Follow-Up Study Confirms the Presence of Gastric Cancer DNA Methylation Hallmarks in High-Risk Precursor Lesions.

To adopt prevention strategies in gastric cancer, it is imperative to develop robust biomarkers with acceptable costs and feasibility in clinical practice to stratified populations according to risk scores. With this aim, we applied an unbiased genome-wide CpG methylation approach to a discovery coh...

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Autores: Gómez A, Pato ML, Bujanda L, Sala N, Companioni O, Cosme Á, Tufano M, Hanly DJ, García N, Sanz-Anquela JM, Gisbert JP, López C, Elizalde JI, Cuatrecasas M, Andreu V, Paules MJ, Martín-Arranz MD, Ortega L, Poves E, Barrio J, Torres MÁ, Muñoz G, Ferrández Á, Ramírez-Lázaro MJ, Lario S, González CA, Esteller M, Berdasco M
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Institut d'Investigació i Innovació Parc Taulí (I3PT)
Repositorio:r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
OAI Identifier:oai:i3pt.fundanetsuite.com:p1718
Acceso en línea:https://i3pt.portalinvestigacion.com/publicaciones/1718
Access Level:acceso abierto
Palabra clave:CpG methylation, Helicobacter pylori, cancer risk prediction, intestinal type of gastric cancer, precursor lesions
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spelling Follow-Up Study Confirms the Presence of Gastric Cancer DNA Methylation Hallmarks in High-Risk Precursor Lesions.Gómez APato MLBujanda LSala NCompanioni OCosme ÁTufano MHanly DJGarcía NSanz-Anquela JMGisbert JPLópez CElizalde JICuatrecasas MAndreu VPaules MJMartín-Arranz MDOrtega LPoves EBarrio JTorres MÁMuñoz GFerrández ÁRamírez-Lázaro MJLario SGonzález CAEsteller MBerdasco MCpG methylation, Helicobacter pylori, cancer risk prediction, intestinal type of gastric cancer, precursor lesionsTo adopt prevention strategies in gastric cancer, it is imperative to develop robust biomarkers with acceptable costs and feasibility in clinical practice to stratified populations according to risk scores. With this aim, we applied an unbiased genome-wide CpG methylation approach to a discovery cohort composed of gastric cancer ( n = 24), and non-malignant precursor lesions ( n = 64). Then, candidate-methylation approaches were performed in a validation cohort of precursor lesions obtained from an observational longitudinal study ( n = 264), with a 12-year follow-up to identify repression or progression cases. H. pylori stratification and histology were considered to determine their influence on the methylation dynamics. As a result, we ascertained that intestinal metaplasia partially recapitulates patterns of aberrant methylation of intestinal type of gastric cancer, independently of the H. pylori status. Two epigenetically regulated genes in cancer, RPRM and ZNF793 , consistently showed increased methylation in intestinal metaplasia with respect to earlier precursor lesions. In summary, our result supports the need to investigate the practical utilities of the quantification of DNA methylation in candidate genes as a marker for disease progression. In addition, the H. pylori -dependent methylation in intestinal metaplasia suggests that pharmacological treatments aimed at H. pylori eradication in the late stages of precursor lesions do not prevent epigenome reprogramming toward a cancer signature.MDPI2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://i3pt.portalinvestigacion.com/publicaciones/1718CancersISSN: 20726694reponame:r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulíinstname:Institut d'Investigació i Innovació Parc Taulí (I3PT)Inglésinfo:eu-repo/semantics/openAccessoai:i3pt.fundanetsuite.com:p17182026-06-21T15:30:37Z
dc.title.none.fl_str_mv Follow-Up Study Confirms the Presence of Gastric Cancer DNA Methylation Hallmarks in High-Risk Precursor Lesions.
title Follow-Up Study Confirms the Presence of Gastric Cancer DNA Methylation Hallmarks in High-Risk Precursor Lesions.
spellingShingle Follow-Up Study Confirms the Presence of Gastric Cancer DNA Methylation Hallmarks in High-Risk Precursor Lesions.
Gómez A
CpG methylation, Helicobacter pylori, cancer risk prediction, intestinal type of gastric cancer, precursor lesions
title_short Follow-Up Study Confirms the Presence of Gastric Cancer DNA Methylation Hallmarks in High-Risk Precursor Lesions.
title_full Follow-Up Study Confirms the Presence of Gastric Cancer DNA Methylation Hallmarks in High-Risk Precursor Lesions.
title_fullStr Follow-Up Study Confirms the Presence of Gastric Cancer DNA Methylation Hallmarks in High-Risk Precursor Lesions.
title_full_unstemmed Follow-Up Study Confirms the Presence of Gastric Cancer DNA Methylation Hallmarks in High-Risk Precursor Lesions.
title_sort Follow-Up Study Confirms the Presence of Gastric Cancer DNA Methylation Hallmarks in High-Risk Precursor Lesions.
dc.creator.none.fl_str_mv Gómez A
Pato ML
Bujanda L
Sala N
Companioni O
Cosme Á
Tufano M
Hanly DJ
García N
Sanz-Anquela JM
Gisbert JP
López C
Elizalde JI
Cuatrecasas M
Andreu V
Paules MJ
Martín-Arranz MD
Ortega L
Poves E
Barrio J
Torres MÁ
Muñoz G
Ferrández Á
Ramírez-Lázaro MJ
Lario S
González CA
Esteller M
Berdasco M
author Gómez A
author_facet Gómez A
Pato ML
Bujanda L
Sala N
Companioni O
Cosme Á
Tufano M
Hanly DJ
García N
Sanz-Anquela JM
Gisbert JP
López C
Elizalde JI
Cuatrecasas M
Andreu V
Paules MJ
Martín-Arranz MD
Ortega L
Poves E
Barrio J
Torres MÁ
Muñoz G
Ferrández Á
Ramírez-Lázaro MJ
Lario S
González CA
Esteller M
Berdasco M
author_role author
author2 Pato ML
Bujanda L
Sala N
Companioni O
Cosme Á
Tufano M
Hanly DJ
García N
Sanz-Anquela JM
Gisbert JP
López C
Elizalde JI
Cuatrecasas M
Andreu V
Paules MJ
Martín-Arranz MD
Ortega L
Poves E
Barrio J
Torres MÁ
Muñoz G
Ferrández Á
Ramírez-Lázaro MJ
Lario S
González CA
Esteller M
Berdasco M
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv CpG methylation, Helicobacter pylori, cancer risk prediction, intestinal type of gastric cancer, precursor lesions
topic CpG methylation, Helicobacter pylori, cancer risk prediction, intestinal type of gastric cancer, precursor lesions
description To adopt prevention strategies in gastric cancer, it is imperative to develop robust biomarkers with acceptable costs and feasibility in clinical practice to stratified populations according to risk scores. With this aim, we applied an unbiased genome-wide CpG methylation approach to a discovery cohort composed of gastric cancer ( n = 24), and non-malignant precursor lesions ( n = 64). Then, candidate-methylation approaches were performed in a validation cohort of precursor lesions obtained from an observational longitudinal study ( n = 264), with a 12-year follow-up to identify repression or progression cases. H. pylori stratification and histology were considered to determine their influence on the methylation dynamics. As a result, we ascertained that intestinal metaplasia partially recapitulates patterns of aberrant methylation of intestinal type of gastric cancer, independently of the H. pylori status. Two epigenetically regulated genes in cancer, RPRM and ZNF793 , consistently showed increased methylation in intestinal metaplasia with respect to earlier precursor lesions. In summary, our result supports the need to investigate the practical utilities of the quantification of DNA methylation in candidate genes as a marker for disease progression. In addition, the H. pylori -dependent methylation in intestinal metaplasia suggests that pharmacological treatments aimed at H. pylori eradication in the late stages of precursor lesions do not prevent epigenome reprogramming toward a cancer signature.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://i3pt.portalinvestigacion.com/publicaciones/1718
url https://i3pt.portalinvestigacion.com/publicaciones/1718
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Cancers
ISSN: 20726694
reponame:r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
instname:Institut d'Investigació i Innovació Parc Taulí (I3PT)
instname_str Institut d'Investigació i Innovació Parc Taulí (I3PT)
reponame_str r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
collection r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
repository.name.fl_str_mv
repository.mail.fl_str_mv
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