Longitudinal evaluation of neuroinflammation and oxidative stress in a mouse model of Alzheimer disease using positron emission tomography

Validation of new biomarkers of Alzheimer disease (AD) is crucial for the successful development and implementation of treatment strategies. Additional to traditional AT(N) biomarkers, neuroinflammation biomarkers, such as translocator protein (TSPO) and cystine/glutamine antiporter system (xc-), co...

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Detalles Bibliográficos
Autores: Rejc, Luka, Gómez-Vallejo, Vanessa, Joya, Ana, Arsequell, Gemma, Egimendia, Ander, Castellnou, Pilar, Ríos-Anglada, Xabier, Cossío, Unai, Baz, Zuriñe, Iglesias, Leyre, Capetillo-Zarate, Estibaliz, Ramos-Cabrer, Pedro, Martín, Abraham, Llop, Jordi
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/310902
Acceso en línea:http://hdl.handle.net/10261/310902
https://api.elsevier.com/content/abstract/scopus_id/85131647347
Access Level:acceso abierto
Palabra clave:TSPO
Alzheimer disease
Oxidative stress
Positron emission tomography
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Descripción
Sumario:Validation of new biomarkers of Alzheimer disease (AD) is crucial for the successful development and implementation of treatment strategies. Additional to traditional AT(N) biomarkers, neuroinflammation biomarkers, such as translocator protein (TSPO) and cystine/glutamine antiporter system (xc-), could be considered when assessing AD progression. Herein, we report the longitudinal investigation of [18F]DPA-714 and [18F]FSPG for their ability to detect TSPO and xc- biomarkers, respectively, in the 5xFAD mouse model for AD.

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