Synergistic effects of free radical scavengers and cochlear vasodilators: a new otoprotective strategy for age-related hearing loss

The growing increase in age-related hearing loss (ARHL), with its dramatic reduction in quality of life and significant increase in health care costs, is a catalyst to develop new therapeutic strategies to prevent or reduce this aging-associated condition. In this regard, there is extensive evidence...

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Autores: Alvarado Romero, Juan Carlos, Fuentes Santamaría, Verónica, Melgar Rojas, Pedro, Valero Hernández, María Llanos, Gabaldón Ull, María Cruz, Miller, Josef M., Juiz Gómez, José Manuel
Tipo de recurso: artículo
Fecha de publicación:2015
País:España
Institución:Universidad de Castilla-La Mancha
Repositorio:RUIdeRA. Repositorio Institucional de la UCLM
OAI Identifier:oai:ruidera.uclm.es:10578/33185
Acceso en línea:http://journal.frontiersin.org/article/10.3389/fnagi.2015.00086/abstract
https://hdl.handle.net/10578/33185
Access Level:acceso abierto
Palabra clave:Antioxidants
Cochlear blood flow
Hearing loss
Magnesium
Oxidative stress
Presbyacusis
Sensorineural
Vitamins
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spelling Synergistic effects of free radical scavengers and cochlear vasodilators: a new otoprotective strategy for age-related hearing lossAlvarado Romero, Juan CarlosFuentes Santamaría, VerónicaMelgar Rojas, PedroValero Hernández, María LlanosGabaldón Ull, María CruzMiller, Josef M.Juiz Gómez, José ManuelAntioxidantsCochlear blood flowHearing lossMagnesiumOxidative stressPresbyacusisSensorineuralVitaminsThe growing increase in age-related hearing loss (ARHL), with its dramatic reduction in quality of life and significant increase in health care costs, is a catalyst to develop new therapeutic strategies to prevent or reduce this aging-associated condition. In this regard, there is extensive evidence that excessive free radical formation along with diminished cochlear blood flow are essential factors involved in mechanisms of other stress-related hearing loss, such as that associated with noise or ototoxic drug exposure. The emerging view is that both play key roles in ARHL pathogenesis. Therapeutic targeting of excessive free radical formation and cochlear blood flow regulation may be a useful strategy to prevent onset of ARHL. Supporting this idea, micronutrient-based therapies, in particular those combining antioxidants and vasodilators like magnesium (Mg2+), have proven effective in reducing the impact of noise and ototoxic drugs in the inner ear, therefore improving auditory function. In this review, the synergistic effects of combinations of antioxidant free radicals scavengers and cochlear vasodilators will be discussed as a feasible therapeutic approach for the treatment of ARHL.Frontiers 202420242015info:eu-repo/semantics/articleapplication/pdfapplication/pdfhttp://journal.frontiersin.org/article/10.3389/fnagi.2015.00086/abstracthttps://hdl.handle.net/10578/33185reponame:RUIdeRA. Repositorio Institucional de la UCLMinstname:Universidad de Castilla-La ManchaInglésFP7-HEALTH-2012-INNOVATON 304925info:eu-repo/semantics/openAccessoai:ruidera.uclm.es:10578/331852026-05-27T07:36:41Z
dc.title.none.fl_str_mv Synergistic effects of free radical scavengers and cochlear vasodilators: a new otoprotective strategy for age-related hearing loss
title Synergistic effects of free radical scavengers and cochlear vasodilators: a new otoprotective strategy for age-related hearing loss
spellingShingle Synergistic effects of free radical scavengers and cochlear vasodilators: a new otoprotective strategy for age-related hearing loss
Alvarado Romero, Juan Carlos
Antioxidants
Cochlear blood flow
Hearing loss
Magnesium
Oxidative stress
Presbyacusis
Sensorineural
Vitamins
title_short Synergistic effects of free radical scavengers and cochlear vasodilators: a new otoprotective strategy for age-related hearing loss
title_full Synergistic effects of free radical scavengers and cochlear vasodilators: a new otoprotective strategy for age-related hearing loss
title_fullStr Synergistic effects of free radical scavengers and cochlear vasodilators: a new otoprotective strategy for age-related hearing loss
title_full_unstemmed Synergistic effects of free radical scavengers and cochlear vasodilators: a new otoprotective strategy for age-related hearing loss
title_sort Synergistic effects of free radical scavengers and cochlear vasodilators: a new otoprotective strategy for age-related hearing loss
dc.creator.none.fl_str_mv Alvarado Romero, Juan Carlos
Fuentes Santamaría, Verónica
Melgar Rojas, Pedro
Valero Hernández, María Llanos
Gabaldón Ull, María Cruz
Miller, Josef M.
Juiz Gómez, José Manuel
author Alvarado Romero, Juan Carlos
author_facet Alvarado Romero, Juan Carlos
Fuentes Santamaría, Verónica
Melgar Rojas, Pedro
Valero Hernández, María Llanos
Gabaldón Ull, María Cruz
Miller, Josef M.
Juiz Gómez, José Manuel
author_role author
author2 Fuentes Santamaría, Verónica
Melgar Rojas, Pedro
Valero Hernández, María Llanos
Gabaldón Ull, María Cruz
Miller, Josef M.
Juiz Gómez, José Manuel
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Antioxidants
Cochlear blood flow
Hearing loss
Magnesium
Oxidative stress
Presbyacusis
Sensorineural
Vitamins
topic Antioxidants
Cochlear blood flow
Hearing loss
Magnesium
Oxidative stress
Presbyacusis
Sensorineural
Vitamins
description The growing increase in age-related hearing loss (ARHL), with its dramatic reduction in quality of life and significant increase in health care costs, is a catalyst to develop new therapeutic strategies to prevent or reduce this aging-associated condition. In this regard, there is extensive evidence that excessive free radical formation along with diminished cochlear blood flow are essential factors involved in mechanisms of other stress-related hearing loss, such as that associated with noise or ototoxic drug exposure. The emerging view is that both play key roles in ARHL pathogenesis. Therapeutic targeting of excessive free radical formation and cochlear blood flow regulation may be a useful strategy to prevent onset of ARHL. Supporting this idea, micronutrient-based therapies, in particular those combining antioxidants and vasodilators like magnesium (Mg2+), have proven effective in reducing the impact of noise and ototoxic drugs in the inner ear, therefore improving auditory function. In this review, the synergistic effects of combinations of antioxidant free radicals scavengers and cochlear vasodilators will be discussed as a feasible therapeutic approach for the treatment of ARHL.
publishDate 2015
dc.date.none.fl_str_mv 2015
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://journal.frontiersin.org/article/10.3389/fnagi.2015.00086/abstract
https://hdl.handle.net/10578/33185
url http://journal.frontiersin.org/article/10.3389/fnagi.2015.00086/abstract
https://hdl.handle.net/10578/33185
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv FP7-HEALTH-2012-INNOVATON 304925
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Frontiers
publisher.none.fl_str_mv Frontiers
dc.source.none.fl_str_mv reponame:RUIdeRA. Repositorio Institucional de la UCLM
instname:Universidad de Castilla-La Mancha
instname_str Universidad de Castilla-La Mancha
reponame_str RUIdeRA. Repositorio Institucional de la UCLM
collection RUIdeRA. Repositorio Institucional de la UCLM
repository.name.fl_str_mv
repository.mail.fl_str_mv
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