The quality of reporting methods and results of cost-effectiveness analyses in Spain: a methodological systematic review

Open Access; Open Peer Review.-- et al.

Detalles Bibliográficos
Autores: Catalá-López, Ferrán, Alonso-Arroyo, Adolfo, Aleixandre-Benavent, Rafael
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2016
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/161607
Acceso en línea:http://hdl.handle.net/10261/161607
Access Level:acceso abierto
Palabra clave:Spain
Reporting
Methodology
Cost-utility analysis
Cost-effectiveness analysis
Quality-adjusted life years
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network_acronym_str ES
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repository_id_str
spelling The quality of reporting methods and results of cost-effectiveness analyses in Spain: a methodological systematic reviewCatalá-López, FerránAlonso-Arroyo, AdolfoAleixandre-Benavent, RafaelSpainReportingMethodologyCost-utility analysisCost-effectiveness analysisQuality-adjusted life yearsOpen Access; Open Peer Review.-- et al.[Background]: Cost-effectiveness analysis has been recognized as an important tool to determine the efficiency of healthcare interventions and services. There is a need for evaluating the reporting of methods and results of cost-effectiveness analyses and establishing their validity. We describe and examine reporting characteristics of methods and results of cost-effectiveness analyses conducted in Spain during more than two decades. [Methods]: A methodological systematic review was conducted with the information obtained through an updated literature review in PubMed and complementary databases (e.g. Scopus, ISI Web of Science, National Health Service Economic Evaluation Database (NHS EED) and Health Technology Assessment (HTA) databases from Centre for Reviews and Dissemination (CRD), Índice Médico Español (IME) Índice Bibliográfico Español en Ciencias de la Salud (IBECS)). We identified cost-effectiveness analyses conducted in Spain that used quality-adjusted life years (QALYs) as outcome measures (period 1989-December 2014). Two reviewers independently extracted the data from each paper. The data were analysed descriptively. [Results]: In total, 223 studies were included. Very few studies (10; 4.5 %) reported working from a protocol. Most studies (200; 89.7 %) were simulation models and included a median of 1000 patients. Only 105 (47.1 %) studies presented an adequate description of the characteristics of the target population. Most study interventions were categorized as therapeutic (189; 84.8 %) and nearly half (111; 49.8 %) considered an active alternative as the comparator. Effectiveness of data was derived from a single study in 87 (39.0 %) reports, and only few (40; 17.9 %) used evidence synthesis-based estimates. Few studies (42; 18.8 %) reported a full description of methods for QALY calculation. The majority of the studies (147; 65.9 %) reported that the study intervention produced >more costs and more QALYs> than the comparator. Most studies (200; 89.7 %) reported favourable conclusions. Main funding source was the private for-profit sector (135; 60.5 %). Conflicts of interest were not disclosed in 88 (39.5 %) studies. [Conclusions]: This methodological review reflects that reporting of several important aspects of methods and results are frequently missing in published cost-effectiveness analyses. Without full and transparent reporting of how studies were designed and conducted, it is difficult to assess the validity of study findings and conclusions.FC-L and RT-S are partially funded by Generalitat Valenciana (PROMETEOII/2015/021), INCLIVA and Institute of Health Carlos III/CIBERSAM. MR, EB-D and SP are partially funded by the Spanish Health Services Research on Chronic Patients Network (REDISSEC). BH is supported by a New Investigator Award from the Canadian Institutes of Health Research and the Drug Safety and Effectiveness Network.Peer ReviewedBioMed CentralCanadian Institutes of Health ResearchInstituto de Salud Carlos IIIInstituto de Salud Carlos IIIGeneralitat ValencianaConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2018201820162018info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/161607reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttps://doi.org/10.1186/s13643-015-0181-5Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/1616072026-05-22T06:33:51Z
dc.title.none.fl_str_mv The quality of reporting methods and results of cost-effectiveness analyses in Spain: a methodological systematic review
title The quality of reporting methods and results of cost-effectiveness analyses in Spain: a methodological systematic review
spellingShingle The quality of reporting methods and results of cost-effectiveness analyses in Spain: a methodological systematic review
Catalá-López, Ferrán
Spain
Reporting
Methodology
Cost-utility analysis
Cost-effectiveness analysis
Quality-adjusted life years
title_short The quality of reporting methods and results of cost-effectiveness analyses in Spain: a methodological systematic review
title_full The quality of reporting methods and results of cost-effectiveness analyses in Spain: a methodological systematic review
title_fullStr The quality of reporting methods and results of cost-effectiveness analyses in Spain: a methodological systematic review
title_full_unstemmed The quality of reporting methods and results of cost-effectiveness analyses in Spain: a methodological systematic review
title_sort The quality of reporting methods and results of cost-effectiveness analyses in Spain: a methodological systematic review
dc.creator.none.fl_str_mv Catalá-López, Ferrán
Alonso-Arroyo, Adolfo
Aleixandre-Benavent, Rafael
author Catalá-López, Ferrán
author_facet Catalá-López, Ferrán
Alonso-Arroyo, Adolfo
Aleixandre-Benavent, Rafael
author_role author
author2 Alonso-Arroyo, Adolfo
Aleixandre-Benavent, Rafael
author2_role author
author
dc.contributor.none.fl_str_mv Canadian Institutes of Health Research
Instituto de Salud Carlos III
Instituto de Salud Carlos III
Generalitat Valenciana
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Spain
Reporting
Methodology
Cost-utility analysis
Cost-effectiveness analysis
Quality-adjusted life years
topic Spain
Reporting
Methodology
Cost-utility analysis
Cost-effectiveness analysis
Quality-adjusted life years
description Open Access; Open Peer Review.-- et al.
publishDate 2016
dc.date.none.fl_str_mv 2016
2018
2018
2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/161607
url http://hdl.handle.net/10261/161607
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://doi.org/10.1186/s13643-015-0181-5
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,81155

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