Dental plaque treatment via C16G2 Chitosan nanoparticle
Oral biofilm often represents a source of opportunistic pathogens that can cause, not only oral infections, but also systemic ones and different diseases. The conventional treatment of dental plaque and the excessive use of antibiotics have rendered these techniques obsolete. In this context, S. mut...
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| Tipo de recurso: | tesis de maestría |
| Fecha de publicación: | 2024 |
| País: | España |
| Institución: | Universitat Autònoma de Barcelona |
| Repositorio: | Dipòsit Digital de Documents de la UAB |
| Idioma: | inglés |
| OAI Identifier: | oai:ddd.uab.cat:301182 |
| Acceso en línea: | https://ddd.uab.cat/record/301182 |
| Access Level: | acceso abierto |
| Palabra clave: | Antimicrobial activity Dental plaque Chitosan nanoparticle C16G2 peptide Activitat antimicrobiana Placa dental Nanoparticules de quitosan Pèptid C16G2 |
| Sumario: | Oral biofilm often represents a source of opportunistic pathogens that can cause, not only oral infections, but also systemic ones and different diseases. The conventional treatment of dental plaque and the excessive use of antibiotics have rendered these techniques obsolete. In this context, S. mutans is identified as one of the principal initiators and stabilizers of oral biofilm. It has been suggested as one of the main targets for dental plaque elimination. Recent findings, indicate and describe a synthetic molecule called C16G2, which has a specific antimicrobial effect against S. mutans. This research proposal describes the construction of C16G2 chitosan nanoparticles which have antimicrobial activity and act as a drug delivery system. Additionally, it presents the recombinant expression of C16G2 antimicrobial molecule in E. coli to reduce costs and facilitate the industrial scale-up of the biotherapeutic. To achieve the highest effectiveness and yields, nanoparticle characterization, alongside with different antimicrobial assays, is also described in this work. |
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