Genomic surveillance reveals different transmission patterns between third-generation cephalosporin and carbapenem resistance in Klebsiella pneumoniae in the Comunidad Valenciana (Spain), 2018-2020

BackgroundThe emergence and spread of third-generation cephalosporins (3GC) and carbapenem-resistant Klebsiella pneumoniae pose a global critical challenge. Understanding the transmission dynamics within and between hospital environments is crucial to develop effective control strategies.MethodsFrom...

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Authors: García-González, N, Beamud, B, Sevilla-Fortuny, J, Sánchez-Hellin, V, Vidal, I, Rodríguez, JC, Fuster, B, Tormo, N, Salvador, C, Gimeno, C, Gomila-Sard, B, Giner, S, Martinez, O, Colomina, J, Navarro, D, Domínguez, V, González-Candelas, F
Format: article
Status:Published version
Publication Date:2025
Country:España
Institution:INCLIVA
Repository:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
OAI Identifier:oai:incliva.fundanetsuite.com:p20676
Online Access:https://incliva.portalinvestigacion.com/publicaciones/20676
Access Level:Open access
Keyword:<italic>Klebsiella pneumoniae</italic>
Carbapenem resistance
Genomic surveillance
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spelling Genomic surveillance reveals different transmission patterns between third-generation cephalosporin and carbapenem resistance in Klebsiella pneumoniae in the Comunidad Valenciana (Spain), 2018-2020García-González, NBeamud, BSevilla-Fortuny, JSánchez-Hellin, VVidal, IRodríguez, JCFuster, BTormo, NSalvador, CGimeno, CGomila-Sard, BGiner, SMartinez, OColomina, JNavarro, DDomínguez, VGonzález-Candelas, F<italic>Klebsiella pneumoniae</italic>Carbapenem resistanceGenomic surveillanceBackgroundThe emergence and spread of third-generation cephalosporins (3GC) and carbapenem-resistant Klebsiella pneumoniae pose a global critical challenge. Understanding the transmission dynamics within and between hospital environments is crucial to develop effective control strategies.MethodsFrom 2017 to 2019, we conducted a genomic surveillance program in eight hospitals of the Comunitat Valenciana, Spain, collecting and sequencing 1,768 3GC- and carbapenem-resistant isolates. We quantified the overall transmission using core genomes and assessed the contribution of national and global isolates to the spread of AMR in the region by including 11,967 database genomes in the analysis.ResultsThe local collection was highly diverse, involving 188 lineages, including global high-risk clones such as ST307 and ST11, and 3GC and carbapenem resistance determinants. Half of the isolates were involved in transmission, with 70.5% occurring within hospitals.ConclusionsDifferent transmission patterns characterized the spread of 3GC- and carbapenem resistance in the region. While inter-hospital transmission played a significant role in the spread of 3GC-resistance, this was only sporadic for carbapenem resistance. Moreover, the factors behind inter-hospital spread for each type of resistance differed: while 3GC-resistance likely disseminated between hospitals through intermediate steps, carbapenem resistance was driven by more direct transmission routes. The burden of national and global cases on the ongoing regional AMR dissemination was low. Moreover, we revealed the rapid expansion in the region and globally of lineage ST307 carrying the blaCTX-M-15 gene, a main driver of local transmissions, providing a deeper understanding of the successful spread of this high-risk clone.BMC2025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://incliva.portalinvestigacion.com/publicaciones/20676Antimicrobial Resistance and Infection ControlISSN: 20472994reponame:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVAinstname:INCLIVAInglésinfo:eu-repo/semantics/openAccessoai:incliva.fundanetsuite.com:p206762026-06-07T16:35:31Z
dc.title.none.fl_str_mv Genomic surveillance reveals different transmission patterns between third-generation cephalosporin and carbapenem resistance in Klebsiella pneumoniae in the Comunidad Valenciana (Spain), 2018-2020
title Genomic surveillance reveals different transmission patterns between third-generation cephalosporin and carbapenem resistance in Klebsiella pneumoniae in the Comunidad Valenciana (Spain), 2018-2020
spellingShingle Genomic surveillance reveals different transmission patterns between third-generation cephalosporin and carbapenem resistance in Klebsiella pneumoniae in the Comunidad Valenciana (Spain), 2018-2020
García-González, N
<italic>Klebsiella pneumoniae</italic>
Carbapenem resistance
Genomic surveillance
title_short Genomic surveillance reveals different transmission patterns between third-generation cephalosporin and carbapenem resistance in Klebsiella pneumoniae in the Comunidad Valenciana (Spain), 2018-2020
title_full Genomic surveillance reveals different transmission patterns between third-generation cephalosporin and carbapenem resistance in Klebsiella pneumoniae in the Comunidad Valenciana (Spain), 2018-2020
title_fullStr Genomic surveillance reveals different transmission patterns between third-generation cephalosporin and carbapenem resistance in Klebsiella pneumoniae in the Comunidad Valenciana (Spain), 2018-2020
title_full_unstemmed Genomic surveillance reveals different transmission patterns between third-generation cephalosporin and carbapenem resistance in Klebsiella pneumoniae in the Comunidad Valenciana (Spain), 2018-2020
title_sort Genomic surveillance reveals different transmission patterns between third-generation cephalosporin and carbapenem resistance in Klebsiella pneumoniae in the Comunidad Valenciana (Spain), 2018-2020
dc.creator.none.fl_str_mv García-González, N
Beamud, B
Sevilla-Fortuny, J
Sánchez-Hellin, V
Vidal, I
Rodríguez, JC
Fuster, B
Tormo, N
Salvador, C
Gimeno, C
Gomila-Sard, B
Giner, S
Martinez, O
Colomina, J
Navarro, D
Domínguez, V
González-Candelas, F
author García-González, N
author_facet García-González, N
Beamud, B
Sevilla-Fortuny, J
Sánchez-Hellin, V
Vidal, I
Rodríguez, JC
Fuster, B
Tormo, N
Salvador, C
Gimeno, C
Gomila-Sard, B
Giner, S
Martinez, O
Colomina, J
Navarro, D
Domínguez, V
González-Candelas, F
author_role author
author2 Beamud, B
Sevilla-Fortuny, J
Sánchez-Hellin, V
Vidal, I
Rodríguez, JC
Fuster, B
Tormo, N
Salvador, C
Gimeno, C
Gomila-Sard, B
Giner, S
Martinez, O
Colomina, J
Navarro, D
Domínguez, V
González-Candelas, F
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv <italic>Klebsiella pneumoniae</italic>
Carbapenem resistance
Genomic surveillance
topic <italic>Klebsiella pneumoniae</italic>
Carbapenem resistance
Genomic surveillance
description BackgroundThe emergence and spread of third-generation cephalosporins (3GC) and carbapenem-resistant Klebsiella pneumoniae pose a global critical challenge. Understanding the transmission dynamics within and between hospital environments is crucial to develop effective control strategies.MethodsFrom 2017 to 2019, we conducted a genomic surveillance program in eight hospitals of the Comunitat Valenciana, Spain, collecting and sequencing 1,768 3GC- and carbapenem-resistant isolates. We quantified the overall transmission using core genomes and assessed the contribution of national and global isolates to the spread of AMR in the region by including 11,967 database genomes in the analysis.ResultsThe local collection was highly diverse, involving 188 lineages, including global high-risk clones such as ST307 and ST11, and 3GC and carbapenem resistance determinants. Half of the isolates were involved in transmission, with 70.5% occurring within hospitals.ConclusionsDifferent transmission patterns characterized the spread of 3GC- and carbapenem resistance in the region. While inter-hospital transmission played a significant role in the spread of 3GC-resistance, this was only sporadic for carbapenem resistance. Moreover, the factors behind inter-hospital spread for each type of resistance differed: while 3GC-resistance likely disseminated between hospitals through intermediate steps, carbapenem resistance was driven by more direct transmission routes. The burden of national and global cases on the ongoing regional AMR dissemination was low. Moreover, we revealed the rapid expansion in the region and globally of lineage ST307 carrying the blaCTX-M-15 gene, a main driver of local transmissions, providing a deeper understanding of the successful spread of this high-risk clone.
publishDate 2025
dc.date.none.fl_str_mv 2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://incliva.portalinvestigacion.com/publicaciones/20676
url https://incliva.portalinvestigacion.com/publicaciones/20676
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv BMC
publisher.none.fl_str_mv BMC
dc.source.none.fl_str_mv Antimicrobial Resistance and Infection Control
ISSN: 20472994
reponame:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
instname:INCLIVA
instname_str INCLIVA
reponame_str r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
collection r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
repository.name.fl_str_mv
repository.mail.fl_str_mv
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