Exploring biomarkers of regular wine consumption in human urine: Targeted and untargeted metabolomics approaches

The epidemiological assessment of wine consumption usually has been obtained using self-reporting questionnaires. In this study, two metabolomic approaches, targeted and untargeted, were applied to 24-h urine samples from a cohort of La Rioja (Spain) (aged 52-78), comparing moderate and daily wine c...

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Detalles Bibliográficos
Autores: Jiménez-Salcedo Marta, Manzano, José Ignacio, Yuste, Silvia, Íñiguez, María, Pérez-Matute, Patricia, Motilva, María-José
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/380582
Acceso en línea:http://hdl.handle.net/10261/380582
https://api.elsevier.com/content/abstract/scopus_id/85212940127
Access Level:acceso abierto
Palabra clave:Targeted metabolomics
Untargeted metabolomics
Urine metabolome
Wine consumption biomarkers
Wine phenol metabolites
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spelling Exploring biomarkers of regular wine consumption in human urine: Targeted and untargeted metabolomics approachesJiménez-Salcedo MartaManzano, José IgnacioYuste, SilviaÍñiguez, MaríaPérez-Matute, PatriciaMotilva, María-JoséTargeted metabolomicsUntargeted metabolomicsUrine metabolomeWine consumption biomarkersWine phenol metabolitesThe epidemiological assessment of wine consumption usually has been obtained using self-reporting questionnaires. In this study, two metabolomic approaches, targeted and untargeted, were applied to 24-h urine samples from a cohort of La Rioja (Spain) (aged 52-78), comparing moderate and daily wine consumers (20 males and 13 females) without diet intervention, versus non-consumers (8 males and 35 females). Results showed that the non-targeted metabolomics approach has allowed for the annotation of sixteen compounds in 24-h urine samples from regular wine-consumers that were not detected in the urine of non-wine consumers. Additionally, the targeted metabolomics approach showed a wide range of phenol metabolites, mainly hepatic phase-II conjugates, whose concentration was significantly higher in the urine of wine consumers. As a novelty, this study focuses on discovering the main urinary biomarkers of regular wine consumption involving free-living volunteers, without dietary intervention or restrictions that might alter their regular behaviors and lifestyles.This study was financially supported by Grant PID2019-108851RB-C22 funded by Spanish Ministry of Science and Innovation (MCIN/AEI/10.13039/501100011033). Marta Jiménez-Salcedo and Silvia Yuste acknowledge the financial support of the University of La Rioja and the University of Lleida, respectively, for their post-doctoral “Margarita Salas” grants financed by the European Union-NextGenerationEU. The authors are grateful to the technical staff (Nuria Pérez del Notario and Miguel Ángel Fernández-Recio) of the Instrumental Analysis Service at the ICVV for their UPLC-QTOF-MS analytical and technical support.Peer reviewedElsevier BVAgencia Estatal de Investigación (España)Ministerio de Ciencia, Innovación y Universidades (España)Universidad de La RiojaUniversidad de LleidaEuropean CommissionConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202520252025info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/380582https://api.elsevier.com/content/abstract/scopus_id/85212940127reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-108851RB-C22Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3805822026-05-22T06:33:51Z
dc.title.none.fl_str_mv Exploring biomarkers of regular wine consumption in human urine: Targeted and untargeted metabolomics approaches
title Exploring biomarkers of regular wine consumption in human urine: Targeted and untargeted metabolomics approaches
spellingShingle Exploring biomarkers of regular wine consumption in human urine: Targeted and untargeted metabolomics approaches
Jiménez-Salcedo Marta
Targeted metabolomics
Untargeted metabolomics
Urine metabolome
Wine consumption biomarkers
Wine phenol metabolites
title_short Exploring biomarkers of regular wine consumption in human urine: Targeted and untargeted metabolomics approaches
title_full Exploring biomarkers of regular wine consumption in human urine: Targeted and untargeted metabolomics approaches
title_fullStr Exploring biomarkers of regular wine consumption in human urine: Targeted and untargeted metabolomics approaches
title_full_unstemmed Exploring biomarkers of regular wine consumption in human urine: Targeted and untargeted metabolomics approaches
title_sort Exploring biomarkers of regular wine consumption in human urine: Targeted and untargeted metabolomics approaches
dc.creator.none.fl_str_mv Jiménez-Salcedo Marta
Manzano, José Ignacio
Yuste, Silvia
Íñiguez, María
Pérez-Matute, Patricia
Motilva, María-José
author Jiménez-Salcedo Marta
author_facet Jiménez-Salcedo Marta
Manzano, José Ignacio
Yuste, Silvia
Íñiguez, María
Pérez-Matute, Patricia
Motilva, María-José
author_role author
author2 Manzano, José Ignacio
Yuste, Silvia
Íñiguez, María
Pérez-Matute, Patricia
Motilva, María-José
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Agencia Estatal de Investigación (España)
Ministerio de Ciencia, Innovación y Universidades (España)
Universidad de La Rioja
Universidad de Lleida
European Commission
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Targeted metabolomics
Untargeted metabolomics
Urine metabolome
Wine consumption biomarkers
Wine phenol metabolites
topic Targeted metabolomics
Untargeted metabolomics
Urine metabolome
Wine consumption biomarkers
Wine phenol metabolites
description The epidemiological assessment of wine consumption usually has been obtained using self-reporting questionnaires. In this study, two metabolomic approaches, targeted and untargeted, were applied to 24-h urine samples from a cohort of La Rioja (Spain) (aged 52-78), comparing moderate and daily wine consumers (20 males and 13 females) without diet intervention, versus non-consumers (8 males and 35 females). Results showed that the non-targeted metabolomics approach has allowed for the annotation of sixteen compounds in 24-h urine samples from regular wine-consumers that were not detected in the urine of non-wine consumers. Additionally, the targeted metabolomics approach showed a wide range of phenol metabolites, mainly hepatic phase-II conjugates, whose concentration was significantly higher in the urine of wine consumers. As a novelty, this study focuses on discovering the main urinary biomarkers of regular wine consumption involving free-living volunteers, without dietary intervention or restrictions that might alter their regular behaviors and lifestyles.
publishDate 2025
dc.date.none.fl_str_mv 2025
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/380582
https://api.elsevier.com/content/abstract/scopus_id/85212940127
url http://hdl.handle.net/10261/380582
https://api.elsevier.com/content/abstract/scopus_id/85212940127
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-108851RB-C22
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier BV
publisher.none.fl_str_mv Elsevier BV
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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