Squamous intraepithelial lesions of the anal squamocolumnar junction: Histopathological classification and HPV genotyping

Background: Human papillomavirus (HPV)-related anal cancer lesions are often found adjacent to the squamocolumnar junction (SCJ). We have assessed the histopathology and associated HPV genotypes in anal SCJ lesions in surgically excised anal warts in HIV-negative and -positive patients. Methods: His...

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Autores: Clavero, Omar, McCloskey, Jenny, Molina, Vicente Marco, Quirós, Beatriz, Bravo, Ignacio G., Sanjosé Llongueras, Silvia de, Bosch José, Francesc Xavier, 1947-, Pimenoff, Ville Nikolai
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2017
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/124388
Acceso en línea:https://hdl.handle.net/2445/124388
Access Level:acceso abierto
Palabra clave:Epiteli
Papil·lomavirus
Epithelium
Papillomaviruses
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spelling Squamous intraepithelial lesions of the anal squamocolumnar junction: Histopathological classification and HPV genotypingClavero, OmarMcCloskey, JennyMolina, Vicente MarcoQuirós, BeatrizBravo, Ignacio G.Sanjosé Llongueras, Silvia deBosch José, Francesc Xavier, 1947-Pimenoff, Ville NikolaiEpiteliPapil·lomavirusEpitheliumPapillomavirusesBackground: Human papillomavirus (HPV)-related anal cancer lesions are often found adjacent to the squamocolumnar junction (SCJ). We have assessed the histopathology and associated HPV genotypes in anal SCJ lesions in surgically excised anal warts in HIV-negative and -positive patients. Methods: Histopathology identified 47 squamous intraepithelial lesions (SILs) adjacent to the SCJ amongst a total of 145 cases of clinically diagnosed anal condylomata. The anal SCJ lesions were further analyzed with p16, CK7 and p63 immunohistochemistry and HPV genotyping. Results: Sixteen (16/47) of the excised anal wart lesions contained HSIL; Three were HSIL and exclusively associated with oncogenic HPVs. A further thirteen (13/47) were mixed lesions. Of these eight were HSILs with LSIL and six were HSILs with papillary immature metaplasia (PIM); Ten of the mixed lesions were associated with one or more oncogenic HPVs, while three cases were exclusively associated with HPV6. Conclusions: Clinically diagnosed anal warts cannot be assumed to be limited to low-grade lesions as anal warts of the SCJ often show heterogeneous lesions, with coexistence of LSIL, PIM, and HSIL. Lesions showing PIM, however, may mimic HSIL, because they are hypercellular, but lack the nuclear atypia and conspicuous mitotic activity of HSIL; and are p16 negative.Elsevier Science2018201820172018info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion7 p.application/pdfhttps://hdl.handle.net/2445/124388Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1016/j.pvr.2016.12.001Papillomavirus Research, 2017, vol. 3, p. 11-17https://doi.org/10.1016/j.pvr.2016.12.001cc by-nc-nd (c) Clavero et al., 2017http://creativecommons.org/licenses/by-nc-nd/3.0/es/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1243882026-05-29T05:05:01Z
dc.title.none.fl_str_mv Squamous intraepithelial lesions of the anal squamocolumnar junction: Histopathological classification and HPV genotyping
title Squamous intraepithelial lesions of the anal squamocolumnar junction: Histopathological classification and HPV genotyping
spellingShingle Squamous intraepithelial lesions of the anal squamocolumnar junction: Histopathological classification and HPV genotyping
Clavero, Omar
Epiteli
Papil·lomavirus
Epithelium
Papillomaviruses
title_short Squamous intraepithelial lesions of the anal squamocolumnar junction: Histopathological classification and HPV genotyping
title_full Squamous intraepithelial lesions of the anal squamocolumnar junction: Histopathological classification and HPV genotyping
title_fullStr Squamous intraepithelial lesions of the anal squamocolumnar junction: Histopathological classification and HPV genotyping
title_full_unstemmed Squamous intraepithelial lesions of the anal squamocolumnar junction: Histopathological classification and HPV genotyping
title_sort Squamous intraepithelial lesions of the anal squamocolumnar junction: Histopathological classification and HPV genotyping
dc.creator.none.fl_str_mv Clavero, Omar
McCloskey, Jenny
Molina, Vicente Marco
Quirós, Beatriz
Bravo, Ignacio G.
Sanjosé Llongueras, Silvia de
Bosch José, Francesc Xavier, 1947-
Pimenoff, Ville Nikolai
author Clavero, Omar
author_facet Clavero, Omar
McCloskey, Jenny
Molina, Vicente Marco
Quirós, Beatriz
Bravo, Ignacio G.
Sanjosé Llongueras, Silvia de
Bosch José, Francesc Xavier, 1947-
Pimenoff, Ville Nikolai
author_role author
author2 McCloskey, Jenny
Molina, Vicente Marco
Quirós, Beatriz
Bravo, Ignacio G.
Sanjosé Llongueras, Silvia de
Bosch José, Francesc Xavier, 1947-
Pimenoff, Ville Nikolai
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Epiteli
Papil·lomavirus
Epithelium
Papillomaviruses
topic Epiteli
Papil·lomavirus
Epithelium
Papillomaviruses
description Background: Human papillomavirus (HPV)-related anal cancer lesions are often found adjacent to the squamocolumnar junction (SCJ). We have assessed the histopathology and associated HPV genotypes in anal SCJ lesions in surgically excised anal warts in HIV-negative and -positive patients. Methods: Histopathology identified 47 squamous intraepithelial lesions (SILs) adjacent to the SCJ amongst a total of 145 cases of clinically diagnosed anal condylomata. The anal SCJ lesions were further analyzed with p16, CK7 and p63 immunohistochemistry and HPV genotyping. Results: Sixteen (16/47) of the excised anal wart lesions contained HSIL; Three were HSIL and exclusively associated with oncogenic HPVs. A further thirteen (13/47) were mixed lesions. Of these eight were HSILs with LSIL and six were HSILs with papillary immature metaplasia (PIM); Ten of the mixed lesions were associated with one or more oncogenic HPVs, while three cases were exclusively associated with HPV6. Conclusions: Clinically diagnosed anal warts cannot be assumed to be limited to low-grade lesions as anal warts of the SCJ often show heterogeneous lesions, with coexistence of LSIL, PIM, and HSIL. Lesions showing PIM, however, may mimic HSIL, because they are hypercellular, but lack the nuclear atypia and conspicuous mitotic activity of HSIL; and are p16 negative.
publishDate 2017
dc.date.none.fl_str_mv 2017
2018
2018
2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/124388
url https://hdl.handle.net/2445/124388
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1016/j.pvr.2016.12.001
Papillomavirus Research, 2017, vol. 3, p. 11-17
https://doi.org/10.1016/j.pvr.2016.12.001
dc.rights.none.fl_str_mv cc by-nc-nd (c) Clavero et al., 2017
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by-nc-nd (c) Clavero et al., 2017
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 7 p.
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.811543

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