Early Diversification of Membrane Intrinsic Proteins (MIPs) in Eukaryotes

Membrane intrinsic proteins (MIPs), including aquaporins (AQPs) and aquaglyceroporins (GLPs), form an ancient family of transporters for water and small solutes across biological membranes. The evolutionary history and functions of MIPs have been extensively studied in vertebrates and land plants, b...

ver descrição completa

Detalhes bibliográficos
Autores: Irisarri, Iker, Lorente Martínez, Héctor, Strassert, Jürgen F.H., Agorreta, Ainhoa, Zardoya, Rafael, San Mauro Martín, Diego, de Vries, Jan
Formato: artículo
Fecha de publicación:2024
País:España
Recursos:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/117608
Acesso em linha:https://hdl.handle.net/20.500.14352/117608
Access Level:acceso abierto
Palavra-chave:576
577.112
611.081.1
612.398
Aquaporin
Deep eukaryote evolution
Aquaglyceroporin
Last eukaryotic common ancestor
Water transport
Biología celular (Biología)
2407 Biología Celular
id ES_dc6eb86c962c640dfcadffda3d8788ff
oai_identifier_str oai:docta.ucm.es:20.500.14352/117608
network_acronym_str ES
network_name_str España
repository_id_str
spelling Early Diversification of Membrane Intrinsic Proteins (MIPs) in EukaryotesIrisarri, IkerLorente Martínez, HéctorStrassert, Jürgen F.H.Agorreta, AinhoaZardoya, RafaelSan Mauro Martín, Diegode Vries, Jan576577.112611.081.1612.398AquaporinDeep eukaryote evolutionAquaglyceroporinLast eukaryotic common ancestorWater transportBiología celular (Biología)2407 Biología CelularMembrane intrinsic proteins (MIPs), including aquaporins (AQPs) and aquaglyceroporins (GLPs), form an ancient family of transporters for water and small solutes across biological membranes. The evolutionary history and functions of MIPs have been extensively studied in vertebrates and land plants, but their widespread presence across the eukaryotic tree of life suggests both a more complex evolutionary history and a broader set of functions than previously thought. That said, the early evolution of MIPs remains obscure. The presence of one GLP and four AQP clades across both bacteria and archaea suggests that the first eukaryotes could have possessed up to five MIPs. Here, we report on a previously unknown richness in MIP diversity across all major eukaryotic lineages, including unicellular eukaryotes, which make up the bulk of eukaryotic diversity. Three MIP clades have likely deep evolutionary origins, dating back to the last eukaryotic common ancestor (LECA), and support the presence of a complex MIP repertoire in early eukaryotes. Overall, our findings highlight the growing complexity of the reconstructed LECA genome: the dynamic evolutionary history of MIPs was set in motion when eukaryotes were in their infancy followed by radiative bursts across all main eukaryotic lineages.Oxford University PressUniversidad Complutense de Madrid20242024-01-0120242024-01-01journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/117608reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/1176082026-06-02T12:44:21Z
dc.title.none.fl_str_mv Early Diversification of Membrane Intrinsic Proteins (MIPs) in Eukaryotes
title Early Diversification of Membrane Intrinsic Proteins (MIPs) in Eukaryotes
spellingShingle Early Diversification of Membrane Intrinsic Proteins (MIPs) in Eukaryotes
Irisarri, Iker
576
577.112
611.081.1
612.398
Aquaporin
Deep eukaryote evolution
Aquaglyceroporin
Last eukaryotic common ancestor
Water transport
Biología celular (Biología)
2407 Biología Celular
title_short Early Diversification of Membrane Intrinsic Proteins (MIPs) in Eukaryotes
title_full Early Diversification of Membrane Intrinsic Proteins (MIPs) in Eukaryotes
title_fullStr Early Diversification of Membrane Intrinsic Proteins (MIPs) in Eukaryotes
title_full_unstemmed Early Diversification of Membrane Intrinsic Proteins (MIPs) in Eukaryotes
title_sort Early Diversification of Membrane Intrinsic Proteins (MIPs) in Eukaryotes
dc.creator.none.fl_str_mv Irisarri, Iker
Lorente Martínez, Héctor
Strassert, Jürgen F.H.
Agorreta, Ainhoa
Zardoya, Rafael
San Mauro Martín, Diego
de Vries, Jan
author Irisarri, Iker
author_facet Irisarri, Iker
Lorente Martínez, Héctor
Strassert, Jürgen F.H.
Agorreta, Ainhoa
Zardoya, Rafael
San Mauro Martín, Diego
de Vries, Jan
author_role author
author2 Lorente Martínez, Héctor
Strassert, Jürgen F.H.
Agorreta, Ainhoa
Zardoya, Rafael
San Mauro Martín, Diego
de Vries, Jan
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 576
577.112
611.081.1
612.398
Aquaporin
Deep eukaryote evolution
Aquaglyceroporin
Last eukaryotic common ancestor
Water transport
Biología celular (Biología)
2407 Biología Celular
topic 576
577.112
611.081.1
612.398
Aquaporin
Deep eukaryote evolution
Aquaglyceroporin
Last eukaryotic common ancestor
Water transport
Biología celular (Biología)
2407 Biología Celular
description Membrane intrinsic proteins (MIPs), including aquaporins (AQPs) and aquaglyceroporins (GLPs), form an ancient family of transporters for water and small solutes across biological membranes. The evolutionary history and functions of MIPs have been extensively studied in vertebrates and land plants, but their widespread presence across the eukaryotic tree of life suggests both a more complex evolutionary history and a broader set of functions than previously thought. That said, the early evolution of MIPs remains obscure. The presence of one GLP and four AQP clades across both bacteria and archaea suggests that the first eukaryotes could have possessed up to five MIPs. Here, we report on a previously unknown richness in MIP diversity across all major eukaryotic lineages, including unicellular eukaryotes, which make up the bulk of eukaryotic diversity. Three MIP clades have likely deep evolutionary origins, dating back to the last eukaryotic common ancestor (LECA), and support the presence of a complex MIP repertoire in early eukaryotes. Overall, our findings highlight the growing complexity of the reconstructed LECA genome: the dynamic evolutionary history of MIPs was set in motion when eukaryotes were in their infancy followed by radiative bursts across all main eukaryotic lineages.
publishDate 2024
dc.date.none.fl_str_mv 2024
2024-01-01
2024
2024-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/117608
url https://hdl.handle.net/20.500.14352/117608
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869421768587870208
score 15,812429

Registos relacionados