Identifying new blood biomarkers of neuroplasticity associated with rehabilitation outcomes after stroke

Blood biomarkers in stroke patients seek to guide decision-making in clinical practice, but research on those that respond to brain recovery and their relationship with rehabilitation is still limited. Our aim was to explore the value of known neuroplasticity-related molecules, such as endostatin, g...

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Autores: Garcia-Rodriguez, N, Garcia-Gabilondo, M, Rodriguez, S, Tejada, PI, Miranda-Artieda, ZM, Ridao, N, Buxó, X, Pérez-Mesquida, ME, Beseler, MR, Salom, JB, Pérez, LM, Inzitari, M, Otero-Villaverde, S, Martin-Mourelle, R, Molleda, M, Valor-Blanquer, J, Lamana-Vallverdú, M, Delgado, P, Penalba, A, Rosell, A
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
Repositorio:r-FISABIO. Repositorio Institucional de Producción Científica
OAI Identifier:oai:fisabio.fundanetsuite.com:p19854
Acceso en línea:https://fisabio.portalinvestigacion.com/publicaciones/19854
Access Level:acceso abierto
Palabra clave:Stroke
Biomarker
Neuroplasticity
Rehabilitation
Recovery
Repair
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spelling Identifying new blood biomarkers of neuroplasticity associated with rehabilitation outcomes after strokeGarcia-Rodriguez, NGarcia-Gabilondo, MRodriguez, STejada, PIMiranda-Artieda, ZMRidao, NBuxó, XPérez-Mesquida, MEBeseler, MRSalom, JBPérez, LMInzitari, MOtero-Villaverde, SMartin-Mourelle, RMolleda, MValor-Blanquer, JLamana-Vallverdú, MDelgado, PPenalba, ARosell, AStrokeBiomarkerNeuroplasticityRehabilitationRecoveryRepairBlood biomarkers in stroke patients seek to guide decision-making in clinical practice, but research on those that respond to brain recovery and their relationship with rehabilitation is still limited. Our aim was to explore the value of known neuroplasticity-related molecules, such as endostatin, growth and differentiation factor-10 (GDF-10), urokinase-type plasminogen activator (uPA) and the uPA receptor (uPAR), as blood biomarkers of recovery during poststroke rehabilitation. In an observational, prospective and multicenter study, biomarker levels were assessed after stroke in a cohort of 62 stroke patients with outcome evaluations and blood sampling before starting rehabilitation and during therapy at 1, 3 and 6 months of first visit, and in 43 control subjects. Serum levels were determined by Enzyme-Linked Immunosorbent Assay (ELISA) together with a complete battery of sensorimotor and functional tests/scales: modified Rankin Scale (mRS), Barthel Index (BI), Fugl-Meyer Assessment (FMA) for the upper extremity, Functional Ambulation Categories (FAC), Chedoke Arm and Hand Activity Inventory (CAHAI), 10-m walk test and the Medical Research Council (MRC). Statistical mixed linear models were built to investigate its prognostic value. The results revealed that, compared to controls, only endostatin was significantly increased at baseline after stroke (p < 0.01). Interestingly, the highest baseline GDF-10 or uPAR values were related to unfavorable scores during the complete follow-up (p < 0.05 for walking speed or MRC with GDF-10, and for FMA or MRC with uPAR), whereas decreased endostatin or increased GDF-10 biomarker changes at first month of rehabilitation were related to greater sensorimotor and functional improvements during follow-up (p < 0.05 for FMA or MRC with endostatin, and CAHAI or BI with GDF-10). Our results position endostatin, GDF-10 and uPAR as potential blood biomarkers to monitor recovery during rehabilitation after stroke.NATURE PORTFOLIO2025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fisabio.portalinvestigacion.com/publicaciones/19854Scientific ReportsISSN: 20452322reponame:r-FISABIO. Repositorio Institucional de Producción Científicainstname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)Inglésinfo:eu-repo/semantics/openAccessoai:fisabio.fundanetsuite.com:p198542026-06-11T12:45:17Z
dc.title.none.fl_str_mv Identifying new blood biomarkers of neuroplasticity associated with rehabilitation outcomes after stroke
title Identifying new blood biomarkers of neuroplasticity associated with rehabilitation outcomes after stroke
spellingShingle Identifying new blood biomarkers of neuroplasticity associated with rehabilitation outcomes after stroke
Garcia-Rodriguez, N
Stroke
Biomarker
Neuroplasticity
Rehabilitation
Recovery
Repair
title_short Identifying new blood biomarkers of neuroplasticity associated with rehabilitation outcomes after stroke
title_full Identifying new blood biomarkers of neuroplasticity associated with rehabilitation outcomes after stroke
title_fullStr Identifying new blood biomarkers of neuroplasticity associated with rehabilitation outcomes after stroke
title_full_unstemmed Identifying new blood biomarkers of neuroplasticity associated with rehabilitation outcomes after stroke
title_sort Identifying new blood biomarkers of neuroplasticity associated with rehabilitation outcomes after stroke
dc.creator.none.fl_str_mv Garcia-Rodriguez, N
Garcia-Gabilondo, M
Rodriguez, S
Tejada, PI
Miranda-Artieda, ZM
Ridao, N
Buxó, X
Pérez-Mesquida, ME
Beseler, MR
Salom, JB
Pérez, LM
Inzitari, M
Otero-Villaverde, S
Martin-Mourelle, R
Molleda, M
Valor-Blanquer, J
Lamana-Vallverdú, M
Delgado, P
Penalba, A
Rosell, A
author Garcia-Rodriguez, N
author_facet Garcia-Rodriguez, N
Garcia-Gabilondo, M
Rodriguez, S
Tejada, PI
Miranda-Artieda, ZM
Ridao, N
Buxó, X
Pérez-Mesquida, ME
Beseler, MR
Salom, JB
Pérez, LM
Inzitari, M
Otero-Villaverde, S
Martin-Mourelle, R
Molleda, M
Valor-Blanquer, J
Lamana-Vallverdú, M
Delgado, P
Penalba, A
Rosell, A
author_role author
author2 Garcia-Gabilondo, M
Rodriguez, S
Tejada, PI
Miranda-Artieda, ZM
Ridao, N
Buxó, X
Pérez-Mesquida, ME
Beseler, MR
Salom, JB
Pérez, LM
Inzitari, M
Otero-Villaverde, S
Martin-Mourelle, R
Molleda, M
Valor-Blanquer, J
Lamana-Vallverdú, M
Delgado, P
Penalba, A
Rosell, A
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Stroke
Biomarker
Neuroplasticity
Rehabilitation
Recovery
Repair
topic Stroke
Biomarker
Neuroplasticity
Rehabilitation
Recovery
Repair
description Blood biomarkers in stroke patients seek to guide decision-making in clinical practice, but research on those that respond to brain recovery and their relationship with rehabilitation is still limited. Our aim was to explore the value of known neuroplasticity-related molecules, such as endostatin, growth and differentiation factor-10 (GDF-10), urokinase-type plasminogen activator (uPA) and the uPA receptor (uPAR), as blood biomarkers of recovery during poststroke rehabilitation. In an observational, prospective and multicenter study, biomarker levels were assessed after stroke in a cohort of 62 stroke patients with outcome evaluations and blood sampling before starting rehabilitation and during therapy at 1, 3 and 6 months of first visit, and in 43 control subjects. Serum levels were determined by Enzyme-Linked Immunosorbent Assay (ELISA) together with a complete battery of sensorimotor and functional tests/scales: modified Rankin Scale (mRS), Barthel Index (BI), Fugl-Meyer Assessment (FMA) for the upper extremity, Functional Ambulation Categories (FAC), Chedoke Arm and Hand Activity Inventory (CAHAI), 10-m walk test and the Medical Research Council (MRC). Statistical mixed linear models were built to investigate its prognostic value. The results revealed that, compared to controls, only endostatin was significantly increased at baseline after stroke (p < 0.01). Interestingly, the highest baseline GDF-10 or uPAR values were related to unfavorable scores during the complete follow-up (p < 0.05 for walking speed or MRC with GDF-10, and for FMA or MRC with uPAR), whereas decreased endostatin or increased GDF-10 biomarker changes at first month of rehabilitation were related to greater sensorimotor and functional improvements during follow-up (p < 0.05 for FMA or MRC with endostatin, and CAHAI or BI with GDF-10). Our results position endostatin, GDF-10 and uPAR as potential blood biomarkers to monitor recovery during rehabilitation after stroke.
publishDate 2025
dc.date.none.fl_str_mv 2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://fisabio.portalinvestigacion.com/publicaciones/19854
url https://fisabio.portalinvestigacion.com/publicaciones/19854
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv NATURE PORTFOLIO
publisher.none.fl_str_mv NATURE PORTFOLIO
dc.source.none.fl_str_mv Scientific Reports
ISSN: 20452322
reponame:r-FISABIO. Repositorio Institucional de Producción Científica
instname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
instname_str Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
reponame_str r-FISABIO. Repositorio Institucional de Producción Científica
collection r-FISABIO. Repositorio Institucional de Producción Científica
repository.name.fl_str_mv
repository.mail.fl_str_mv
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