Reduced folate carrier (RFC) as a predictive marker for response to pemetrexed in advanced non-small cell lung cancer (NSCLC)

RFC is the major transport system in mammalian cells for folate cofactors and antifolate therapeutics. The aim of this study was to assess the predictive value of RFC expression in patients receiving pemetrexed for afvanced NSCLC.

Detalles Bibliográficos
Autores: Sánchez-Lorenzo, M. L. (María Luisa)|||/items/fb6ea26e-f740-4675-9b3d-5ecc547cdd88, Álvarez-Fernández, C. (Carlos)|||/items/ab71dfd5-f036-41a4-a80c-e95965660fcf, Ruiz-Echeverría, L. (Lucrecia)|||/items/5bd4d1ea-2111-4230-bbd3-7f0c9c9b698d, Rodríguez-Rubi, D. (David)|||/items/960cff27-4f97-4cfe-96ee-a3b020e87ed7, Li-Torres, W. (Walter)|||/items/cb3c3af2-165d-4df0-84f2-db83f8fe2f54, Izquierdo-Manuel, M. (Marta)|||/items/746cb2d7-cfc0-4edb-811c-403927c70a1c, Berros, J. P. (José P.)|||/items/30423ba9-1339-4e45-8d8f-766f16915c8f, Luque-Cabal, M. (María)|||/items/81fa7121-866e-4e37-bae9-d7a9d5582fc1, Jiménez-Fonseca, P. (Paula)|||/items/b4a18f79-34f0-4736-8966-255e938b871a, Villanueva-Palicio, N. (Noemi)|||/items/5e8363c9-802b-439b-9a81-4b61679f1def, Esteban-Gutiérrez, E. (Emilio)|||/items/68439c85-8c1b-4c99-857a-5cf34f82da8c
Tipo de recurso: artículo
Fecha de publicación:2013
País:España
Institución:Universidad de Navarra
Repositorio:Dadun. Depósito Académico Digital de la Universidad de Navarra
Idioma:inglés
OAI Identifier:oai:dadun.unav.edu:10171/68885
Acceso en línea:https://hdl.handle.net/10171/68885
Access Level:acceso abierto
Palabra clave:Reduced folate carrier
Pemetrexed
Advanced non-small-cell lung cancer
Predictive marker
Descripción
Sumario:RFC is the major transport system in mammalian cells for folate cofactors and antifolate therapeutics. The aim of this study was to assess the predictive value of RFC expression in patients receiving pemetrexed for afvanced NSCLC.

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