Circulating markers of bone turnover

Renal osteodystrophy is a feature of chronic kidney disease (CKD), with increasing prevalence as CKD progresses. This bone disease is responsible for major morbidity, including fractures, and a deterioration in the quality of life and its sequelae. Circulating biomarkers of renal osteodystrophy typi...

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Autores: Vervloet, Marc G., Bover, Jordi|||0000-0003-3577-2273, Brandenburg, Vincent M., Covic, Adrian, Cozzolino, Mario|||0000-0002-8494-6252, Evenepoel, Pieter|||0000-0002-0797-4321, Goldsmith, David, Massy, Ziad, Mazzaferro, Sandro|||0000-0003-3071-1893, Ureña-Torres, Pablo|||0000-0001-6757-1906
Tipo de recurso: artículo
Fecha de publicación:2017
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:288450
Acceso en línea:https://ddd.uab.cat/record/288450
https://dx.doi.org/urn:doi:10.1007/s40620-017-0408-8
Access Level:acceso abierto
Palabra clave:Biomarkers
Bone turnover
CKD-MBD
Chronic kidney disease
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spelling Circulating markers of bone turnoverVervloet, Marc G.Bover, Jordi|||0000-0003-3577-2273Brandenburg, Vincent M.Covic, AdrianCozzolino, Mario|||0000-0002-8494-6252Evenepoel, Pieter|||0000-0002-0797-4321Goldsmith, DavidMassy, ZiadMazzaferro, Sandro|||0000-0003-3071-1893Ureña-Torres, Pablo|||0000-0001-6757-1906BiomarkersBone turnoverCKD-MBDChronic kidney diseaseRenal osteodystrophy is a feature of chronic kidney disease (CKD), with increasing prevalence as CKD progresses. This bone disease is responsible for major morbidity, including fractures, and a deterioration in the quality of life and its sequelae. Circulating biomarkers of renal osteodystrophy typically indicate bone turnover, but not other features of bone, like bone volume, mineralization, quality or strength. Bone turnover can be considered to be primarily a reflection of bone cell activity, in particular that of osteoblasts and osteoclasts. Since current treatments for bone disease usually target cellular activity, biomarkers are considered to be able to contribute to the decision-making for treatment and its follow-up. In CKD, one has to consider the impact of a diminished clearance of biomarkers or their altered metabolism, both potentially limiting its clinical use. Here, several aspects of the most frequently used biomarkers of bone turnover are reviewed, with an emphasis on the specific situation represented by CKD. This review is based on the overview lecture at the symposium held in Amsterdam, September 23, 2016: "The Bone In CKD", organized by the CKD-MBD working group of ERA-EDTA.Universitat Autònoma de Barcelona 22017-01-0120172017-01-01Article de revisióhttp://purl.org/coar/resource_type/c_dcae04bcVoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/288450https://dx.doi.org/urn:doi:10.1007/s40620-017-0408-8reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2884502026-06-06T12:50:31Z
dc.title.none.fl_str_mv Circulating markers of bone turnover
title Circulating markers of bone turnover
spellingShingle Circulating markers of bone turnover
Vervloet, Marc G.
Biomarkers
Bone turnover
CKD-MBD
Chronic kidney disease
title_short Circulating markers of bone turnover
title_full Circulating markers of bone turnover
title_fullStr Circulating markers of bone turnover
title_full_unstemmed Circulating markers of bone turnover
title_sort Circulating markers of bone turnover
dc.creator.none.fl_str_mv Vervloet, Marc G.
Bover, Jordi|||0000-0003-3577-2273
Brandenburg, Vincent M.
Covic, Adrian
Cozzolino, Mario|||0000-0002-8494-6252
Evenepoel, Pieter|||0000-0002-0797-4321
Goldsmith, David
Massy, Ziad
Mazzaferro, Sandro|||0000-0003-3071-1893
Ureña-Torres, Pablo|||0000-0001-6757-1906
author Vervloet, Marc G.
author_facet Vervloet, Marc G.
Bover, Jordi|||0000-0003-3577-2273
Brandenburg, Vincent M.
Covic, Adrian
Cozzolino, Mario|||0000-0002-8494-6252
Evenepoel, Pieter|||0000-0002-0797-4321
Goldsmith, David
Massy, Ziad
Mazzaferro, Sandro|||0000-0003-3071-1893
Ureña-Torres, Pablo|||0000-0001-6757-1906
author_role author
author2 Bover, Jordi|||0000-0003-3577-2273
Brandenburg, Vincent M.
Covic, Adrian
Cozzolino, Mario|||0000-0002-8494-6252
Evenepoel, Pieter|||0000-0002-0797-4321
Goldsmith, David
Massy, Ziad
Mazzaferro, Sandro|||0000-0003-3071-1893
Ureña-Torres, Pablo|||0000-0001-6757-1906
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universitat Autònoma de Barcelona
dc.subject.none.fl_str_mv Biomarkers
Bone turnover
CKD-MBD
Chronic kidney disease
topic Biomarkers
Bone turnover
CKD-MBD
Chronic kidney disease
description Renal osteodystrophy is a feature of chronic kidney disease (CKD), with increasing prevalence as CKD progresses. This bone disease is responsible for major morbidity, including fractures, and a deterioration in the quality of life and its sequelae. Circulating biomarkers of renal osteodystrophy typically indicate bone turnover, but not other features of bone, like bone volume, mineralization, quality or strength. Bone turnover can be considered to be primarily a reflection of bone cell activity, in particular that of osteoblasts and osteoclasts. Since current treatments for bone disease usually target cellular activity, biomarkers are considered to be able to contribute to the decision-making for treatment and its follow-up. In CKD, one has to consider the impact of a diminished clearance of biomarkers or their altered metabolism, both potentially limiting its clinical use. Here, several aspects of the most frequently used biomarkers of bone turnover are reviewed, with an emphasis on the specific situation represented by CKD. This review is based on the overview lecture at the symposium held in Amsterdam, September 23, 2016: "The Bone In CKD", organized by the CKD-MBD working group of ERA-EDTA.
publishDate 2017
dc.date.none.fl_str_mv 2
2017-01-01
2017
2017-01-01
dc.type.none.fl_str_mv Article de revisió
http://purl.org/coar/resource_type/c_dcae04bc
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/288450
https://dx.doi.org/urn:doi:10.1007/s40620-017-0408-8
url https://ddd.uab.cat/record/288450
https://dx.doi.org/urn:doi:10.1007/s40620-017-0408-8
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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