Harnessing landrace diversity empowers wheat breeding

Harnessing genetic diversity in major staple crops through the development of new breeding capabilities is essential to ensure food security1. Here we examined the genetic and phenotypic diversity of the A. E. Watkins landrace collection2 of bread wheat (Triticum aestivum), a major global cereal, by...

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Autores: Cheng, Shifeng, Feng, Cong, Wingen, Luzie U., Cheng, Hong, Riche, Andrew B., Jiang, Mei, Leverington-Waite, Michelle, Huang, Zejian, Collier, Sarah, Orford, Simon, Wang, Xiaoming, Awal, Rajani, Barker, Gary, O’Hara, Tom, Lister, Clare, Bicego, Breno
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10459.1/466820
Acceso en línea:https://doi.org/10.1038/s41586-024-07682-9
https://hdl.handle.net/10459.1/466820
Access Level:acceso abierto
Palabra clave:Alleles
Crops, Agricultural
Genetic Introgression
Genetic Variation
Genome, Plant
id ES_dc3293d79656d45587fd4103bb2af3da
oai_identifier_str oai:recercat.cat:10459.1/466820
network_acronym_str ES
network_name_str España
repository_id_str
dc.title.none.fl_str_mv Harnessing landrace diversity empowers wheat breeding
title Harnessing landrace diversity empowers wheat breeding
spellingShingle Harnessing landrace diversity empowers wheat breeding
Cheng, Shifeng
Alleles
Crops, Agricultural
Genetic Introgression
Genetic Variation
Genome, Plant
title_short Harnessing landrace diversity empowers wheat breeding
title_full Harnessing landrace diversity empowers wheat breeding
title_fullStr Harnessing landrace diversity empowers wheat breeding
title_full_unstemmed Harnessing landrace diversity empowers wheat breeding
title_sort Harnessing landrace diversity empowers wheat breeding
dc.creator.none.fl_str_mv Cheng, Shifeng
Feng, Cong
Wingen, Luzie U.
Cheng, Hong
Riche, Andrew B.
Jiang, Mei
Leverington-Waite, Michelle
Huang, Zejian
Collier, Sarah
Orford, Simon
Wang, Xiaoming
Awal, Rajani
Barker, Gary
O’Hara, Tom
Lister, Clare
Bicego, Breno
author Cheng, Shifeng
author_facet Cheng, Shifeng
Feng, Cong
Wingen, Luzie U.
Cheng, Hong
Riche, Andrew B.
Jiang, Mei
Leverington-Waite, Michelle
Huang, Zejian
Collier, Sarah
Orford, Simon
Wang, Xiaoming
Awal, Rajani
Barker, Gary
O’Hara, Tom
Lister, Clare
Bicego, Breno
author_role author
author2 Feng, Cong
Wingen, Luzie U.
Cheng, Hong
Riche, Andrew B.
Jiang, Mei
Leverington-Waite, Michelle
Huang, Zejian
Collier, Sarah
Orford, Simon
Wang, Xiaoming
Awal, Rajani
Barker, Gary
O’Hara, Tom
Lister, Clare
Bicego, Breno
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Alleles
Crops, Agricultural
Genetic Introgression
Genetic Variation
Genome, Plant
topic Alleles
Crops, Agricultural
Genetic Introgression
Genetic Variation
Genome, Plant
description Harnessing genetic diversity in major staple crops through the development of new breeding capabilities is essential to ensure food security1. Here we examined the genetic and phenotypic diversity of the A. E. Watkins landrace collection2 of bread wheat (Triticum aestivum), a major global cereal, by whole-genome re-sequencing of 827 Watkins landraces and 208 modern cultivars and in-depth field evaluation spanning a decade. We found that modern cultivars are derived from two of the seven ancestral groups of wheat and maintain very long-range haplotype integrity. The remaining five groups represent untapped genetic sources, providing access to landrace-specific alleles and haplotypes for breeding. Linkage disequilibrium-based haplotypes and association genetics analyses link Watkins genomes to the thousands of identified high-resolution quantitative trait loci and significant marker–trait associations. Using these structured germplasm, genotyping and informatics resources, we revealed many Watkins-unique beneficial haplotypes that can confer superior traits in modern wheat. Furthermore, we assessed the phenotypic effects of 44,338 Watkins-unique haplotypes, introgressed from 143 prioritized quantitative trait loci in the context of modern cultivars, bridging the gap between landrace diversity and current breeding. This study establishes a framework for systematically utilizing genetic diversity in crop improvement to achieve sustainable food security.
publishDate 2024
dc.date.none.fl_str_mv 2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.1038/s41586-024-07682-9
https://hdl.handle.net/10459.1/466820
url https://doi.org/10.1038/s41586-024-07682-9
https://hdl.handle.net/10459.1/466820
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a https://doi.org/10.1038/s41586-024-07682-9
Nature, 2024, vol. 632, núm. 8026, p. 823-831
dc.rights.none.fl_str_mv cc by (c) Cheng et al., 2024
Attribution 4.0 International
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
rights_invalid_str_mv cc by (c) Cheng et al., 2024
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Nature Research
publisher.none.fl_str_mv Nature Research
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869421746419924992
spelling Harnessing landrace diversity empowers wheat breedingCheng, ShifengFeng, CongWingen, Luzie U.Cheng, HongRiche, Andrew B.Jiang, MeiLeverington-Waite, MichelleHuang, ZejianCollier, SarahOrford, SimonWang, XiaomingAwal, RajaniBarker, GaryO’Hara, TomLister, ClareBicego, BrenoAllelesCrops, AgriculturalGenetic IntrogressionGenetic VariationGenome, PlantHarnessing genetic diversity in major staple crops through the development of new breeding capabilities is essential to ensure food security1. Here we examined the genetic and phenotypic diversity of the A. E. Watkins landrace collection2 of bread wheat (Triticum aestivum), a major global cereal, by whole-genome re-sequencing of 827 Watkins landraces and 208 modern cultivars and in-depth field evaluation spanning a decade. We found that modern cultivars are derived from two of the seven ancestral groups of wheat and maintain very long-range haplotype integrity. The remaining five groups represent untapped genetic sources, providing access to landrace-specific alleles and haplotypes for breeding. Linkage disequilibrium-based haplotypes and association genetics analyses link Watkins genomes to the thousands of identified high-resolution quantitative trait loci and significant marker–trait associations. Using these structured germplasm, genotyping and informatics resources, we revealed many Watkins-unique beneficial haplotypes that can confer superior traits in modern wheat. Furthermore, we assessed the phenotypic effects of 44,338 Watkins-unique haplotypes, introgressed from 143 prioritized quantitative trait loci in the context of modern cultivars, bridging the gap between landrace diversity and current breeding. This study establishes a framework for systematically utilizing genetic diversity in crop improvement to achieve sustainable food security.The authors thank G. Moore and M. Bevan for providing valuable feedback at multiple stages of the project; colleagues for assistance in Watkins field trial and phenotyping work from five experimental stations across China: Z. Zhu, Q. Wang, Y. Song, Y. Zhu and X. Zhang; the John Innes Centre (JIC) NBI Computing Infrastructure for Science group; the JIC Field Trials and Horticultural Services teams for support in field and glasshouse experiments; T. Florio for figure visualization; and the Rothamsted Research farm team and Analytical Chemistry unit for support in field experiments and analytical mineral analyses. This work was supported by the Program for Guangdong \u201CZhuJiang\u201D Introducing Innovative and Entrepreneurial Teams (2019ZT08N628), the National Natural Science Foundation of China (32022006), the Agricultural Science and Technology Innovation Program (CAAS-ASTIP-2021-AGIS-ZDRW202101), the Shenzhen Science and Technology Program (AGIS-ZDKY202002) to S. Cheng, and the Guangdong Basic and Applied Basic Research Foundation (2020A1515110677) to L.M. The UK work was possible owing to the long-term investment of the UK Biotechnology and Biological Sciences Research Council (BBSRC) in wheat research through Institute Strategic Programme (ISP) grants and longer larger grants: BBSRC LOLA \u2018Enhancing diversity in UK wheat through a public sector prebreeding programme\u2019 (BB/I002545/1); BBSRC ISP \u2018JIC WISP ISP\u2014Wheat Institute Strategic Programme\u2019 (BB/J004596/1); BBSRC ISP \u2018BBSRC Strategic Programme in Designing Future Wheat (DFW)\u2019 (BB/P016855/1); BBSRC ISP \u2018BBSRC Institute Strategic Programme: Delivering Sustainable Wheat (DSW)\u2019 (BB/X011003/1) and for wheat germplasm conservation and global distribution through the Germplasm Resources BBSRC National Capability award (BBS/E/J/000PR8000). S.G. and C.L. also received support from the UK Department for Environment, Food and Rural Affairs (Defra) as part of WGIN phases 3 and 4 (CH0106 and CH0109). This work was also supported by the European Research Council (ERC-2019-COG-866328), the Sustainable Crop Production Research for International Development (SCPRID) programme (BB/J012017/1), the Mexican Consejo Nacional de Ciencia y Tecnolog\u00EDa (CONACYT; 2018-000009-01EXTF-00306), the Science, Technology & Innovation Funding Authority (STDF), Egypt-UK Newton-Mosharafa Institutional Links award, project ID 30718 and EG\u2013US cycle 19\u2013project ID 42687.Nature Research2024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://doi.org/10.1038/s41586-024-07682-9https://hdl.handle.net/10459.1/466820reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a https://doi.org/10.1038/s41586-024-07682-9Nature, 2024, vol. 632, núm. 8026, p. 823-831cc by (c) Cheng et al., 2024Attribution 4.0 Internationalinfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/oai:recercat.cat:10459.1/4668202026-05-29T05:05:01Z
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