Common Genetic Variation and Age of Onset of Anorexia Nervosa

Background Genetics and biology may influence the age of onset of anorexia nervosa (AN). The aims of this study were to determine whether common genetic variation contributes to age of onset of AN and to investigate the genetic associations between age of onset of AN and age at menarche. Methods A s...

Descripción completa

Detalles Bibliográficos
Autores: Watson, Hunna J., Thornton, Laura M., Yilmaz, Zeynep, Baker, Jessica H., Coleman, Jonathan R. I., Adan, Roger A. H., Alfredsson, Lars, Andreassen, Ole A., Ask, Helga, Berrettini, Wade H., Boehnke, Michael, Scherag, André, Scherer, Stephen W., Schmidt, Ulrike, Scott, Laura J., Seitz, Jochen, Silén, Yasmina, Slachtova, Lenka, Slagboom, P. Eline, Slof-Op't Landt, Margarita C. T., Dedoussis, George, Ehrlich, Stefan, Buehren, Katharina, Slopien, Agnieszka, Sorbi, Sandro, Swiqtkowska, Beata, Tortorella, Alfonso, Tozzi, Federica, Treasure, Janet, Tsitsika, Artemis, Tyszkiewicz-Nwafor, Marta, Tziouvas, Konstantinos, Eriksson, Johan G., DeSocio, Janiece E., Elburg, Annemarie A. van, Bulant, Josef, Furth, Eric F. van, Walton, Esther, Widen, Elisabeth, Zerwas, Stephanie, Zipfel, Stephan, Bergen, Andrew W., Boden, Joseph M., Escaramís Babiano, Geòrgia, Brandt, Harry, Dick, Danielle M., Crawford, Steven, Halmi, Katherine A., Burghardt, Roland, Horwood, L. John, Johnson, Craig, Kaplan, Allan S., Kaye, Walter H., Mitchell, James E., Esko, Tõnu, Olsen, Catherine M., Pearson, John F., Dikeos, Dimitris, Pedersen, Nancy L., Strober, Michael, Werge, Thomas, Chang, Xiao, Whiteman, David C., Woodside, D. Blake, Gordon, Scott, Estivill, Xavier, 1955-, Maguire, Sarah, Larsen, Janne T., Parker, Richard, Dina, Christian, Petersen, Liselotte Vogdrup, Jordan, Jennifer, Kennedy, Martin, Wade, Tracey D., Cichon, Sven, Birgegård, Andreas, Farmer, Anne, Lichtenstein, Paul, Landén, Mikael, Martin, Nicholas G., Mortensen, Preben Bo, Djurovic, Srdjan, Breen, Gerome, Bulik, Cynthia M., Cone, Roger D., Courtet, Philippe, Crow, Scott, Fernández Aranda, Fernando, Crowley, James J., Danner, Unna N., Dmitrzak-Weglarz, Monika, Docampo Martínez, Elisa, Duriez, Philibert, Monteleone, Palmiero, Egberts, Karin, Fichter, Manfred M., Föcker, Manuel, Myers, Richard, Ramoz, Nicolás, Foretova, Lenka, Forstner, Andreas J., Frei, Oleksandr, Gallinger, Steven, Giegling, Ina, Giuranna, Johanna, Gonidakis, Fragiskos, Gorwood, Philip, Gratacòs, Mònica, Guillaume, Sébastien, Reichborn-Kjennerud, Ted, Navratilova, Marie, Guo, Yiran, Hakonarson, Hakon, Hauser, Joanna, Havdahl, Alexandra, Hebebrand, Johannes, Helder, Sietske G., Herms, Stefan, Herpertz-Dahlmann, Beate, Herzog, Wolfgang, Ricca, Valdo, Hinney, Anke, Ntalla, Ioanna, Hübel, Christopher, Hudson, James I., Imgart, Hartmut, Jamain, Stephanie, Janout, Vladimir, Jiménez-Murcia, Susana, Jones, Ian R., Julià, Antonio, Ripatti, Samuli, Kalsi, Gursharan, Kaminská, Deborah, O'Toole, Julie K., Kaprio, Jaakko, Karhunen, Leila, Kas, Martien J. H., Keel, Pamela P., Kennedy, James L., Keski-Rahkonen, Anna, Kiezebrink, Kirsty, Ripke, Stephan, Klareskog, Lars, Klump, Kelly L., Knudsen, Gun Peggy S., Ophoff, Roel A., Via, Maria C. La, Le Hellard, Stephanie, Leboyer, Marion, Li, Dong, Lilenfeld, Lisa, Lin, Bochao, Ritschel, Franziska, Lissowska, Jolanta, Luykx, Jurjen, Magistretti, Pierre J., Maj, Mario, Padyukov, Leonid, Marsal Barril, Sara, Marshall, Christian R., Mattingsdal, Morten, Meulenbelt, Ingrid, Micali, Nadia, Roberts, Marion, Mitchell, Karen S., Monteleone, Alessio Maria, Pantel, Jacques, Papezova, Hana, Pinto, Dalila, Boehm, Ilka, Raevuori, Anu, Rotondo, Alessandro, Rujescu, Dan, Boni, Claudette, Zwaan, Martina de, Rybakowski, Filip
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/205025
Acceso en línea:https://hdl.handle.net/2445/205025
Access Level:acceso abierto
Palabra clave:Anorèxia nerviosa
Genètica
Lleis de Mendel
Anorexia nervosa
Genetics
Mendel's law
Descripción
Sumario:Background Genetics and biology may influence the age of onset of anorexia nervosa (AN). The aims of this study were to determine whether common genetic variation contributes to age of onset of AN and to investigate the genetic associations between age of onset of AN and age at menarche. Methods A secondary analysis of the Psychiatric Genomics Consortium genome-wide association study (GWAS) of AN was performed, which included 9335 cases and 31,981 screened controls, all from European ancestries. We conducted GWASs of age of onset, early-onset AN (<13 years), and typical-onset AN, and genetic correlation, genetic risk score, and Mendelian randomization analyses. Results Two loci were genome-wide significant in the typical-onset AN GWAS. Heritability estimates (single nucleotide polymorphism–h2) were 0.01–0.04 for age of onset, 0.16–0.25 for early-onset AN, and 0.17–0.25 for typical-onset AN. Early- and typical-onset AN showed distinct genetic correlation patterns with putative risk factors for AN. Specifically, early-onset AN was significantly genetically correlated with younger age at menarche, and typical-onset AN was significantly negatively genetically correlated with anthropometric traits. Genetic risk scores for age of onset and early-onset AN estimated from independent GWASs significantly predicted age of onset. Mendelian randomization analysis suggested a causal link between younger age at menarche and early-onset AN. Conclusions Our results provide evidence consistent with a common variant genetic basis for age of onset and implicate biological pathways regulating menarche and reproduction.

Similares en LA Referencia