusion injury
title_short Microvascular Obstruction in ST-Segment Elevation Myocardial Infarction
title_full Microvascular Obstruction in ST-Segment Elevation Myocardial Infarction
title_fullStr Microvascular Obstruction in ST-Segment Elevation Myocardial Infarction
title_full_unstemmed Microvascular Obstruction in ST-Segment Elevation Myocardial Infarction
title_sort Microvascular Obstruction in ST-Segment Elevation Myocardial Infarction
dc.creator.none.fl_str_mv Rios-Navarro, Cesar|||0000-0002-6405-6279
Marcos-Garces, Victor|||0000-0001-5565-5547
Bayés-Genís, Antoni|||0000-0002-3044-197X
Núñez, Julio|||0000-0003-1672-7119
Bodi, Vicente|||0000-0001-6425-5828
author Rios-Navarro, Cesar|||0000-0002-6405-6279
author_facet Rios-Navarro, Cesar|||0000-0002-6405-6279
Marcos-Garces, Victor|||0000-0001-5565-5547
Bayés-Genís, Antoni|||0000-0002-3044-197X
Núñez, Julio|||0000-0003-1672-7119
Bodi, Vicente|||0000-0001-6425-5828
author_role author
author2 Marcos-Garces, Victor|||0000-0001-5565-5547
Bayés-Genís, Antoni|||0000-0002-3044-197X
Núñez, Julio|||0000-0003-1672-7119
Bodi, Vicente|||0000-0001-6425-5828
author2_role author
author
author
author
dc.subject.none.fl_str_mv Myocardial infarction
Microvascular obstruction
Reperfusion injury
topic Myocardial infarction
Microvascular obstruction
Reperfusion injury
description After a myocardial infarction (MI), despite the resolution of the coronary occlusion, the deterioration of myocardial perfusion persists in a considerable number of patients. This phenomenon is known as microvascular obstruction (MVO). Initially, the focus was placed on re-establishing blood flow in the epicardial artery. Then, the observation that MVO has profound negative structural and prognostic repercussions revived interest in microcirculation. In the near future, the availability of co-adjuvant therapies (beyond timely coronary reperfusion) aimed at preventing, minimizing, and repairing MVOs and finding convincing answers to questions regarding what, when, how, and where to administer these therapies will be of utmost importance. The objective of this work is to review the state-of-the-art concepts on pathophysiology, diagnostic methods, and structural and clinical implications of MVOs in patients with ST-segment elevation MIs. Based on this knowledge we discuss previously-tested and future opportunities for the prevention and repair of MVO.
publishDate 2019
dc.date.none.fl_str_mv 2
2019-01-01
2019
2019-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
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dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/253367
https://dx.doi.org/urn:doi:10.3390/jcm8111805
url https://ddd.uab.cat/record/253367
https://dx.doi.org/urn:doi:10.3390/jcm8111805
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 PIE15/00013
Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI17/01836
Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 CIBERCV16/11/00486
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
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eu_rights_str_mv openAccess
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dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
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