Toenails as a biomarker of exposure to arsenic: A review.
This systematic review summarizes the current evidence related to the reliability of toenail total arsenic concentrations (thereafter "arsenic") as a biomarker of long-term exposure. Specifically, we reviewed literature on consistency of repeated measures over time, association with other...
| Autores: | , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2021 |
| País: | España |
| Institución: | Instituto de Salud Carlos III (ISCIII) |
| Repositorio: | Repisalud |
| Idioma: | inglés |
| OAI Identifier: | oai:repisalud.isciii.es:20.500.12105/27187 |
| Acceso en línea: | https://hdl.handle.net/20.500.12105/27187 |
| Access Level: | acceso abierto |
| Palabra clave: | Arsenic Biomarker Biomonitoring Exposure Toenail |
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Toenails as a biomarker of exposure to arsenic: A review.Signes-Pastor, Antonio JGutiérrez-González, EnriqueGarcía-Villarino, MiguelRodriguez-Cabrera, Francisco DavidLópez-Moreno, Jorge JVarea-Jiménez, ElenaPastor-Barriuso, RobertoPollan-Santamaria, MarinaNavas-Acien, AnaPerez-Gomez, BeatrizKaragas, Margaret RArsenicBiomarkerBiomonitoringExposureToenailThis systematic review summarizes the current evidence related to the reliability of toenail total arsenic concentrations (thereafter "arsenic") as a biomarker of long-term exposure. Specifically, we reviewed literature on consistency of repeated measures over time, association with other biomarkers and metal concentrations, factors influencing concentrations, and associations with health effects. We identified 129 papers containing quantitative original data on arsenic in toenail samples covering populations from 29 different countries. We observed geographic differences in toenail arsenic concentrations, with highest median or mean concentrations in Asian countries. Arsenic-contaminated drinking water, occupational exposure or living in specific industrial areas were associated with an increased toenail arsenic content. The effects of other potential determinants and sources of arsenic exposure including diet, gender and age on the concentrations in toenails need further investigations. Toenail arsenic was correlated with the concentrations in hair and fingernails, and with urine arsenic mainly among highly exposed populations with a toenail mean or median ≥1 μg/g. Overall, there is a growing body of evidence suggesting that arsenic content from a single toenail sample may reflect long-term internal dose-exposure. Toenail arsenic can serve as a reliable measure of toxic inorganic arsenic exposure in chronic disease research, particularly promising for cancer and cardiovascular conditions.Elsevier20262026-01-2820212021-04-0120212021-04-01review articlehttp://purl.org/coar/resource_type/c_dcae04bcAMhttp://purl.org/coar/version/c_ab4af688f83e57aainfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.12105/27187reponame:Repisaludinstname:Instituto de Salud Carlos III (ISCIII)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:repisalud.isciii.es:20.500.12105/271872026-06-12T12:43:37Z |
| dc.title.none.fl_str_mv |
Toenails as a biomarker of exposure to arsenic: A review. |
| title |
Toenails as a biomarker of exposure to arsenic: A review. |
| spellingShingle |
Toenails as a biomarker of exposure to arsenic: A review. Signes-Pastor, Antonio J Arsenic Biomarker Biomonitoring Exposure Toenail |
| title_short |
Toenails as a biomarker of exposure to arsenic: A review. |
| title_full |
Toenails as a biomarker of exposure to arsenic: A review. |
| title_fullStr |
Toenails as a biomarker of exposure to arsenic: A review. |
| title_full_unstemmed |
Toenails as a biomarker of exposure to arsenic: A review. |
| title_sort |
Toenails as a biomarker of exposure to arsenic: A review. |
| dc.creator.none.fl_str_mv |
Signes-Pastor, Antonio J Gutiérrez-González, Enrique García-Villarino, Miguel Rodriguez-Cabrera, Francisco David López-Moreno, Jorge J Varea-Jiménez, Elena Pastor-Barriuso, Roberto Pollan-Santamaria, Marina Navas-Acien, Ana Perez-Gomez, Beatriz Karagas, Margaret R |
| author |
Signes-Pastor, Antonio J |
| author_facet |
Signes-Pastor, Antonio J Gutiérrez-González, Enrique García-Villarino, Miguel Rodriguez-Cabrera, Francisco David López-Moreno, Jorge J Varea-Jiménez, Elena Pastor-Barriuso, Roberto Pollan-Santamaria, Marina Navas-Acien, Ana Perez-Gomez, Beatriz Karagas, Margaret R |
| author_role |
author |
| author2 |
Gutiérrez-González, Enrique García-Villarino, Miguel Rodriguez-Cabrera, Francisco David López-Moreno, Jorge J Varea-Jiménez, Elena Pastor-Barriuso, Roberto Pollan-Santamaria, Marina Navas-Acien, Ana Perez-Gomez, Beatriz Karagas, Margaret R |
| author2_role |
author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
|
| dc.subject.none.fl_str_mv |
Arsenic Biomarker Biomonitoring Exposure Toenail |
| topic |
Arsenic Biomarker Biomonitoring Exposure Toenail |
| description |
This systematic review summarizes the current evidence related to the reliability of toenail total arsenic concentrations (thereafter "arsenic") as a biomarker of long-term exposure. Specifically, we reviewed literature on consistency of repeated measures over time, association with other biomarkers and metal concentrations, factors influencing concentrations, and associations with health effects. We identified 129 papers containing quantitative original data on arsenic in toenail samples covering populations from 29 different countries. We observed geographic differences in toenail arsenic concentrations, with highest median or mean concentrations in Asian countries. Arsenic-contaminated drinking water, occupational exposure or living in specific industrial areas were associated with an increased toenail arsenic content. The effects of other potential determinants and sources of arsenic exposure including diet, gender and age on the concentrations in toenails need further investigations. Toenail arsenic was correlated with the concentrations in hair and fingernails, and with urine arsenic mainly among highly exposed populations with a toenail mean or median ≥1 μg/g. Overall, there is a growing body of evidence suggesting that arsenic content from a single toenail sample may reflect long-term internal dose-exposure. Toenail arsenic can serve as a reliable measure of toxic inorganic arsenic exposure in chronic disease research, particularly promising for cancer and cardiovascular conditions. |
| publishDate |
2021 |
| dc.date.none.fl_str_mv |
2021 2021-04-01 2021 2021-04-01 2026 2026-01-28 |
| dc.type.none.fl_str_mv |
review article http://purl.org/coar/resource_type/c_dcae04bc AM http://purl.org/coar/version/c_ab4af688f83e57aa |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/20.500.12105/27187 |
| url |
https://hdl.handle.net/20.500.12105/27187 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| dc.rights.openaire.fl_str_mv |
info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ |
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openAccess |
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application/pdf |
| dc.publisher.none.fl_str_mv |
Elsevier |
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Elsevier |
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reponame:Repisalud instname:Instituto de Salud Carlos III (ISCIII) |
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Instituto de Salud Carlos III (ISCIII) |
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Repisalud |
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Repisalud |
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15,811543 |