Synaptic and metabolic gene expression alterations in neurons that are recipients of proteopathic tau seeds

Recent studies suggest that misfolded tau molecules can be released, and taken up by adjacent neurons, propagating proteopathic seeds across neural systems. Yet critical to understanding whether tau propagation is relevant in pathophysiology of disease would be to learn if it alters neuronal propert...

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Detalhes bibliográficos
Autores: Perez-Rando, M, Dujardin, S, Bennett, RE, Commins, C, Nibhanupudy, T, Hyman, BT
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2020
País:España
Recursos:INCLIVA
Repositório:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
OAI Identifier:oai:incliva.fundanetsuite.com:p15264
Acesso em linha:https://incliva.portalinvestigacion.com/publicaciones/15264
Access Level:Acceso aberto
Palavra-chave:Alzheimer's disease
Neurofibrillary tangles
Tau seeding
RNA expression
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spelling Synaptic and metabolic gene expression alterations in neurons that are recipients of proteopathic tau seedsPerez-Rando, MDujardin, SBennett, RECommins, CNibhanupudy, THyman, BTAlzheimer's diseaseNeurofibrillary tanglesTau seedingRNA expressionRecent studies suggest that misfolded tau molecules can be released, and taken up by adjacent neurons, propagating proteopathic seeds across neural systems. Yet critical to understanding whether tau propagation is relevant in pathophysiology of disease would be to learn if it alters neuronal properties. We utilized high resolution multi-color in situ hybridization technology, RNAScope, in a well-established tau transgenic animal, and found that a subset of neurons in the cortex do not appear to express the transgene, but do develop phospho-tau positive inclusions, consistent with having received tau seeds. Recipient neurons show decreases in their expression of synaptophysin, CAMKII alpha, and mouse tau in both young and old animals. These results contrast with neurons that develop tau aggregates and also overexpress the transgene, which have few changes in expression of metabolic and synaptic markers. Taken together, these results strongly suggest that tau propagation impacts neuronal functional integrity.BMC2020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://incliva.portalinvestigacion.com/publicaciones/15264Acta Neuropathologica CommunicationsISSN: 20515960reponame:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVAinstname:INCLIVAInglésinfo:eu-repo/semantics/openAccessoai:incliva.fundanetsuite.com:p152642026-06-07T16:35:31Z
dc.title.none.fl_str_mv Synaptic and metabolic gene expression alterations in neurons that are recipients of proteopathic tau seeds
title Synaptic and metabolic gene expression alterations in neurons that are recipients of proteopathic tau seeds
spellingShingle Synaptic and metabolic gene expression alterations in neurons that are recipients of proteopathic tau seeds
Perez-Rando, M
Alzheimer's disease
Neurofibrillary tangles
Tau seeding
RNA expression
title_short Synaptic and metabolic gene expression alterations in neurons that are recipients of proteopathic tau seeds
title_full Synaptic and metabolic gene expression alterations in neurons that are recipients of proteopathic tau seeds
title_fullStr Synaptic and metabolic gene expression alterations in neurons that are recipients of proteopathic tau seeds
title_full_unstemmed Synaptic and metabolic gene expression alterations in neurons that are recipients of proteopathic tau seeds
title_sort Synaptic and metabolic gene expression alterations in neurons that are recipients of proteopathic tau seeds
dc.creator.none.fl_str_mv Perez-Rando, M
Dujardin, S
Bennett, RE
Commins, C
Nibhanupudy, T
Hyman, BT
author Perez-Rando, M
author_facet Perez-Rando, M
Dujardin, S
Bennett, RE
Commins, C
Nibhanupudy, T
Hyman, BT
author_role author
author2 Dujardin, S
Bennett, RE
Commins, C
Nibhanupudy, T
Hyman, BT
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Alzheimer's disease
Neurofibrillary tangles
Tau seeding
RNA expression
topic Alzheimer's disease
Neurofibrillary tangles
Tau seeding
RNA expression
description Recent studies suggest that misfolded tau molecules can be released, and taken up by adjacent neurons, propagating proteopathic seeds across neural systems. Yet critical to understanding whether tau propagation is relevant in pathophysiology of disease would be to learn if it alters neuronal properties. We utilized high resolution multi-color in situ hybridization technology, RNAScope, in a well-established tau transgenic animal, and found that a subset of neurons in the cortex do not appear to express the transgene, but do develop phospho-tau positive inclusions, consistent with having received tau seeds. Recipient neurons show decreases in their expression of synaptophysin, CAMKII alpha, and mouse tau in both young and old animals. These results contrast with neurons that develop tau aggregates and also overexpress the transgene, which have few changes in expression of metabolic and synaptic markers. Taken together, these results strongly suggest that tau propagation impacts neuronal functional integrity.
publishDate 2020
dc.date.none.fl_str_mv 2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://incliva.portalinvestigacion.com/publicaciones/15264
url https://incliva.portalinvestigacion.com/publicaciones/15264
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv BMC
publisher.none.fl_str_mv BMC
dc.source.none.fl_str_mv Acta Neuropathologica Communications
ISSN: 20515960
reponame:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
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