RNA binding protein regulation and cross-talk in the control of AU-rich mRNA fate

mRNA metabolism is tightly orchestrated by highly-regulated RNA Binding Proteins (RBPs) that determine mRNA fate, thereby influencing multiple cellular functions across biological contexts. Here, we review the interplay between six well-known RBPs (TTP, AUF-1, KSRP, HuR, TIA-1, and TIAR) that recogn...

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Detalles Bibliográficos
Autores: García-Mauriño, Sofía M., Rivero-Rodríguez, Francisco, Velázquez-Cruz, Alejandro, Hernández-Vellisca, Marian, Díaz-Quintana, Antonio, Rosa, Miguel A. de la, Díaz-Moreno, Irene
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2017
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/190461
Acceso en línea:http://hdl.handle.net/10261/190461
Access Level:acceso abierto
Palabra clave:Post-transcriptional regulation
Translation
Stability
RNA binding proteins
mRNA fate
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repository_id_str
spelling RNA binding protein regulation and cross-talk in the control of AU-rich mRNA fateGarcía-Mauriño, Sofía M.Rivero-Rodríguez, FranciscoVelázquez-Cruz, AlejandroHernández-Vellisca, MarianDíaz-Quintana, AntonioRosa, Miguel A. de laDíaz-Moreno, IrenePost-transcriptional regulationTranslationStabilityRNA binding proteinsmRNA fatemRNA metabolism is tightly orchestrated by highly-regulated RNA Binding Proteins (RBPs) that determine mRNA fate, thereby influencing multiple cellular functions across biological contexts. Here, we review the interplay between six well-known RBPs (TTP, AUF-1, KSRP, HuR, TIA-1, and TIAR) that recognize AU-rich elements (AREs) at the 3' untranslated regions of mRNAs, namely ARE-RBPs. Examples of the links between their cross-regulations and modulation of their targets are analyzed during mRNA processing, turnover, localization, and translational control. Furthermore, ARE recognition can be self-regulated by several factors that lead to the prevalence of one RBP over another. Consequently, we examine the factors that modulate the dynamics of those protein-RNA transient interactions to better understand the final consequences of the regulation mediated by ARE-RBPs. For instance, factors controlling the RBP isoforms, their conformational state or their post-translational modifications (PTMs) can strongly determine the fate of the protein-RNA complexes. Moreover, mRNA specific sequence and secondary structure or subtle environmental changes are also key determinants to take into account. To sum up, the whole understanding of such a fine tuned regulation is a challenge for future research and requires the integration of all the available structural and functional data by in vivo, in vitro and in silico approaches.Financial support was provided by the Andalusian Government (P11-CVI-7216, BIO198); the Spanish Ministry of Economy, Industry and Competitiveness (BFU2015-71017-P); the Spanish Ministry of Education, Culture and Sports (FPU013/04373, FPU016/01513) and the Ramón Areces Foundation.Peer reviewedFrontiers MediaFundación Ramón ArecesJunta de AndalucíaMinisterio de Educación, Cultura y Deporte (España)Ministerio de Economía y Competitividad (España)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2019201920172019info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/190461reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/BFU2015-71017-Phttps://doi.org/10.3389/fmolb.2017.00071Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/1904612026-05-22T06:33:51Z
dc.title.none.fl_str_mv RNA binding protein regulation and cross-talk in the control of AU-rich mRNA fate
title RNA binding protein regulation and cross-talk in the control of AU-rich mRNA fate
spellingShingle RNA binding protein regulation and cross-talk in the control of AU-rich mRNA fate
García-Mauriño, Sofía M.
Post-transcriptional regulation
Translation
Stability
RNA binding proteins
mRNA fate
title_short RNA binding protein regulation and cross-talk in the control of AU-rich mRNA fate
title_full RNA binding protein regulation and cross-talk in the control of AU-rich mRNA fate
title_fullStr RNA binding protein regulation and cross-talk in the control of AU-rich mRNA fate
title_full_unstemmed RNA binding protein regulation and cross-talk in the control of AU-rich mRNA fate
title_sort RNA binding protein regulation and cross-talk in the control of AU-rich mRNA fate
dc.creator.none.fl_str_mv García-Mauriño, Sofía M.
Rivero-Rodríguez, Francisco
Velázquez-Cruz, Alejandro
Hernández-Vellisca, Marian
Díaz-Quintana, Antonio
Rosa, Miguel A. de la
Díaz-Moreno, Irene
author García-Mauriño, Sofía M.
author_facet García-Mauriño, Sofía M.
Rivero-Rodríguez, Francisco
Velázquez-Cruz, Alejandro
Hernández-Vellisca, Marian
Díaz-Quintana, Antonio
Rosa, Miguel A. de la
Díaz-Moreno, Irene
author_role author
author2 Rivero-Rodríguez, Francisco
Velázquez-Cruz, Alejandro
Hernández-Vellisca, Marian
Díaz-Quintana, Antonio
Rosa, Miguel A. de la
Díaz-Moreno, Irene
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Fundación Ramón Areces
Junta de Andalucía
Ministerio de Educación, Cultura y Deporte (España)
Ministerio de Economía y Competitividad (España)
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Post-transcriptional regulation
Translation
Stability
RNA binding proteins
mRNA fate
topic Post-transcriptional regulation
Translation
Stability
RNA binding proteins
mRNA fate
description mRNA metabolism is tightly orchestrated by highly-regulated RNA Binding Proteins (RBPs) that determine mRNA fate, thereby influencing multiple cellular functions across biological contexts. Here, we review the interplay between six well-known RBPs (TTP, AUF-1, KSRP, HuR, TIA-1, and TIAR) that recognize AU-rich elements (AREs) at the 3' untranslated regions of mRNAs, namely ARE-RBPs. Examples of the links between their cross-regulations and modulation of their targets are analyzed during mRNA processing, turnover, localization, and translational control. Furthermore, ARE recognition can be self-regulated by several factors that lead to the prevalence of one RBP over another. Consequently, we examine the factors that modulate the dynamics of those protein-RNA transient interactions to better understand the final consequences of the regulation mediated by ARE-RBPs. For instance, factors controlling the RBP isoforms, their conformational state or their post-translational modifications (PTMs) can strongly determine the fate of the protein-RNA complexes. Moreover, mRNA specific sequence and secondary structure or subtle environmental changes are also key determinants to take into account. To sum up, the whole understanding of such a fine tuned regulation is a challenge for future research and requires the integration of all the available structural and functional data by in vivo, in vitro and in silico approaches.
publishDate 2017
dc.date.none.fl_str_mv 2017
2019
2019
2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/190461
url http://hdl.handle.net/10261/190461
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/BFU2015-71017-P
https://doi.org/10.3389/fmolb.2017.00071
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,81155

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