Mortality in patients with giant cell arteritis in Spain: results from the ARTESER registry

Objectives: To compare mortality rates between GCA patients and the general population in Spain, and to identify associated factors influencing mortality. Methods: ARTESER, a multicenter registry by the Spanish Society of Rheumatology, includes GCA patients from June 2013 to March 2019. Demographic,...

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Autores: Molina-Collada, Juan, Labrada Arrabal, Selena, ARTESER Project Collaborative Group
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Universitat Pompeu Fabra
Repositorio:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/71537
Acceso en línea:http://hdl.handle.net/10230/71537
http://dx.doi.org/10.1186/s13075-024-03468-6
Access Level:acceso abierto
Palabra clave:Giant cell arteritis
Mortality
Survival
Vasculitis
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spelling Mortality in patients with giant cell arteritis in Spain: results from the ARTESER registryMolina-Collada, JuanLabrada Arrabal, SelenaARTESER Project Collaborative GroupGiant cell arteritisMortalitySurvivalVasculitisObjectives: To compare mortality rates between GCA patients and the general population in Spain, and to identify associated factors influencing mortality. Methods: ARTESER, a multicenter registry by the Spanish Society of Rheumatology, includes GCA patients from June 2013 to March 2019. Demographic, clinical, imaging, histological and mortality data were collected retrospectively. Only patients with at least one year of follow-up were included for analysis. The mortality rates were expressed as the number of deaths per 1000 person-years, with 95% confidence interval (CI) by sex and age group. Kaplan-Meier method was performed for survival analysis. The factors influencing mortality were analyzed using Cox regression model. Results: A total of 1200 patients with GCA were analyzed, with a mean (SD) follow-up of 2.18 (1.53) years. The overall five-year cumulative mortality rate (95%CI) was 37.86 (31.75-43.96) per 1000 patients/year. The cumulative mortality rate was significantly higher in males than females (59.04vs29.06; p<0.001). The age- and sex-adjusted cumulative mortality rate was similar to the Spanish general population (19.75vs20.72;p=0.559). In the multivariate analysis, older age (HR 1.11, 95%CI 1.073-1.142) and male sex (HR 1.775, 95%CI 1.214-2.594) were associated with increased mortality. Headache (HR 0.55, 95%CI 0.362-0.843) and high hemoglobin levels (HR 0.85, 95%CI 0.744-0.970) were protective factors against death. Conclusions: The overall five-year age- and sex-adjusted cumulative mortality rate in GCA is similar compared to the general population. Older age and male sex appear to be associated with an increased risk of mortality, whereas headache and high hemoglobin levels might serve as protective factors against death.BioMed Central2025202520252025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/71537http://dx.doi.org/10.1186/s13075-024-03468-6reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésArthritis research & therapy. 2025;27(1):4© The Author(s) 2025. Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article¿s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article¿s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/715372026-06-12T07:21:37Z
dc.title.none.fl_str_mv Mortality in patients with giant cell arteritis in Spain: results from the ARTESER registry
title Mortality in patients with giant cell arteritis in Spain: results from the ARTESER registry
spellingShingle Mortality in patients with giant cell arteritis in Spain: results from the ARTESER registry
Molina-Collada, Juan
Giant cell arteritis
Mortality
Survival
Vasculitis
title_short Mortality in patients with giant cell arteritis in Spain: results from the ARTESER registry
title_full Mortality in patients with giant cell arteritis in Spain: results from the ARTESER registry
title_fullStr Mortality in patients with giant cell arteritis in Spain: results from the ARTESER registry
title_full_unstemmed Mortality in patients with giant cell arteritis in Spain: results from the ARTESER registry
title_sort Mortality in patients with giant cell arteritis in Spain: results from the ARTESER registry
dc.creator.none.fl_str_mv Molina-Collada, Juan
Labrada Arrabal, Selena
ARTESER Project Collaborative Group
author Molina-Collada, Juan
author_facet Molina-Collada, Juan
Labrada Arrabal, Selena
ARTESER Project Collaborative Group
author_role author
author2 Labrada Arrabal, Selena
ARTESER Project Collaborative Group
author2_role author
author
dc.subject.none.fl_str_mv Giant cell arteritis
Mortality
Survival
Vasculitis
topic Giant cell arteritis
Mortality
Survival
Vasculitis
description Objectives: To compare mortality rates between GCA patients and the general population in Spain, and to identify associated factors influencing mortality. Methods: ARTESER, a multicenter registry by the Spanish Society of Rheumatology, includes GCA patients from June 2013 to March 2019. Demographic, clinical, imaging, histological and mortality data were collected retrospectively. Only patients with at least one year of follow-up were included for analysis. The mortality rates were expressed as the number of deaths per 1000 person-years, with 95% confidence interval (CI) by sex and age group. Kaplan-Meier method was performed for survival analysis. The factors influencing mortality were analyzed using Cox regression model. Results: A total of 1200 patients with GCA were analyzed, with a mean (SD) follow-up of 2.18 (1.53) years. The overall five-year cumulative mortality rate (95%CI) was 37.86 (31.75-43.96) per 1000 patients/year. The cumulative mortality rate was significantly higher in males than females (59.04vs29.06; p<0.001). The age- and sex-adjusted cumulative mortality rate was similar to the Spanish general population (19.75vs20.72;p=0.559). In the multivariate analysis, older age (HR 1.11, 95%CI 1.073-1.142) and male sex (HR 1.775, 95%CI 1.214-2.594) were associated with increased mortality. Headache (HR 0.55, 95%CI 0.362-0.843) and high hemoglobin levels (HR 0.85, 95%CI 0.744-0.970) were protective factors against death. Conclusions: The overall five-year age- and sex-adjusted cumulative mortality rate in GCA is similar compared to the general population. Older age and male sex appear to be associated with an increased risk of mortality, whereas headache and high hemoglobin levels might serve as protective factors against death.
publishDate 2025
dc.date.none.fl_str_mv 2025
2025
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/71537
http://dx.doi.org/10.1186/s13075-024-03468-6
url http://hdl.handle.net/10230/71537
http://dx.doi.org/10.1186/s13075-024-03468-6
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Arthritis research & therapy. 2025;27(1):4
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
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eu_rights_str_mv openAccess
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dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv reponame:Repositorio Digital de la UPF
instname:Universitat Pompeu Fabra
instname_str Universitat Pompeu Fabra
reponame_str Repositorio Digital de la UPF
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