Lighting conditions during suckling modify rat pupillary light responses but not entrainment to 24-hour sawtooth dim light-dark cycles

Early-life experiences have lasting consequences on future health. This study examined the impact of bright light exposure during suckling on non-image-forming system responses, specifically the pupillary light reflex (PLR) and circadian entrainment. Wistar rats were exposed to either constant brigh...

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Detalhes bibliográficos
Autores: Cambras Riu, Trinitat, Díez Noguera, Antoni
Tipo de documento: artigo
Estado:Versión aceptada para publicación
Data de publicação:2025
País:España
Recursos:Universidad de Barcelona
Repositório:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/226111
Acesso em linha:https://hdl.handle.net/2445/226111
Access Level:Acesso embargado
Palavra-chave:Ritmes circadiaris
Alletament
Llum
Circadian rhythms
Breastfeeding
Light
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spelling Lighting conditions during suckling modify rat pupillary light responses but not entrainment to 24-hour sawtooth dim light-dark cyclesCambras Riu, TrinitatDíez Noguera, AntoniRitmes circadiarisAlletamentLlumCircadian rhythmsBreastfeedingLightEarly-life experiences have lasting consequences on future health. This study examined the impact of bright light exposure during suckling on non-image-forming system responses, specifically the pupillary light reflex (PLR) and circadian entrainment. Wistar rats were exposed to either constant bright light (SLL-rats) or 24-hour light-dark cycles (SLD-rats) during suckling. After weaning, all rats were maintained under identical conditions, experiencing different 24-hour sawtooth light-dark cycles (light: dim light, 1 µW/cm2; dark: 0.03 µW/cm2 red light) for three months. PLR was tested using 30-second blue light pulses at intensities of 3, 10, 30, 100, and 300 µW/cm2. Results showed that PLR was influenced by early-life lighting conditions. SLL-rats exhibited a linear response across all light intensities, with significantly reduced pupillary contraction compared to SLD-rats at 3, 10, 30, and 100 µW/cm2, while no differences were observed at 300 µW/cm2. Additionally, exposure to different 24-hour sawtooth cycles led to minor differences in circadian rhythm shape and entrainment, which did not correspond to the PLR differences or the manifestation of rhythms under LL in adulthood. These findings suggest that early-life lighting conditions may induce functional alterations in specific aspects of the non-image-forming system, potentially affecting physiology and behavior in adulthood.Swets & Zeitlinger, BV2025info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfhttps://hdl.handle.net/2445/226111Articles publicats en revistes (Bioquímica i Fisiologia)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésVersió postprint del document publicat a: https://doi.org/10.1080/09291016.2025.2576097Biological Rhythm Research, 2025https://doi.org/10.1080/09291016.2025.2576097(c) Swets & Zeitlinger, BV, 2025info:eu-repo/semantics/embargoedAccessoai:diposit.ub.edu:2445/2261112026-05-27T06:46:51Z
dc.title.none.fl_str_mv Lighting conditions during suckling modify rat pupillary light responses but not entrainment to 24-hour sawtooth dim light-dark cycles
title Lighting conditions during suckling modify rat pupillary light responses but not entrainment to 24-hour sawtooth dim light-dark cycles
spellingShingle Lighting conditions during suckling modify rat pupillary light responses but not entrainment to 24-hour sawtooth dim light-dark cycles
Cambras Riu, Trinitat
Ritmes circadiaris
Alletament
Llum
Circadian rhythms
Breastfeeding
Light
title_short Lighting conditions during suckling modify rat pupillary light responses but not entrainment to 24-hour sawtooth dim light-dark cycles
title_full Lighting conditions during suckling modify rat pupillary light responses but not entrainment to 24-hour sawtooth dim light-dark cycles
title_fullStr Lighting conditions during suckling modify rat pupillary light responses but not entrainment to 24-hour sawtooth dim light-dark cycles
title_full_unstemmed Lighting conditions during suckling modify rat pupillary light responses but not entrainment to 24-hour sawtooth dim light-dark cycles
title_sort Lighting conditions during suckling modify rat pupillary light responses but not entrainment to 24-hour sawtooth dim light-dark cycles
dc.creator.none.fl_str_mv Cambras Riu, Trinitat
Díez Noguera, Antoni
author Cambras Riu, Trinitat
author_facet Cambras Riu, Trinitat
Díez Noguera, Antoni
author_role author
author2 Díez Noguera, Antoni
author2_role author
dc.subject.none.fl_str_mv Ritmes circadiaris
Alletament
Llum
Circadian rhythms
Breastfeeding
Light
topic Ritmes circadiaris
Alletament
Llum
Circadian rhythms
Breastfeeding
Light
description Early-life experiences have lasting consequences on future health. This study examined the impact of bright light exposure during suckling on non-image-forming system responses, specifically the pupillary light reflex (PLR) and circadian entrainment. Wistar rats were exposed to either constant bright light (SLL-rats) or 24-hour light-dark cycles (SLD-rats) during suckling. After weaning, all rats were maintained under identical conditions, experiencing different 24-hour sawtooth light-dark cycles (light: dim light, 1 µW/cm2; dark: 0.03 µW/cm2 red light) for three months. PLR was tested using 30-second blue light pulses at intensities of 3, 10, 30, 100, and 300 µW/cm2. Results showed that PLR was influenced by early-life lighting conditions. SLL-rats exhibited a linear response across all light intensities, with significantly reduced pupillary contraction compared to SLD-rats at 3, 10, 30, and 100 µW/cm2, while no differences were observed at 300 µW/cm2. Additionally, exposure to different 24-hour sawtooth cycles led to minor differences in circadian rhythm shape and entrainment, which did not correspond to the PLR differences or the manifestation of rhythms under LL in adulthood. These findings suggest that early-life lighting conditions may induce functional alterations in specific aspects of the non-image-forming system, potentially affecting physiology and behavior in adulthood.
publishDate 2025
dc.date.none.fl_str_mv 2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/226111
url https://hdl.handle.net/2445/226111
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Versió postprint del document publicat a: https://doi.org/10.1080/09291016.2025.2576097
Biological Rhythm Research, 2025
https://doi.org/10.1080/09291016.2025.2576097
dc.rights.none.fl_str_mv (c) Swets & Zeitlinger, BV, 2025
info:eu-repo/semantics/embargoedAccess
rights_invalid_str_mv (c) Swets & Zeitlinger, BV, 2025
eu_rights_str_mv embargoedAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Swets & Zeitlinger, BV
publisher.none.fl_str_mv Swets & Zeitlinger, BV
dc.source.none.fl_str_mv Articles publicats en revistes (Bioquímica i Fisiologia)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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