Novel association of the obesity risk-allele near Fas Apoptotic Inhibitory Molecule 2 (FAIM2) gene with heart rate and study of its effects on myocardial infarction in diabetic participants of the PREDIMED trial
BACKGROUND: The Fas apoptotic pathway has been implicated in type 2 diabetes and cardiovascular disease. Although a polymorphism (rs7138803; G > A) near the Fas apoptotic inhibitory molecule 2 (FAIM2) locus has been related to obesity, its association with other cardiovascular risk factors and di...
| Autores: | , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2014 |
| País: | España |
| Recursos: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:2445/108628 |
| Acesso em linha: | https://hdl.handle.net/2445/108628 |
| Access Level: | acceso abierto |
| Palavra-chave: | Obesitat Infart de miocardi Diabetis Hàbits alimentaris Cuina mediterrània Assaigs clínics Obesity Myocardial infarction Diabetes Food habits Mediterranean cooking Clinical trials |
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Novel association of the obesity risk-allele near Fas Apoptotic Inhibitory Molecule 2 (FAIM2) gene with heart rate and study of its effects on myocardial infarction in diabetic participants of the PREDIMED trialCorella Piquer, DoloresSorlí, José V.González, José I.Ortega Azorín, CarolinaFitó Colomer, MontserratBulló, MònicaMartínez-González, Miguel Ángel, 1957-Ros Rahola, EmilioArós, FernandoLapetra, JoséGómez Gracia, EnriqueSerra Majem, LluísRuiz-Gutiérrez, ValentinaFiol Sala, MiguelColtell, ÓscarVinyoles, ErnestPintó Sala, XavierMartí, AmeliaSaiz, CarmenOrdovás, José MaríaEstruch Riba, RamonObesitatInfart de miocardiDiabetisHàbits alimentarisCuina mediterràniaAssaigs clínicsObesityMyocardial infarctionDiabetesFood habitsMediterranean cookingClinical trialsBACKGROUND: The Fas apoptotic pathway has been implicated in type 2 diabetes and cardiovascular disease. Although a polymorphism (rs7138803; G > A) near the Fas apoptotic inhibitory molecule 2 (FAIM2) locus has been related to obesity, its association with other cardiovascular risk factors and disease remains uncertain. METHODS: We analyzed the association between the FAIM2-rs7138803 polymorphism and obesity, blood pressure and heart rate in 7,161 participants (48.3% with type 2 diabetes) in the PREDIMED study at baseline. We also explored gene-diet interactions with adherence to the Mediterranean diet (MedDiet) and examined the effects of the polymorphism on cardiovascular disease incidence per diabetes status after a median 4.8-year dietary intervention (MedDiet versus control group) follow-up. RESULTS: We replicated the association between the FAIM2-rs7138803 polymorphism and greater obesity risk (OR: 1.08; 95% CI: 1.01-1.16; P = 0.011; per-A allele). Moreover, we detected novel associations of this polymorphism with higher diastolic blood pressure (DBP) and heart rate at baseline (B = 1.07; 95% CI: 0.97-1.28 bmp in AA vs G-carriers for the whole population), that remained statistically significant even after adjustment for body mass index (P = 0.012) and correction for multiple comparisons. This association was greater and statistically significant in type-2 diabetic subjects (B = 1.44: 95% CI: 0.23-2.56 bmp; P = 0.010 for AA versus G-carriers). Likewise, these findings were also observed longitudinally over 5-year follow-up. Nevertheless, we found no statistically significant gene-diet interactions with MedDiet for this trait. On analyzing myocardial infarction risk, we detected a nominally significant (P = 0.041) association in type-2 diabetic subjects (HR: 1.86; 95% CI:1.03-3.37 for AA versus G-carriers), although this association did not remain statistically significant following correction for multiple comparisons. CONCLUSIONS: We confirmed the FAIM2-rs7138803 relationship with obesity and identified novel and consistent associations with heart rate in particular in type 2 diabetic subjects. Furthermore, our results suggest a possible association of this polymorphism with higher myocardial infarction risk in type-2 diabetic subjects, although this result needs to be replicated as it could represent a false positive.BioMed Central2017201720142017info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion13 p.application/pdfhttps://hdl.handle.net/2445/108628Articles publicats en revistes (Medicina)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1186/1475-2840-13-5Cardiovascular Diabetology, 2014, vol. 13, num. 5, p. 1-13https://doi.org/10.1186/1475-2840-13-5cc-by (c) Corella, Dolores et al., 2014http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:recercat.cat:2445/1086282026-05-29T05:05:01Z |
| dc.title.none.fl_str_mv |
Novel association of the obesity risk-allele near Fas Apoptotic Inhibitory Molecule 2 (FAIM2) gene with heart rate and study of its effects on myocardial infarction in diabetic participants of the PREDIMED trial |
| title |
Novel association of the obesity risk-allele near Fas Apoptotic Inhibitory Molecule 2 (FAIM2) gene with heart rate and study of its effects on myocardial infarction in diabetic participants of the PREDIMED trial |
| spellingShingle |
Novel association of the obesity risk-allele near Fas Apoptotic Inhibitory Molecule 2 (FAIM2) gene with heart rate and study of its effects on myocardial infarction in diabetic participants of the PREDIMED trial Corella Piquer, Dolores Obesitat Infart de miocardi Diabetis Hàbits alimentaris Cuina mediterrània Assaigs clínics Obesity Myocardial infarction Diabetes Food habits Mediterranean cooking Clinical trials |
| title_short |
Novel association of the obesity risk-allele near Fas Apoptotic Inhibitory Molecule 2 (FAIM2) gene with heart rate and study of its effects on myocardial infarction in diabetic participants of the PREDIMED trial |
| title_full |
Novel association of the obesity risk-allele near Fas Apoptotic Inhibitory Molecule 2 (FAIM2) gene with heart rate and study of its effects on myocardial infarction in diabetic participants of the PREDIMED trial |
| title_fullStr |
Novel association of the obesity risk-allele near Fas Apoptotic Inhibitory Molecule 2 (FAIM2) gene with heart rate and study of its effects on myocardial infarction in diabetic participants of the PREDIMED trial |
| title_full_unstemmed |
Novel association of the obesity risk-allele near Fas Apoptotic Inhibitory Molecule 2 (FAIM2) gene with heart rate and study of its effects on myocardial infarction in diabetic participants of the PREDIMED trial |
| title_sort |
Novel association of the obesity risk-allele near Fas Apoptotic Inhibitory Molecule 2 (FAIM2) gene with heart rate and study of its effects on myocardial infarction in diabetic participants of the PREDIMED trial |
| dc.creator.none.fl_str_mv |
Corella Piquer, Dolores Sorlí, José V. González, José I. Ortega Azorín, Carolina Fitó Colomer, Montserrat Bulló, Mònica Martínez-González, Miguel Ángel, 1957- Ros Rahola, Emilio Arós, Fernando Lapetra, José Gómez Gracia, Enrique Serra Majem, Lluís Ruiz-Gutiérrez, Valentina Fiol Sala, Miguel Coltell, Óscar Vinyoles, Ernest Pintó Sala, Xavier Martí, Amelia Saiz, Carmen Ordovás, José María Estruch Riba, Ramon |
| author |
Corella Piquer, Dolores |
| author_facet |
Corella Piquer, Dolores Sorlí, José V. González, José I. Ortega Azorín, Carolina Fitó Colomer, Montserrat Bulló, Mònica Martínez-González, Miguel Ángel, 1957- Ros Rahola, Emilio Arós, Fernando Lapetra, José Gómez Gracia, Enrique Serra Majem, Lluís Ruiz-Gutiérrez, Valentina Fiol Sala, Miguel Coltell, Óscar Vinyoles, Ernest Pintó Sala, Xavier Martí, Amelia Saiz, Carmen Ordovás, José María Estruch Riba, Ramon |
| author_role |
author |
| author2 |
Sorlí, José V. González, José I. Ortega Azorín, Carolina Fitó Colomer, Montserrat Bulló, Mònica Martínez-González, Miguel Ángel, 1957- Ros Rahola, Emilio Arós, Fernando Lapetra, José Gómez Gracia, Enrique Serra Majem, Lluís Ruiz-Gutiérrez, Valentina Fiol Sala, Miguel Coltell, Óscar Vinyoles, Ernest Pintó Sala, Xavier Martí, Amelia Saiz, Carmen Ordovás, José María Estruch Riba, Ramon |
| author2_role |
author author author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Obesitat Infart de miocardi Diabetis Hàbits alimentaris Cuina mediterrània Assaigs clínics Obesity Myocardial infarction Diabetes Food habits Mediterranean cooking Clinical trials |
| topic |
Obesitat Infart de miocardi Diabetis Hàbits alimentaris Cuina mediterrània Assaigs clínics Obesity Myocardial infarction Diabetes Food habits Mediterranean cooking Clinical trials |
| description |
BACKGROUND: The Fas apoptotic pathway has been implicated in type 2 diabetes and cardiovascular disease. Although a polymorphism (rs7138803; G > A) near the Fas apoptotic inhibitory molecule 2 (FAIM2) locus has been related to obesity, its association with other cardiovascular risk factors and disease remains uncertain. METHODS: We analyzed the association between the FAIM2-rs7138803 polymorphism and obesity, blood pressure and heart rate in 7,161 participants (48.3% with type 2 diabetes) in the PREDIMED study at baseline. We also explored gene-diet interactions with adherence to the Mediterranean diet (MedDiet) and examined the effects of the polymorphism on cardiovascular disease incidence per diabetes status after a median 4.8-year dietary intervention (MedDiet versus control group) follow-up. RESULTS: We replicated the association between the FAIM2-rs7138803 polymorphism and greater obesity risk (OR: 1.08; 95% CI: 1.01-1.16; P = 0.011; per-A allele). Moreover, we detected novel associations of this polymorphism with higher diastolic blood pressure (DBP) and heart rate at baseline (B = 1.07; 95% CI: 0.97-1.28 bmp in AA vs G-carriers for the whole population), that remained statistically significant even after adjustment for body mass index (P = 0.012) and correction for multiple comparisons. This association was greater and statistically significant in type-2 diabetic subjects (B = 1.44: 95% CI: 0.23-2.56 bmp; P = 0.010 for AA versus G-carriers). Likewise, these findings were also observed longitudinally over 5-year follow-up. Nevertheless, we found no statistically significant gene-diet interactions with MedDiet for this trait. On analyzing myocardial infarction risk, we detected a nominally significant (P = 0.041) association in type-2 diabetic subjects (HR: 1.86; 95% CI:1.03-3.37 for AA versus G-carriers), although this association did not remain statistically significant following correction for multiple comparisons. CONCLUSIONS: We confirmed the FAIM2-rs7138803 relationship with obesity and identified novel and consistent associations with heart rate in particular in type 2 diabetic subjects. Furthermore, our results suggest a possible association of this polymorphism with higher myocardial infarction risk in type-2 diabetic subjects, although this result needs to be replicated as it could represent a false positive. |
| publishDate |
2014 |
| dc.date.none.fl_str_mv |
2014 2017 2017 2017 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/2445/108628 |
| url |
https://hdl.handle.net/2445/108628 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
Reproducció del document publicat a: https://doi.org/10.1186/1475-2840-13-5 Cardiovascular Diabetology, 2014, vol. 13, num. 5, p. 1-13 https://doi.org/10.1186/1475-2840-13-5 |
| dc.rights.none.fl_str_mv |
cc-by (c) Corella, Dolores et al., 2014 http://creativecommons.org/licenses/by/3.0/es info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
cc-by (c) Corella, Dolores et al., 2014 http://creativecommons.org/licenses/by/3.0/es |
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openAccess |
| dc.format.none.fl_str_mv |
13 p. application/pdf |
| dc.publisher.none.fl_str_mv |
BioMed Central |
| publisher.none.fl_str_mv |
BioMed Central |
| dc.source.none.fl_str_mv |
Articles publicats en revistes (Medicina) reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
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Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
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Recercat. Dipósit de la Recerca de Catalunya |
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Recercat. Dipósit de la Recerca de Catalunya |
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1869421798855016448 |
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15,812429 |