The positive rhinovirus/enterovirus detection and SARS-CoV-2 persistence beyond the acute infection phase: an intra-household surveillance study

This work was supported by the Kids Corona Project, Hospital Sant Joan de Déu, Barcelona, which received donations from Stavros Niarchos Foundation and Banco de Santander. ISGlobal receives support from the Spanish Ministry of Science and Innovation through the “Centro de Excelencia Severo Ochoa 201...

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Autores: Brotons de Los Reyes, Pedro, Jordan, Iolanda, Bassat, Quique, Henares, Desirée, Fernandez de Sevilla, Mariona, Ajanovic, Sara, Redin, Alba, Fumado, Vicky, Baro, Bàrbara, Claverol, Joana, Varo, Rosauro, Cuadras, Daniel, Hecht, Jochen, Barrabeig, Irene, Garcia-Garcia, Juan Jose, Launes, Cristian, Muñoz-Almagro, Carmen
Tipo de documento: artigo
Data de publicação:2021
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositório:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:20.500.12328/2765
Acesso em linha:http://hdl.handle.net/20.500.12328/2765
https://dx.doi.org/10.3390/v13081598
Access Level:Acceso aberto
Palavra-chave:COVID-19 (Malaltia)
Rinovirus
Nucli familiar
COVID-19
Núcleo familiar
Rhinovirus
Household
61
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spelling The positive rhinovirus/enterovirus detection and SARS-CoV-2 persistence beyond the acute infection phase: an intra-household surveillance studyBrotons de Los Reyes, PedroJordan, IolandaBassat, QuiqueHenares, DesiréeFernandez de Sevilla, MarionaAjanovic, SaraRedin, AlbaFumado, VickyBaro, BàrbaraClaverol, JoanaVaro, RosauroCuadras, DanielHecht, JochenBarrabeig, IreneGarcia-Garcia, Juan JoseLaunes, CristianMuñoz-Almagro, CarmenCOVID-19 (Malaltia)RinovirusNucli familiarCOVID-19RinovirusNúcleo familiarCOVID-19RhinovirusHousehold61This work was supported by the Kids Corona Project, Hospital Sant Joan de Déu, Barcelona, which received donations from Stavros Niarchos Foundation and Banco de Santander. ISGlobal receives support from the Spanish Ministry of Science and Innovation through the “Centro de Excelencia Severo Ochoa 2019–2023” Program (CEX2018-000806-S), and support from the Generalitat de Catalunya through the CERCA Program. CISM is supported by the Government of Mozambique and the Spanish Agency for International Development (AECID).We aimed to assess the duration of nasopharyngeal severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA persistence in adults self-confined at home after acute infection; and to identify the associations of SARS-CoV-2 persistence with respiratory virus co-detection and infection transmission. A cross-sectional intra-household study was conducted in metropolitan Barcelona (Spain) during the time period of April to June 2020. Every adult who was the first family member reported as SARS-CoV-2-positive by reverse transcription polymerase chain reaction (RT-PCR) as well as their household child contacts had nasopharyngeal swabs tested by a targeted SARS-CoV-2 RT-PCR and a multiplex viral respiratory panel after a 15 day minimum time lag. Four-hundred and four households (404 adults and 708 children) were enrolled. SARS-CoV-2 RNA was detected in 137 (33.9%) adults and 84 (11.9%) children. Rhinovirus/Enterovirus (RV/EV) was commonly found (83.3%) in co-infection with SARS-CoV-2 in adults. The mean duration of SARS-CoV-2 RNA presence in adults’ nasopharynx was 52 days (range 26–83 days). The persistence of SARS-CoV-2 was significantly associated with RV/EV co-infection (adjusted odds ratio (aOR) 9.31; 95% CI 2.57–33.80) and SARS-CoV-2 detection in child contacts (aOR 2.08; 95% CI 1.24–3.51). Prolonged nasopharyngeal SARS-CoV-2 RNA persistence beyond the acute infection phase was frequent in adults quarantined at home during the first epidemic wave; which was associated with RV/EV co-infection and could enhance intra-household infection transmission.info:eu-repo/semantics/publishedVersionMDPI2021info:eu-repo/semantics/article12http://hdl.handle.net/20.500.12328/2765https://dx.doi.org/10.3390/v13081598reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésViruses13;8This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:20.500.12328/27652026-05-29T05:05:01Z
dc.title.none.fl_str_mv The positive rhinovirus/enterovirus detection and SARS-CoV-2 persistence beyond the acute infection phase: an intra-household surveillance study
title The positive rhinovirus/enterovirus detection and SARS-CoV-2 persistence beyond the acute infection phase: an intra-household surveillance study
spellingShingle The positive rhinovirus/enterovirus detection and SARS-CoV-2 persistence beyond the acute infection phase: an intra-household surveillance study
Brotons de Los Reyes, Pedro
COVID-19 (Malaltia)
Rinovirus
Nucli familiar
COVID-19
Rinovirus
Núcleo familiar
COVID-19
Rhinovirus
Household
61
title_short The positive rhinovirus/enterovirus detection and SARS-CoV-2 persistence beyond the acute infection phase: an intra-household surveillance study
title_full The positive rhinovirus/enterovirus detection and SARS-CoV-2 persistence beyond the acute infection phase: an intra-household surveillance study
title_fullStr The positive rhinovirus/enterovirus detection and SARS-CoV-2 persistence beyond the acute infection phase: an intra-household surveillance study
title_full_unstemmed The positive rhinovirus/enterovirus detection and SARS-CoV-2 persistence beyond the acute infection phase: an intra-household surveillance study
title_sort The positive rhinovirus/enterovirus detection and SARS-CoV-2 persistence beyond the acute infection phase: an intra-household surveillance study
dc.creator.none.fl_str_mv Brotons de Los Reyes, Pedro
Jordan, Iolanda
Bassat, Quique
Henares, Desirée
Fernandez de Sevilla, Mariona
Ajanovic, Sara
Redin, Alba
Fumado, Vicky
Baro, Bàrbara
Claverol, Joana
Varo, Rosauro
Cuadras, Daniel
Hecht, Jochen
Barrabeig, Irene
Garcia-Garcia, Juan Jose
Launes, Cristian
Muñoz-Almagro, Carmen
author Brotons de Los Reyes, Pedro
author_facet Brotons de Los Reyes, Pedro
Jordan, Iolanda
Bassat, Quique
Henares, Desirée
Fernandez de Sevilla, Mariona
Ajanovic, Sara
Redin, Alba
Fumado, Vicky
Baro, Bàrbara
Claverol, Joana
Varo, Rosauro
Cuadras, Daniel
Hecht, Jochen
Barrabeig, Irene
Garcia-Garcia, Juan Jose
Launes, Cristian
Muñoz-Almagro, Carmen
author_role author
author2 Jordan, Iolanda
Bassat, Quique
Henares, Desirée
Fernandez de Sevilla, Mariona
Ajanovic, Sara
Redin, Alba
Fumado, Vicky
Baro, Bàrbara
Claverol, Joana
Varo, Rosauro
Cuadras, Daniel
Hecht, Jochen
Barrabeig, Irene
Garcia-Garcia, Juan Jose
Launes, Cristian
Muñoz-Almagro, Carmen
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv COVID-19 (Malaltia)
Rinovirus
Nucli familiar
COVID-19
Rinovirus
Núcleo familiar
COVID-19
Rhinovirus
Household
61
topic COVID-19 (Malaltia)
Rinovirus
Nucli familiar
COVID-19
Rinovirus
Núcleo familiar
COVID-19
Rhinovirus
Household
61
description This work was supported by the Kids Corona Project, Hospital Sant Joan de Déu, Barcelona, which received donations from Stavros Niarchos Foundation and Banco de Santander. ISGlobal receives support from the Spanish Ministry of Science and Innovation through the “Centro de Excelencia Severo Ochoa 2019–2023” Program (CEX2018-000806-S), and support from the Generalitat de Catalunya through the CERCA Program. CISM is supported by the Government of Mozambique and the Spanish Agency for International Development (AECID).
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12328/2765
https://dx.doi.org/10.3390/v13081598
url http://hdl.handle.net/20.500.12328/2765
https://dx.doi.org/10.3390/v13081598
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Viruses
13;8
dc.rights.none.fl_str_mv https://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 12
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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