Distinct modes of action of CD40L and adaptive cytokines IL-2, IL-4/13, IL-10 and IL-21 on rainbow trout IgM<sup>+</sup> B cells

11 Pág.

Detalles Bibliográficos
Autores: Abós, Beatriz, Wang, Tiehui, Secombes, Christopher J., Tafalla, Carolina
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/338474
Acceso en línea:http://hdl.handle.net/10261/338474
https://api.elsevier.com/content/abstract/scopus_id/85085513333
Access Level:acceso abierto
Palabra clave:B cells
CD40L
IL-10
IL-21
IL-2B
IL-4/13
id ES_dced3d6804a47f4ef12e975e44b0a718
oai_identifier_str oai:digital.csic.es:10261/338474
network_acronym_str ES
network_name_str España
repository_id_str
spelling Distinct modes of action of CD40L and adaptive cytokines IL-2, IL-4/13, IL-10 and IL-21 on rainbow trout IgM<sup>+</sup> B cellsAbós, BeatrizWang, TiehuiSecombes, Christopher J.Tafalla, CarolinaB cellsCD40LIL-10IL-21IL-2BIL-4/1311 Pág.In mammals, conventional B (B2) cells are activated within lymphoid follicles through a close relationship with T follicular helper (Tfh) cells. The interaction between CD40 expressed on B cells and its ligand (CD40L) expressed on Tfh cells is a key signal that regulates the formation of germinal centers (GCs), B cell survival, proliferation and differentiation to plasma cells (PCs) or memory cells. Additionally, certain soluble cytokines produced by T cells also strongly condition the outcome of this interaction. Despite the many differences found between fish B cells and mammalian B2 cells, and the lack of conventional GCs, rainbow trout IgM+ B cells have been shown to be stimulated by CD40L, however, whether cytokines commonly produced by T cells can further modulate this response has never been addressed to date. Thus, in this study, we determined the effects of recombinant rainbow trout adaptive cytokines interleukin 2B (IL-2B), IL-4/13A, IL-4/13B, IL-10 and IL-21 (cytokines known to activate B cells in mammals) on splenic IgM+ B cells alone or in combination with CD40L. We studied how these cytokines and CD40L cooperated to promote IgM+ B cell survival, proliferation and IgM secretion. The results obtained provide valuable information for the first time in teleost fish on how different T cell signals cooperate to activate B cells in the absence of GCs.This work was supported by the European Research Council (ERC Consolidator Grant 725061) and by the Spanish Ministry of Science, Innovation and Universities (project AGL2017-85494-C2-1-R).Peer reviewedElsevierEuropean CommissionMinisterio de Ciencia, Innovación y Universidades (España)Agencia Estatal de Investigación (España)Abós, Beatriz (0000-0002-3402-7397)Wang, Tiehui [0000-0002-1148-8959]Secombes, Christopher J. [0000-0001-8781-176X]Tafalla, Carolina [0000-0002-0860-2976]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202320232020info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/338474https://api.elsevier.com/content/abstract/scopus_id/85085513333reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/EC//725061info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2017-85494-C2-1-RCentro de Investigación en Sanidad Animal (CISA)https://doi.org/10.1016/j.dci.2020.103752Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3384742026-05-22T06:33:51Z
dc.title.none.fl_str_mv Distinct modes of action of CD40L and adaptive cytokines IL-2, IL-4/13, IL-10 and IL-21 on rainbow trout IgM<sup>+</sup> B cells
title Distinct modes of action of CD40L and adaptive cytokines IL-2, IL-4/13, IL-10 and IL-21 on rainbow trout IgM<sup>+</sup> B cells
spellingShingle Distinct modes of action of CD40L and adaptive cytokines IL-2, IL-4/13, IL-10 and IL-21 on rainbow trout IgM<sup>+</sup> B cells
Abós, Beatriz
B cells
CD40L
IL-10
IL-21
IL-2B
IL-4/13
title_short Distinct modes of action of CD40L and adaptive cytokines IL-2, IL-4/13, IL-10 and IL-21 on rainbow trout IgM<sup>+</sup> B cells
title_full Distinct modes of action of CD40L and adaptive cytokines IL-2, IL-4/13, IL-10 and IL-21 on rainbow trout IgM<sup>+</sup> B cells
title_fullStr Distinct modes of action of CD40L and adaptive cytokines IL-2, IL-4/13, IL-10 and IL-21 on rainbow trout IgM<sup>+</sup> B cells
title_full_unstemmed Distinct modes of action of CD40L and adaptive cytokines IL-2, IL-4/13, IL-10 and IL-21 on rainbow trout IgM<sup>+</sup> B cells
title_sort Distinct modes of action of CD40L and adaptive cytokines IL-2, IL-4/13, IL-10 and IL-21 on rainbow trout IgM<sup>+</sup> B cells
dc.creator.none.fl_str_mv Abós, Beatriz
Wang, Tiehui
Secombes, Christopher J.
Tafalla, Carolina
author Abós, Beatriz
author_facet Abós, Beatriz
Wang, Tiehui
Secombes, Christopher J.
Tafalla, Carolina
author_role author
author2 Wang, Tiehui
Secombes, Christopher J.
Tafalla, Carolina
author2_role author
author
author
dc.contributor.none.fl_str_mv European Commission
Ministerio de Ciencia, Innovación y Universidades (España)
Agencia Estatal de Investigación (España)
Abós, Beatriz (0000-0002-3402-7397)
Wang, Tiehui [0000-0002-1148-8959]
Secombes, Christopher J. [0000-0001-8781-176X]
Tafalla, Carolina [0000-0002-0860-2976]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv B cells
CD40L
IL-10
IL-21
IL-2B
IL-4/13
topic B cells
CD40L
IL-10
IL-21
IL-2B
IL-4/13
description 11 Pág.
publishDate 2020
dc.date.none.fl_str_mv 2020
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/338474
https://api.elsevier.com/content/abstract/scopus_id/85085513333
url http://hdl.handle.net/10261/338474
https://api.elsevier.com/content/abstract/scopus_id/85085513333
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/EC//725061
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2017-85494-C2-1-R
Centro de Investigación en Sanidad Animal (CISA)
https://doi.org/10.1016/j.dci.2020.103752
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869421813461680128
score 15,81155

Similares en LA Referencia