Lower expression of plasma-derived exosome miR-21 levels in HIV-1 elite controllers with decreasing CD4 T cell count

Exosome-derived miR-21 was independently associated with CD4 T cell decline in HIV-1-infected elite controllers (OR 0.369, 95% CI 0.137-0.994, p = 0.049). Also, a negative correlation between miR-21 expression and MCP-1 level was found (r = -0.649, p = 0.020), while no correlation between soluble bi...

Descripción completa

Detalles Bibliográficos
Autores: Ruiz-de-León, M. J., Jiménez-Sousa, M. A., Moreno, S., García, M., Gutiérrez-Rivas, M., León, A., Vallejo, A., ECRIS network integrated in the Spanish AIDS research network, Muñoz Pérez, María Asunción, Rafii-El-Idrissi Benhnia, Mohammed, Leal Noval, Manuel
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Institución:Universidad de Sevilla (US)
Repositorio:idUS. Depósito de Investigación de la Universidad de Sevilla
OAI Identifier:oai:idus.us.es:11441/177164
Acceso en línea:https://hdl.handle.net/11441/177164
https://doi.org/ 10.1016/j.jmii.2018.07.007
Access Level:acceso abierto
Palabra clave:Elite controllers
Exosomes
HIV-1
Immune activation
Soluble biomarkers
miRNAs
Descripción
Sumario:Exosome-derived miR-21 was independently associated with CD4 T cell decline in HIV-1-infected elite controllers (OR 0.369, 95% CI 0.137-0.994, p = 0.049). Also, a negative correlation between miR-21 expression and MCP-1 level was found (r = -0.649, p = 0.020), while no correlation between soluble biomarkers or cellular immune activation was found.

Similares en LA Referencia