Is the ACE I/D polymorphism associated with extreme longevity? A study on a Spanish cohort

The 287 bp Ins(I)/Del(D) polymorphism [rs1799752] in intron 16 of the angiotensin-converting enzyme (ACE) gene has been associated with extreme longevity (>= 100 years) in some Caucasian and Asian cohorts, but this finding was not corroborated in other reports. We compared the allelic/genotypic f...

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Autores: Fiuza Luces, María del Carmen, Ruiz, Jonatan R., Cano-Nieto, Amalia, Garatachea, Nuria, Rodríguez-Moreno, Inmaculada, Morán, María, Rodríguez Romo, Gabriel, Santiago Dorrego, Catalina, Gómez Gallego, Félix, Lucía Mulas, Alejandro
Tipo de recurso: artículo
Fecha de publicación:2011
País:España
Institución:Universidad Europea (UEM)
Repositorio:ABACUS. Repositorio de Producción Científica
Idioma:inglés
OAI Identifier:oai:abacus.universidadeuropea.com:11268/1149
Acceso en línea:http://hdl.handle.net/11268/1149
Access Level:acceso abierto
Palabra clave:Genética humana
Envejecimiento
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spelling Is the ACE I/D polymorphism associated with extreme longevity? A study on a Spanish cohortFiuza Luces, María del CarmenRuiz, Jonatan R.Cano-Nieto, AmaliaGaratachea, NuriaRodríguez-Moreno, InmaculadaMorán, MaríaRodríguez Romo, GabrielSantiago Dorrego, CatalinaGómez Gallego, FélixLucía Mulas, AlejandroGenética humanaEnvejecimientoThe 287 bp Ins(I)/Del(D) polymorphism [rs1799752] in intron 16 of the angiotensin-converting enzyme (ACE) gene has been associated with extreme longevity (>= 100 years) in some Caucasian and Asian cohorts, but this finding was not corroborated in other reports. We compared the allelic/genotypic frequency of the ACE I/D polymorphism among centenarians (N = 64, 100-108 years, 89.1% female) and nonagenarians (N = 47, 90-97 years, 76.6% female), and a control group of healthy young adults (n = 434, age 20-40 years, 50% female). All participants were of the same Caucasian (Spanish) descent. The ACE I/D genotype met Hardy-Weinberg expectations in all the cohorts. Allelic and genotypic frequencies did not differ by sex in any of the study groups (all p > 0.2). There were no differences in allelic or genotypic frequencies between groups, for example the frequency of the D allele was 62.3% in controls vs. 65.3% in the elderly (64.8% in centenarians). In summary, the ACE I/D polymorphism is not significantly associated with extreme longevity in the Spanish population. Further research is, however, necessary using other approaches. It also remains to be determined if the interaction of ACE genotypes with some other genetic variants exerts a potential effect on longevity.20132013-11-2720112011-01-0120112011-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articlehttp://hdl.handle.net/11268/1149reponame:ABACUS. Repositorio de Producción Científicainstname:Universidad Europea (UEM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:abacus.universidadeuropea.com:11268/11492026-06-11T12:41:27Z
dc.title.none.fl_str_mv Is the ACE I/D polymorphism associated with extreme longevity? A study on a Spanish cohort
title Is the ACE I/D polymorphism associated with extreme longevity? A study on a Spanish cohort
spellingShingle Is the ACE I/D polymorphism associated with extreme longevity? A study on a Spanish cohort
Fiuza Luces, María del Carmen
Genética humana
Envejecimiento
title_short Is the ACE I/D polymorphism associated with extreme longevity? A study on a Spanish cohort
title_full Is the ACE I/D polymorphism associated with extreme longevity? A study on a Spanish cohort
title_fullStr Is the ACE I/D polymorphism associated with extreme longevity? A study on a Spanish cohort
title_full_unstemmed Is the ACE I/D polymorphism associated with extreme longevity? A study on a Spanish cohort
title_sort Is the ACE I/D polymorphism associated with extreme longevity? A study on a Spanish cohort
dc.creator.none.fl_str_mv Fiuza Luces, María del Carmen
Ruiz, Jonatan R.
Cano-Nieto, Amalia
Garatachea, Nuria
Rodríguez-Moreno, Inmaculada
Morán, María
Rodríguez Romo, Gabriel
Santiago Dorrego, Catalina
Gómez Gallego, Félix
Lucía Mulas, Alejandro
author Fiuza Luces, María del Carmen
author_facet Fiuza Luces, María del Carmen
Ruiz, Jonatan R.
Cano-Nieto, Amalia
Garatachea, Nuria
Rodríguez-Moreno, Inmaculada
Morán, María
Rodríguez Romo, Gabriel
Santiago Dorrego, Catalina
Gómez Gallego, Félix
Lucía Mulas, Alejandro
author_role author
author2 Ruiz, Jonatan R.
Cano-Nieto, Amalia
Garatachea, Nuria
Rodríguez-Moreno, Inmaculada
Morán, María
Rodríguez Romo, Gabriel
Santiago Dorrego, Catalina
Gómez Gallego, Félix
Lucía Mulas, Alejandro
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv Genética humana
Envejecimiento
topic Genética humana
Envejecimiento
description The 287 bp Ins(I)/Del(D) polymorphism [rs1799752] in intron 16 of the angiotensin-converting enzyme (ACE) gene has been associated with extreme longevity (>= 100 years) in some Caucasian and Asian cohorts, but this finding was not corroborated in other reports. We compared the allelic/genotypic frequency of the ACE I/D polymorphism among centenarians (N = 64, 100-108 years, 89.1% female) and nonagenarians (N = 47, 90-97 years, 76.6% female), and a control group of healthy young adults (n = 434, age 20-40 years, 50% female). All participants were of the same Caucasian (Spanish) descent. The ACE I/D genotype met Hardy-Weinberg expectations in all the cohorts. Allelic and genotypic frequencies did not differ by sex in any of the study groups (all p > 0.2). There were no differences in allelic or genotypic frequencies between groups, for example the frequency of the D allele was 62.3% in controls vs. 65.3% in the elderly (64.8% in centenarians). In summary, the ACE I/D polymorphism is not significantly associated with extreme longevity in the Spanish population. Further research is, however, necessary using other approaches. It also remains to be determined if the interaction of ACE genotypes with some other genetic variants exerts a potential effect on longevity.
publishDate 2011
dc.date.none.fl_str_mv 2011
2011-01-01
2011
2011-01-01
2013
2013-11-27
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/11268/1149
url http://hdl.handle.net/11268/1149
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:ABACUS. Repositorio de Producción Científica
instname:Universidad Europea (UEM)
instname_str Universidad Europea (UEM)
reponame_str ABACUS. Repositorio de Producción Científica
collection ABACUS. Repositorio de Producción Científica
repository.name.fl_str_mv
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