Bone adhesive with temporally-synchronized degradation for enhanced osteointegration

Bone adhesives have emerged as promising alternatives for complex fracture fixation. However, discrepancies between material degradation rates and the physiological timeline of bone healing remain a critical limitation. Here, a polyurethane-based adhesive (TNC) was developed, synthesized from trimer...

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Detalles Bibliográficos
Autores: Gu, JunTing, Li, ZhiTing, Wang, Yuzhu, Hao, Dongxiao, Dang, Gaopeng, Cao, XiaoQing, Tay, Franklin, Chen, JiHua, Aparicio Bádenas, Conrado José|||0000-0003-2969-6067, Jiao, Kai, Niu, Lina|||0000-0002-6653-0819
Tipo de recurso: artículo
Fecha de publicación:2026
País:España
Institución:Universitat Politècnica de Catalunya (UPC)
Repositorio:UPCommons. Portal del coneixement obert de la UPC
Idioma:inglés
OAI Identifier:oai:dnet:upcommonspor::1e67784fbd8036d08cd5e29e9d88d57f
Acceso en línea:https://hdl.handle.net/2117/460963
https://dx.doi.org/10.1038/s41413-026-00522-8
Access Level:acceso abierto
Palabra clave:Bone
Bone quality and biomechanics
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spelling Bone adhesive with temporally-synchronized degradation for enhanced osteointegrationGu, JunTingLi, ZhiTingWang, YuzhuHao, DongxiaoDang, GaopengCao, XiaoQingTay, FranklinChen, JiHuaAparicio Bádenas, Conrado José|||0000-0003-2969-6067Jiao, KaiNiu, Lina|||0000-0002-6653-0819BoneBone quality and biomechanicsBone adhesives have emerged as promising alternatives for complex fracture fixation. However, discrepancies between material degradation rates and the physiological timeline of bone healing remain a critical limitation. Here, a polyurethane-based adhesive (TNC) was developed, synthesized from trimeric hexamethylene diisocyanate, nano-hydroxyapatite, and type I collagen. The TNC demonstrates strong initial adhesion to both wet and blood-contaminated bone surfaces and exhibits excellent biocompatibility. A distinguishing feature of TNC is its capacity to synchronize degradation with the stages of bone healing. During degradation, TNC forms a mineralized surface layer that releases calcium ions. The calcium ions activate cathepsin K, an enzyme integral to bone remodeling. This calcium-mediated mechanism accelerates TNC degradation by 1.9-fold during the remodeling phase compared to the initial phase. In a rat skull fracture model, TNC supported effective fracture stabilization and achieved favorable bone regeneration at 8 weeks after implantation. These findings demonstrate that TNC combines early mechanical stability with phase-specific degradability to facilitate bone regeneration in a temporally-controlled manner. The present work provides a framework for the development of bio-responsive bone adhesives that synchronize degradation behavior with healing phases for orthopedic applications.This work was supported by the National Natural Science Foundation of China (82301043, 82325012), China Postdoctoral Science Foundation grant (GZC20233582, 2024M754269), Young Elite Scientist Support Program by CSA (2024PYRC001), Young Talent Support Program of Shaanxi Province (20240304).Springer20262026-04-0720262026-04-24journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/2117/460963https://dx.doi.org/10.1038/s41413-026-00522-8reponame:UPCommons. Portal del coneixement obert de la UPCinstname:Universitat Politècnica de Catalunya (UPC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:dnet:upcommonspor::1e67784fbd8036d08cd5e29e9d88d57f2026-05-27T15:37:01Z
dc.title.none.fl_str_mv Bone adhesive with temporally-synchronized degradation for enhanced osteointegration
title Bone adhesive with temporally-synchronized degradation for enhanced osteointegration
spellingShingle Bone adhesive with temporally-synchronized degradation for enhanced osteointegration
Gu, JunTing
Bone
Bone quality and biomechanics
title_short Bone adhesive with temporally-synchronized degradation for enhanced osteointegration
title_full Bone adhesive with temporally-synchronized degradation for enhanced osteointegration
title_fullStr Bone adhesive with temporally-synchronized degradation for enhanced osteointegration
title_full_unstemmed Bone adhesive with temporally-synchronized degradation for enhanced osteointegration
title_sort Bone adhesive with temporally-synchronized degradation for enhanced osteointegration
dc.creator.none.fl_str_mv Gu, JunTing
Li, ZhiTing
Wang, Yuzhu
Hao, Dongxiao
Dang, Gaopeng
Cao, XiaoQing
Tay, Franklin
Chen, JiHua
Aparicio Bádenas, Conrado José|||0000-0003-2969-6067
Jiao, Kai
Niu, Lina|||0000-0002-6653-0819
author Gu, JunTing
author_facet Gu, JunTing
Li, ZhiTing
Wang, Yuzhu
Hao, Dongxiao
Dang, Gaopeng
Cao, XiaoQing
Tay, Franklin
Chen, JiHua
Aparicio Bádenas, Conrado José|||0000-0003-2969-6067
Jiao, Kai
Niu, Lina|||0000-0002-6653-0819
author_role author
author2 Li, ZhiTing
Wang, Yuzhu
Hao, Dongxiao
Dang, Gaopeng
Cao, XiaoQing
Tay, Franklin
Chen, JiHua
Aparicio Bádenas, Conrado José|||0000-0003-2969-6067
Jiao, Kai
Niu, Lina|||0000-0002-6653-0819
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Bone
Bone quality and biomechanics
topic Bone
Bone quality and biomechanics
description Bone adhesives have emerged as promising alternatives for complex fracture fixation. However, discrepancies between material degradation rates and the physiological timeline of bone healing remain a critical limitation. Here, a polyurethane-based adhesive (TNC) was developed, synthesized from trimeric hexamethylene diisocyanate, nano-hydroxyapatite, and type I collagen. The TNC demonstrates strong initial adhesion to both wet and blood-contaminated bone surfaces and exhibits excellent biocompatibility. A distinguishing feature of TNC is its capacity to synchronize degradation with the stages of bone healing. During degradation, TNC forms a mineralized surface layer that releases calcium ions. The calcium ions activate cathepsin K, an enzyme integral to bone remodeling. This calcium-mediated mechanism accelerates TNC degradation by 1.9-fold during the remodeling phase compared to the initial phase. In a rat skull fracture model, TNC supported effective fracture stabilization and achieved favorable bone regeneration at 8 weeks after implantation. These findings demonstrate that TNC combines early mechanical stability with phase-specific degradability to facilitate bone regeneration in a temporally-controlled manner. The present work provides a framework for the development of bio-responsive bone adhesives that synchronize degradation behavior with healing phases for orthopedic applications.
publishDate 2026
dc.date.none.fl_str_mv 2026
2026-04-07
2026
2026-04-24
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/2117/460963
https://dx.doi.org/10.1038/s41413-026-00522-8
url https://hdl.handle.net/2117/460963
https://dx.doi.org/10.1038/s41413-026-00522-8
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:UPCommons. Portal del coneixement obert de la UPC
instname:Universitat Politècnica de Catalunya (UPC)
instname_str Universitat Politècnica de Catalunya (UPC)
reponame_str UPCommons. Portal del coneixement obert de la UPC
collection UPCommons. Portal del coneixement obert de la UPC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.811543

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