Impact in Plasma Metabolome as Effect of Lifestyle Intervention for Weight-Loss Reveals Metabolic Benefits in Metabolically Healthy Obese Women

Little is known regarding metabolic benefits of weight loss (WL) on the metabolically healthy obese (MHO) patients. We aimed to examine the impact of a lifestyle weight loss (LWL) treatment on the plasma metabolomic profile in MHO individuals. Plasma samples from 57 MHO women allocated to an intensi...

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Autores: Almanza Aguilera, Enrique, Brunius, Carl, Bernal López, M. Rosa, Garcia Aloy, Mar, Madrid Gambín, Francisco Javier, Tinahones, Francisco J., Gómez Huelgas, Ricardo, Landberg, Rikard, Andrés Lacueva, Ma. Cristina
Formato: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2018
País:España
Recursos:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/168917
Acesso em linha:https://hdl.handle.net/2445/168917
Access Level:acceso abierto
Palavra-chave:Metabolòmica
Persones obeses
Dones
Dietes d'aprimament
Metabolomics
Overweight persons
Women
Reducing diests
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spelling Impact in Plasma Metabolome as Effect of Lifestyle Intervention for Weight-Loss Reveals Metabolic Benefits in Metabolically Healthy Obese WomenAlmanza Aguilera, EnriqueBrunius, CarlBernal López, M. RosaGarcia Aloy, MarMadrid Gambín, Francisco JavierTinahones, Francisco J.Gómez Huelgas, RicardoLandberg, RikardAndrés Lacueva, Ma. CristinaMetabolòmicaPersones obesesDonesDietes d'aprimamentMetabolomicsOverweight personsWomenReducing diestsLittle is known regarding metabolic benefits of weight loss (WL) on the metabolically healthy obese (MHO) patients. We aimed to examine the impact of a lifestyle weight loss (LWL) treatment on the plasma metabolomic profile in MHO individuals. Plasma samples from 57 MHO women allocated to an intensive LWL treatment group (TG, hypocaloric Mediterranean diet and regular physical activity, n = 30) or to a control group (CG, general recommendations of a healthy diet and physical activity, n = 27) were analyzed using an untargeted 1H NMR metabolomics approach at baseline, after 3 months (intervention), and 12 months (follow-up). The impact of the LWL intervention on plasma metabolome was statistically significant at 3 months but not at follow-up and included higher levels of formate and phosphocreatine and lower levels of LDL/VLDL (signals) and trimethylamine in the TG. These metabolites were also correlated with WL. Higher myo-inositol, methylguanidine, and 3-hydroxybutyrate, and lower proline, were also found in the TG; higher levels of hippurate and asparagine, and lower levels of 2-hydroxybutyrate and creatine, were associated with WL. The current findings suggest that an intensive LWL treatment, and the consequent WL, leads to an improved plasma metabolic profile in MHO women through its impact on energy, amino acid, lipoprotein, and microbial metabolism. Keywords: NMR; hypocaloric diet; metabolically healthy obesity; metabolomics; physical activity.American Chemical Society2018info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfhttps://hdl.handle.net/2445/168917Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésVersió postprint del document publicat a: https://doi.org/10.1021/acs.jproteome.8b00042Journal of Proteome Research, 2018, vol. 17, num. 8, p. 2600-2610https://doi.org/10.1021/acs.jproteome.8b00042(c) American Chemical Society , 2018info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1689172026-05-27T06:46:51Z
dc.title.none.fl_str_mv Impact in Plasma Metabolome as Effect of Lifestyle Intervention for Weight-Loss Reveals Metabolic Benefits in Metabolically Healthy Obese Women
title Impact in Plasma Metabolome as Effect of Lifestyle Intervention for Weight-Loss Reveals Metabolic Benefits in Metabolically Healthy Obese Women
spellingShingle Impact in Plasma Metabolome as Effect of Lifestyle Intervention for Weight-Loss Reveals Metabolic Benefits in Metabolically Healthy Obese Women
Almanza Aguilera, Enrique
Metabolòmica
Persones obeses
Dones
Dietes d'aprimament
Metabolomics
Overweight persons
Women
Reducing diests
title_short Impact in Plasma Metabolome as Effect of Lifestyle Intervention for Weight-Loss Reveals Metabolic Benefits in Metabolically Healthy Obese Women
title_full Impact in Plasma Metabolome as Effect of Lifestyle Intervention for Weight-Loss Reveals Metabolic Benefits in Metabolically Healthy Obese Women
title_fullStr Impact in Plasma Metabolome as Effect of Lifestyle Intervention for Weight-Loss Reveals Metabolic Benefits in Metabolically Healthy Obese Women
title_full_unstemmed Impact in Plasma Metabolome as Effect of Lifestyle Intervention for Weight-Loss Reveals Metabolic Benefits in Metabolically Healthy Obese Women
title_sort Impact in Plasma Metabolome as Effect of Lifestyle Intervention for Weight-Loss Reveals Metabolic Benefits in Metabolically Healthy Obese Women
dc.creator.none.fl_str_mv Almanza Aguilera, Enrique
Brunius, Carl
Bernal López, M. Rosa
Garcia Aloy, Mar
Madrid Gambín, Francisco Javier
Tinahones, Francisco J.
Gómez Huelgas, Ricardo
Landberg, Rikard
Andrés Lacueva, Ma. Cristina
author Almanza Aguilera, Enrique
author_facet Almanza Aguilera, Enrique
Brunius, Carl
Bernal López, M. Rosa
Garcia Aloy, Mar
Madrid Gambín, Francisco Javier
Tinahones, Francisco J.
Gómez Huelgas, Ricardo
Landberg, Rikard
Andrés Lacueva, Ma. Cristina
author_role author
author2 Brunius, Carl
Bernal López, M. Rosa
Garcia Aloy, Mar
Madrid Gambín, Francisco Javier
Tinahones, Francisco J.
Gómez Huelgas, Ricardo
Landberg, Rikard
Andrés Lacueva, Ma. Cristina
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Metabolòmica
Persones obeses
Dones
Dietes d'aprimament
Metabolomics
Overweight persons
Women
Reducing diests
topic Metabolòmica
Persones obeses
Dones
Dietes d'aprimament
Metabolomics
Overweight persons
Women
Reducing diests
description Little is known regarding metabolic benefits of weight loss (WL) on the metabolically healthy obese (MHO) patients. We aimed to examine the impact of a lifestyle weight loss (LWL) treatment on the plasma metabolomic profile in MHO individuals. Plasma samples from 57 MHO women allocated to an intensive LWL treatment group (TG, hypocaloric Mediterranean diet and regular physical activity, n = 30) or to a control group (CG, general recommendations of a healthy diet and physical activity, n = 27) were analyzed using an untargeted 1H NMR metabolomics approach at baseline, after 3 months (intervention), and 12 months (follow-up). The impact of the LWL intervention on plasma metabolome was statistically significant at 3 months but not at follow-up and included higher levels of formate and phosphocreatine and lower levels of LDL/VLDL (signals) and trimethylamine in the TG. These metabolites were also correlated with WL. Higher myo-inositol, methylguanidine, and 3-hydroxybutyrate, and lower proline, were also found in the TG; higher levels of hippurate and asparagine, and lower levels of 2-hydroxybutyrate and creatine, were associated with WL. The current findings suggest that an intensive LWL treatment, and the consequent WL, leads to an improved plasma metabolic profile in MHO women through its impact on energy, amino acid, lipoprotein, and microbial metabolism. Keywords: NMR; hypocaloric diet; metabolically healthy obesity; metabolomics; physical activity.
publishDate 2018
dc.date.none.fl_str_mv 2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/168917
url https://hdl.handle.net/2445/168917
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Versió postprint del document publicat a: https://doi.org/10.1021/acs.jproteome.8b00042
Journal of Proteome Research, 2018, vol. 17, num. 8, p. 2600-2610
https://doi.org/10.1021/acs.jproteome.8b00042
dc.rights.none.fl_str_mv (c) American Chemical Society , 2018
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) American Chemical Society , 2018
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv American Chemical Society
publisher.none.fl_str_mv American Chemical Society
dc.source.none.fl_str_mv Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869421783119036416
score 15.301603

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