Viral enhancer mimicry of host innate-immune promoters

The inflammatory milieu is the natural habitat for a pathogenic infection, characterised by activity of pro-inflammatory signalling pathways and inflammatory cytokines. Viral entry rapidly activates a range of innate-immune signalling events such as the activation of Pattern Recognition Receptors (P...

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Detalles Bibliográficos
Autores: Kropp, Kai Alexander, Angulo Aguado, Ana, Ghazal, Peter
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2014
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/113830
Acceso en línea:https://hdl.handle.net/2445/113830
Access Level:acceso abierto
Palabra clave:Virologia molecular
Expressió gènica
Virus
Molecular virology
Gene expression
Viruses
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spelling Viral enhancer mimicry of host innate-immune promotersKropp, Kai AlexanderAngulo Aguado, AnaGhazal, PeterVirologia molecularExpressió gènicaVirusMolecular virologyGene expressionVirusesThe inflammatory milieu is the natural habitat for a pathogenic infection, characterised by activity of pro-inflammatory signalling pathways and inflammatory cytokines. Viral entry rapidly activates a range of innate-immune signalling events such as the activation of Pattern Recognition Receptors (PRRs) [1]-[5]. A virus must therefore counteract intrinsic cellular and innate-immune responses to successfully complete the replication cycle. Frequently this is accomplished by encoding viral effector molecules that block these cellular responses by working as either structural or functional mimics of host target proteins [6]-[11]. Nuclear DNA viruses are dependent on the host transcriptional machinery to express the first viral genes; for example the immediate-early (IE) control elements of DNA viruses are by definition absolutely dependent on host transcription factors (TF) [12]. Therefore, these viruses are particularly hostage to their host transcriptional environment [13], [14]. Here we propose that mimicry of regulatory DNA sequences by viral regulatory regions may also provide an additional strategy to counteract at IE times of infection the innate-immune response. In this context, viral IE control elements might functionally mimic innate-immune enhancers, taking advantage of the activated immune signalling TFs for promoting viral IE gene expression.Public Library of Science (PLoS)2017201720142017info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion7 p.application/pdfhttps://hdl.handle.net/2445/113830Articles publicats en revistes (Biomedicina)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1371/journal.ppat.1003804PLoS Pathogens, 2014, vol. 10, num. 2, p. e1003804https://doi.org/10.1371/journal.ppat.1003804cc-by (c) Kropp, Kai A. et al., 2014http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:recercat.cat:2445/1138302026-05-29T05:05:01Z
dc.title.none.fl_str_mv Viral enhancer mimicry of host innate-immune promoters
title Viral enhancer mimicry of host innate-immune promoters
spellingShingle Viral enhancer mimicry of host innate-immune promoters
Kropp, Kai Alexander
Virologia molecular
Expressió gènica
Virus
Molecular virology
Gene expression
Viruses
title_short Viral enhancer mimicry of host innate-immune promoters
title_full Viral enhancer mimicry of host innate-immune promoters
title_fullStr Viral enhancer mimicry of host innate-immune promoters
title_full_unstemmed Viral enhancer mimicry of host innate-immune promoters
title_sort Viral enhancer mimicry of host innate-immune promoters
dc.creator.none.fl_str_mv Kropp, Kai Alexander
Angulo Aguado, Ana
Ghazal, Peter
author Kropp, Kai Alexander
author_facet Kropp, Kai Alexander
Angulo Aguado, Ana
Ghazal, Peter
author_role author
author2 Angulo Aguado, Ana
Ghazal, Peter
author2_role author
author
dc.subject.none.fl_str_mv Virologia molecular
Expressió gènica
Virus
Molecular virology
Gene expression
Viruses
topic Virologia molecular
Expressió gènica
Virus
Molecular virology
Gene expression
Viruses
description The inflammatory milieu is the natural habitat for a pathogenic infection, characterised by activity of pro-inflammatory signalling pathways and inflammatory cytokines. Viral entry rapidly activates a range of innate-immune signalling events such as the activation of Pattern Recognition Receptors (PRRs) [1]-[5]. A virus must therefore counteract intrinsic cellular and innate-immune responses to successfully complete the replication cycle. Frequently this is accomplished by encoding viral effector molecules that block these cellular responses by working as either structural or functional mimics of host target proteins [6]-[11]. Nuclear DNA viruses are dependent on the host transcriptional machinery to express the first viral genes; for example the immediate-early (IE) control elements of DNA viruses are by definition absolutely dependent on host transcription factors (TF) [12]. Therefore, these viruses are particularly hostage to their host transcriptional environment [13], [14]. Here we propose that mimicry of regulatory DNA sequences by viral regulatory regions may also provide an additional strategy to counteract at IE times of infection the innate-immune response. In this context, viral IE control elements might functionally mimic innate-immune enhancers, taking advantage of the activated immune signalling TFs for promoting viral IE gene expression.
publishDate 2014
dc.date.none.fl_str_mv 2014
2017
2017
2017
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/113830
url https://hdl.handle.net/2445/113830
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1371/journal.ppat.1003804
PLoS Pathogens, 2014, vol. 10, num. 2, p. e1003804
https://doi.org/10.1371/journal.ppat.1003804
dc.rights.none.fl_str_mv cc-by (c) Kropp, Kai A. et al., 2014
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Kropp, Kai A. et al., 2014
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 7 p.
application/pdf
dc.publisher.none.fl_str_mv Public Library of Science (PLoS)
publisher.none.fl_str_mv Public Library of Science (PLoS)
dc.source.none.fl_str_mv Articles publicats en revistes (Biomedicina)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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