Alkylglycerols reduce serum complement and plasma vascular endothelial growth factor in obese individuals

Alkylglycerols (AKGs), isolated or present in shark liver oil have anti-inflammatory properties. Complement 3 (C3) and 4 (C4) participate in lipid metabolism and in obesity, contributing to the metabolic syndrome and to the low-grade inflammation associated with obesity. In a randomized, controlled,...

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Autores: Parri, Alejandra, Fitó Colomer, Montserrat, Torres, C. F., Muñoz-Aguayo, D., Schröder, Helmut, 1958-, Cano, J. F., Vázquez, Luis Alberto, Reglero, G., Covas Planells, Maria Isabel
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2016
País:España
Institución:Universitat Pompeu Fabra
Repositorio:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/33675
Acceso en línea:http://hdl.handle.net/10230/33675
http://dx.doi.org/10.1007/s10787-016-0265-4
Access Level:acceso abierto
Palabra clave:Obesitat
Alkylglycerols
Complement 3
Complement 4
Inflammation
Obesity
Vascular endothelial growth factor
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spelling Alkylglycerols reduce serum complement and plasma vascular endothelial growth factor in obese individualsParri, AlejandraFitó Colomer, MontserratTorres, C. F.Muñoz-Aguayo, D.Schröder, Helmut, 1958-Cano, J. F.Vázquez, Luis AlbertoReglero, G.Covas Planells, Maria IsabelObesitatAlkylglycerolsComplement 3Complement 4InflammationObesityVascular endothelial growth factorAlkylglycerols (AKGs), isolated or present in shark liver oil have anti-inflammatory properties. Complement 3 (C3) and 4 (C4) participate in lipid metabolism and in obesity, contributing to the metabolic syndrome and to the low-grade inflammation associated with obesity. In a randomized, controlled, crossover study, 26 non-diabetes obese individuals were assigned two preparations with low (LAC, 10 mg AKGs) and high (HAC, 20 mg AKGs) AKG content. Intervention periods were of 3 weeks preceded by 2-week washout periods in which shark liver oil was avoided. Cholesterol, C3, C4, and vascular endothelial growth factor (VEGF) decreased in a linear trend (P < 0.01) from baseline (control) to LAC and HAC. Values after HAC were significantly lower (P < 0.05) versus both baseline and after LAC. No adverse effects were observed or reported. Data from this pilot study open a promising field for the study of the beneficial effects of AKGs on cardiovascular risk factors in obese individuals.This work has been done in the context of the University of Barcelona (UB), PhD Research Program in Dietetics and Nutrition (EEES H0502). It was supported by the Spanish Ministry of Science and Innovation/FEDER (European Regional Development Found-ERDF) financing the project AGL2006-02031, by Instituto de Salud Carlos III Miguel Servet’s contract (CP06/00100), and partially supported by the Agència de Gestió Ajuts Universitaris de Recerca 2009 SGR 1195. CIBEROBN and CIBERESP are initiatives of Instituto de Salud Carlos III, Madrid, Spain.Elsevier201820182016info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/33675http://dx.doi.org/10.1007/s10787-016-0265-4reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésInflammopharmacology. 2016 Jun;24(2-3):127-31info:eu-repo/grantAgreement/ES/2PN/AGL2006-02031© Elsevier http://dx.doi.org/10.1007/s10787-016-0265-4info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/336752026-06-12T07:21:37Z
dc.title.none.fl_str_mv Alkylglycerols reduce serum complement and plasma vascular endothelial growth factor in obese individuals
title Alkylglycerols reduce serum complement and plasma vascular endothelial growth factor in obese individuals
spellingShingle Alkylglycerols reduce serum complement and plasma vascular endothelial growth factor in obese individuals
Parri, Alejandra
Obesitat
Alkylglycerols
Complement 3
Complement 4
Inflammation
Obesity
Vascular endothelial growth factor
title_short Alkylglycerols reduce serum complement and plasma vascular endothelial growth factor in obese individuals
title_full Alkylglycerols reduce serum complement and plasma vascular endothelial growth factor in obese individuals
title_fullStr Alkylglycerols reduce serum complement and plasma vascular endothelial growth factor in obese individuals
title_full_unstemmed Alkylglycerols reduce serum complement and plasma vascular endothelial growth factor in obese individuals
title_sort Alkylglycerols reduce serum complement and plasma vascular endothelial growth factor in obese individuals
dc.creator.none.fl_str_mv Parri, Alejandra
Fitó Colomer, Montserrat
Torres, C. F.
Muñoz-Aguayo, D.
Schröder, Helmut, 1958-
Cano, J. F.
Vázquez, Luis Alberto
Reglero, G.
Covas Planells, Maria Isabel
author Parri, Alejandra
author_facet Parri, Alejandra
Fitó Colomer, Montserrat
Torres, C. F.
Muñoz-Aguayo, D.
Schröder, Helmut, 1958-
Cano, J. F.
Vázquez, Luis Alberto
Reglero, G.
Covas Planells, Maria Isabel
author_role author
author2 Fitó Colomer, Montserrat
Torres, C. F.
Muñoz-Aguayo, D.
Schröder, Helmut, 1958-
Cano, J. F.
Vázquez, Luis Alberto
Reglero, G.
Covas Planells, Maria Isabel
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Obesitat
Alkylglycerols
Complement 3
Complement 4
Inflammation
Obesity
Vascular endothelial growth factor
topic Obesitat
Alkylglycerols
Complement 3
Complement 4
Inflammation
Obesity
Vascular endothelial growth factor
description Alkylglycerols (AKGs), isolated or present in shark liver oil have anti-inflammatory properties. Complement 3 (C3) and 4 (C4) participate in lipid metabolism and in obesity, contributing to the metabolic syndrome and to the low-grade inflammation associated with obesity. In a randomized, controlled, crossover study, 26 non-diabetes obese individuals were assigned two preparations with low (LAC, 10 mg AKGs) and high (HAC, 20 mg AKGs) AKG content. Intervention periods were of 3 weeks preceded by 2-week washout periods in which shark liver oil was avoided. Cholesterol, C3, C4, and vascular endothelial growth factor (VEGF) decreased in a linear trend (P < 0.01) from baseline (control) to LAC and HAC. Values after HAC were significantly lower (P < 0.05) versus both baseline and after LAC. No adverse effects were observed or reported. Data from this pilot study open a promising field for the study of the beneficial effects of AKGs on cardiovascular risk factors in obese individuals.
publishDate 2016
dc.date.none.fl_str_mv 2016
2018
2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/33675
http://dx.doi.org/10.1007/s10787-016-0265-4
url http://hdl.handle.net/10230/33675
http://dx.doi.org/10.1007/s10787-016-0265-4
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Inflammopharmacology. 2016 Jun;24(2-3):127-31
info:eu-repo/grantAgreement/ES/2PN/AGL2006-02031
dc.rights.none.fl_str_mv © Elsevier http://dx.doi.org/10.1007/s10787-016-0265-4
info:eu-repo/semantics/openAccess
rights_invalid_str_mv © Elsevier http://dx.doi.org/10.1007/s10787-016-0265-4
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositorio Digital de la UPF
instname:Universitat Pompeu Fabra
instname_str Universitat Pompeu Fabra
reponame_str Repositorio Digital de la UPF
collection Repositorio Digital de la UPF
repository.name.fl_str_mv
repository.mail.fl_str_mv
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