Stimuli-responsive graphene-based hydrogel driven by disruption of triazine hydrophobic interactions

The study reported here concerns the preparation of a novel graphene-diaminotriazine (G-DAT) nanocomposite hydrogel for application in the drug delivery field. The hybrid nature of this material is founded on two key elements: the presence of the DAT backbone induced the formation of hydrophobic reg...

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Detalles Bibliográficos
Autores: Leganés Bayón, Jorge, Sánchez-Migallón, Ana, Merino Guijarro, Sonia, Vázquez Fernández-Pacheco, Ester
Tipo de recurso: artículo
Fecha de publicación:2020
País:España
Institución:Universidad de Castilla-La Mancha
Repositorio:RUIdeRA. Repositorio Institucional de la UCLM
OAI Identifier:oai:ruidera.uclm.es:10578/24278
Acceso en línea:https://hdl.handle.net/10578/24278
Access Level:acceso abierto
Palabra clave:Graphene
Hydrogel
Stimuli-responsive
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spelling Stimuli-responsive graphene-based hydrogel driven by disruption of triazine hydrophobic interactionsLeganés Bayón, JorgeSánchez-Migallón, AnaMerino Guijarro, SoniaVázquez Fernández-Pacheco, EsterGrapheneHydrogelStimuli-responsiveThe study reported here concerns the preparation of a novel graphene-diaminotriazine (G-DAT) nanocomposite hydrogel for application in the drug delivery field. The hybrid nature of this material is founded on two key elements: the presence of the DAT backbone induced the formation of hydrophobic regions that allowed efficient loading of a series of drugs of increasing hydrophobicity (Metronidazole, Benzocaine, Ibuprofen, Naproxen and Imipramine), while simultaneously endowing swelling-induced pH-responsiveness to the hydrogel. Additionally, the incorporation of graphene was found to interfere with these hydrophobic domains through favourable non-covalent interactions, thus leading to the partial disruption of these aggregates. As a consequence, graphene facilitated and enhanced the release of model hydrophobic drug Imipramine in a synergistic manner with the pH trigger, and increased the swelling capacities and improved mechanical performance. This hybrid hydrogel can therefore be envisaged as a proof-of-concept system for the release of hydrophobic compounds in the field of drug delivery.The Royal Society of Chemistry202020202020info:eu-repo/semantics/articleapplication/pdfapplication/pdfhttps://hdl.handle.net/10578/24278reponame:RUIdeRA. Repositorio Institucional de la UCLMinstname:Universidad de Castilla-La ManchaInglésFlagship project GA785219 Graphene core 2,European FEDER UNCM15-CE-2839,CTQ2014-53600-R (Spanish Goverment)CTQ2017-88158-R (Spanish Goverment)SBPLY/17/180501/000204 (Castilla-La Mancha Goverment)BES2015-074218 Grant Spanish Govermentinfo:eu-repo/semantics/openAccessoai:ruidera.uclm.es:10578/242782026-05-27T07:36:41Z
dc.title.none.fl_str_mv Stimuli-responsive graphene-based hydrogel driven by disruption of triazine hydrophobic interactions
title Stimuli-responsive graphene-based hydrogel driven by disruption of triazine hydrophobic interactions
spellingShingle Stimuli-responsive graphene-based hydrogel driven by disruption of triazine hydrophobic interactions
Leganés Bayón, Jorge
Graphene
Hydrogel
Stimuli-responsive
title_short Stimuli-responsive graphene-based hydrogel driven by disruption of triazine hydrophobic interactions
title_full Stimuli-responsive graphene-based hydrogel driven by disruption of triazine hydrophobic interactions
title_fullStr Stimuli-responsive graphene-based hydrogel driven by disruption of triazine hydrophobic interactions
title_full_unstemmed Stimuli-responsive graphene-based hydrogel driven by disruption of triazine hydrophobic interactions
title_sort Stimuli-responsive graphene-based hydrogel driven by disruption of triazine hydrophobic interactions
dc.creator.none.fl_str_mv Leganés Bayón, Jorge
Sánchez-Migallón, Ana
Merino Guijarro, Sonia
Vázquez Fernández-Pacheco, Ester
author Leganés Bayón, Jorge
author_facet Leganés Bayón, Jorge
Sánchez-Migallón, Ana
Merino Guijarro, Sonia
Vázquez Fernández-Pacheco, Ester
author_role author
author2 Sánchez-Migallón, Ana
Merino Guijarro, Sonia
Vázquez Fernández-Pacheco, Ester
author2_role author
author
author
dc.subject.none.fl_str_mv Graphene
Hydrogel
Stimuli-responsive
topic Graphene
Hydrogel
Stimuli-responsive
description The study reported here concerns the preparation of a novel graphene-diaminotriazine (G-DAT) nanocomposite hydrogel for application in the drug delivery field. The hybrid nature of this material is founded on two key elements: the presence of the DAT backbone induced the formation of hydrophobic regions that allowed efficient loading of a series of drugs of increasing hydrophobicity (Metronidazole, Benzocaine, Ibuprofen, Naproxen and Imipramine), while simultaneously endowing swelling-induced pH-responsiveness to the hydrogel. Additionally, the incorporation of graphene was found to interfere with these hydrophobic domains through favourable non-covalent interactions, thus leading to the partial disruption of these aggregates. As a consequence, graphene facilitated and enhanced the release of model hydrophobic drug Imipramine in a synergistic manner with the pH trigger, and increased the swelling capacities and improved mechanical performance. This hybrid hydrogel can therefore be envisaged as a proof-of-concept system for the release of hydrophobic compounds in the field of drug delivery.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/10578/24278
url https://hdl.handle.net/10578/24278
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Flagship project GA785219 Graphene core 2,
European FEDER UNCM15-CE-2839,
CTQ2014-53600-R (Spanish Goverment)
CTQ2017-88158-R (Spanish Goverment)
SBPLY/17/180501/000204 (Castilla-La Mancha Goverment)
BES2015-074218 Grant Spanish Goverment
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv The Royal Society of Chemistry
publisher.none.fl_str_mv The Royal Society of Chemistry
dc.source.none.fl_str_mv reponame:RUIdeRA. Repositorio Institucional de la UCLM
instname:Universidad de Castilla-La Mancha
instname_str Universidad de Castilla-La Mancha
reponame_str RUIdeRA. Repositorio Institucional de la UCLM
collection RUIdeRA. Repositorio Institucional de la UCLM
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300724

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