Modeling modulation of the tick regulome in response to Anaplasma phagocytophilum for the identification of new control targets

Ticks act as vectors of pathogens affecting human and animal health worldwide, and recent research has focused on the characterization of tick-pathogen interactions using omics technologies to identify new targets for developing novel control interventions. The regulome (transcription factors-target...

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Autores: Artigas Jerónimo, Sara, Estrada Peña, Agustín, Cabezas Cruz, Alejandro, Alberdi Vélez, María Pilar, Villar Rayo, Margarita María, Fuente García, José de Jesús de la
Tipo de recurso: artículo
Fecha de publicación:2019
País:España
Institución:Universidad de Castilla-La Mancha
Repositorio:RUIdeRA. Repositorio Institucional de la UCLM
OAI Identifier:oai:ruidera.uclm.es:10578/22958
Acceso en línea:http://hdl.handle.net/10578/22958
Access Level:acceso abierto
Palabra clave:Transcription
Tick
Ixodes scapularis
Anaplasma phagocytophilum
ISE6 cells
Vaccine
Rgulome
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oai_identifier_str oai:ruidera.uclm.es:10578/22958
network_acronym_str ES
network_name_str España
repository_id_str
spelling Modeling modulation of the tick regulome in response to Anaplasma phagocytophilum for the identification of new control targetsArtigas Jerónimo, SaraEstrada Peña, AgustínCabezas Cruz, AlejandroAlberdi Vélez, María PilarVillar Rayo, Margarita MaríaFuente García, José de Jesús de laTranscriptionTickIxodes scapularisAnaplasma phagocytophilumISE6 cellsVaccineRgulomeTicks act as vectors of pathogens affecting human and animal health worldwide, and recent research has focused on the characterization of tick-pathogen interactions using omics technologies to identify new targets for developing novel control interventions. The regulome (transcription factors-target genes interactions) plays a critical role in cell response to pathogen infection. Therefore, the application of regulomics to tick-pathogen interactions would advance our understanding of these molecular interactions and contribute to the identification of novel control targets for the prevention and control of tick infestations and tick-borne diseases. However, limited information is available on the role of tick regulome in response to pathogen infection. In this study, we applied complementary in silico approaches to modeling how Anaplasma phagocytophilum infection modulates tick vector regulome. This proof-of-concept research provided support for the use of network analysis in the study of regulome response to infection, resulting in new information on tick-pathogen interactions and potential targets for developing interventions for the control of tick infestations and pathogen transmission. Deciphering the precise nature of circuits that shape the tick regulome in response to pathogen infection is an area of research that in the future will advance our knowledge of tick-pathogen interactions, and the identification of new antigens for the control of tick infestations and pathogen infection/transmission.Frontiers202020202019info:eu-repo/semantics/articleapplication/pdfapplication/pdfhttp://hdl.handle.net/10578/22958reponame:RUIdeRA. Repositorio Institucional de la UCLMinstname:Universidad de Castilla-La ManchaInglésinfo:eu-repo/semantics/openAccessoai:ruidera.uclm.es:10578/229582026-05-27T07:36:41Z
dc.title.none.fl_str_mv Modeling modulation of the tick regulome in response to Anaplasma phagocytophilum for the identification of new control targets
title Modeling modulation of the tick regulome in response to Anaplasma phagocytophilum for the identification of new control targets
spellingShingle Modeling modulation of the tick regulome in response to Anaplasma phagocytophilum for the identification of new control targets
Artigas Jerónimo, Sara
Transcription
Tick
Ixodes scapularis
Anaplasma phagocytophilum
ISE6 cells
Vaccine
Rgulome
title_short Modeling modulation of the tick regulome in response to Anaplasma phagocytophilum for the identification of new control targets
title_full Modeling modulation of the tick regulome in response to Anaplasma phagocytophilum for the identification of new control targets
title_fullStr Modeling modulation of the tick regulome in response to Anaplasma phagocytophilum for the identification of new control targets
title_full_unstemmed Modeling modulation of the tick regulome in response to Anaplasma phagocytophilum for the identification of new control targets
title_sort Modeling modulation of the tick regulome in response to Anaplasma phagocytophilum for the identification of new control targets
dc.creator.none.fl_str_mv Artigas Jerónimo, Sara
Estrada Peña, Agustín
Cabezas Cruz, Alejandro
Alberdi Vélez, María Pilar
Villar Rayo, Margarita María
Fuente García, José de Jesús de la
author Artigas Jerónimo, Sara
author_facet Artigas Jerónimo, Sara
Estrada Peña, Agustín
Cabezas Cruz, Alejandro
Alberdi Vélez, María Pilar
Villar Rayo, Margarita María
Fuente García, José de Jesús de la
author_role author
author2 Estrada Peña, Agustín
Cabezas Cruz, Alejandro
Alberdi Vélez, María Pilar
Villar Rayo, Margarita María
Fuente García, José de Jesús de la
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Transcription
Tick
Ixodes scapularis
Anaplasma phagocytophilum
ISE6 cells
Vaccine
Rgulome
topic Transcription
Tick
Ixodes scapularis
Anaplasma phagocytophilum
ISE6 cells
Vaccine
Rgulome
description Ticks act as vectors of pathogens affecting human and animal health worldwide, and recent research has focused on the characterization of tick-pathogen interactions using omics technologies to identify new targets for developing novel control interventions. The regulome (transcription factors-target genes interactions) plays a critical role in cell response to pathogen infection. Therefore, the application of regulomics to tick-pathogen interactions would advance our understanding of these molecular interactions and contribute to the identification of novel control targets for the prevention and control of tick infestations and tick-borne diseases. However, limited information is available on the role of tick regulome in response to pathogen infection. In this study, we applied complementary in silico approaches to modeling how Anaplasma phagocytophilum infection modulates tick vector regulome. This proof-of-concept research provided support for the use of network analysis in the study of regulome response to infection, resulting in new information on tick-pathogen interactions and potential targets for developing interventions for the control of tick infestations and pathogen transmission. Deciphering the precise nature of circuits that shape the tick regulome in response to pathogen infection is an area of research that in the future will advance our knowledge of tick-pathogen interactions, and the identification of new antigens for the control of tick infestations and pathogen infection/transmission.
publishDate 2019
dc.date.none.fl_str_mv 2019
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10578/22958
url http://hdl.handle.net/10578/22958
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Frontiers
publisher.none.fl_str_mv Frontiers
dc.source.none.fl_str_mv reponame:RUIdeRA. Repositorio Institucional de la UCLM
instname:Universidad de Castilla-La Mancha
instname_str Universidad de Castilla-La Mancha
reponame_str RUIdeRA. Repositorio Institucional de la UCLM
collection RUIdeRA. Repositorio Institucional de la UCLM
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.300719

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