Titanium-doped PET nanoplastics, from opaque milk bottle degradation, as a model of environmental true-to-life nanoplastics. Hazardous effects on Drosophila
Micro and nanoplastics (MNPLs) are emergent environmental pollutants, resulting from the degradation of plastic waste, requiring urgent information on their potential risks to human health. To determine such risks, reliable true-to-life materials are essential. In this work, we have used titanium-do...
| Autores: | , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2024 |
| País: | España |
| Institución: | Universitat Autònoma de Barcelona |
| Repositorio: | Dipòsit Digital de Documents de la UAB |
| Idioma: | inglés |
| OAI Identifier: | oai:ddd.uab.cat:287783 |
| Acceso en línea: | https://ddd.uab.cat/record/287783 https://dx.doi.org/urn:doi:10.1016/j.envpol.2023.122968 |
| Access Level: | acceso abierto |
| Palabra clave: | True-to-life nanoplastics Internalization pathway Oxidative stress Gene expression genotoxicity Drosophila melanogaster |
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Titanium-doped PET nanoplastics, from opaque milk bottle degradation, as a model of environmental true-to-life nanoplastics. Hazardous effects on DrosophilaAlaraby, Mohamed|||0000-0001-7488-3318Villacorta, Aliro|||0000-0003-2737-4232Abass, Doaa|||0009-0003-2520-5790Hernández Bonilla, Alba|||0000-0001-6938-1233Marcos Dauder, Ricardo|||0000-0001-7891-357XTrue-to-life nanoplasticsInternalization pathwayOxidative stressGene expression genotoxicityDrosophila melanogasterMicro and nanoplastics (MNPLs) are emergent environmental pollutants, resulting from the degradation of plastic waste, requiring urgent information on their potential risks to human health. To determine such risks, reliable true-to-life materials are essential. In this work, we have used titanium-doped PET NPLs [PET(Ti)NPLs], obtained by grinding opaque milk polyethylene terephthalate (PET) bottles, as a true-to-life MNPLs model. These opaque PET bottles, with an average size of 112 nm, contain about 3% Ti in the form of titanium dioxide rod nanoparticles. TEM investigation confirmed the mixed Ti/PET nature of the obtained true-to-life NPLs, and the rod shape of the embedded TiONPs. In the in vivo Drosophila model neither PET(Ti)NPLs nor TiONPs reduced the survival rates, although their internalization was confirmed in different compartments of the larval body by using confocal and transmission electron microscopies. The presence of Ti in the PET(Ti)NPLs permitted to quantify its presence both in larvae (2.1 ± 2.2 μg/g of Ti) and in the resulting adults (3.4 ± 3.2 μg/g of Ti) after treatment with 500 μg/g food of PET(Ti)NPL, suggesting its potential use to track their fate in more complex organisms such as mammals. PET(Ti)NPLs, as well as TiONPs, altered the expression of genes driving different response pathways, inducing significant oxidative stress levels (up to 10 folds), and genotoxicity. This last result on the genotoxic effects is remarkable in the frame of the hot topic discussion on the risk that titanium compounds, used as food additives, may pose to humans. 22024-01-0120242024-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/287783https://dx.doi.org/urn:doi:10.1016/j.envpol.2023.122968reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengEuropean Commission https://doi.org/10.13039/501100000780 965196Agencia Estatal de Investigación https://doi.org/10.13039/501100011033 PID2020-116789RB-C43Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2021/SGR-00731open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2877832026-06-06T12:50:31Z |
| dc.title.none.fl_str_mv |
Titanium-doped PET nanoplastics, from opaque milk bottle degradation, as a model of environmental true-to-life nanoplastics. Hazardous effects on Drosophila |
| title |
Titanium-doped PET nanoplastics, from opaque milk bottle degradation, as a model of environmental true-to-life nanoplastics. Hazardous effects on Drosophila |
| spellingShingle |
Titanium-doped PET nanoplastics, from opaque milk bottle degradation, as a model of environmental true-to-life nanoplastics. Hazardous effects on Drosophila Alaraby, Mohamed|||0000-0001-7488-3318 True-to-life nanoplastics Internalization pathway Oxidative stress Gene expression genotoxicity Drosophila melanogaster |
| title_short |
Titanium-doped PET nanoplastics, from opaque milk bottle degradation, as a model of environmental true-to-life nanoplastics. Hazardous effects on Drosophila |
| title_full |
Titanium-doped PET nanoplastics, from opaque milk bottle degradation, as a model of environmental true-to-life nanoplastics. Hazardous effects on Drosophila |
| title_fullStr |
Titanium-doped PET nanoplastics, from opaque milk bottle degradation, as a model of environmental true-to-life nanoplastics. Hazardous effects on Drosophila |
| title_full_unstemmed |
Titanium-doped PET nanoplastics, from opaque milk bottle degradation, as a model of environmental true-to-life nanoplastics. Hazardous effects on Drosophila |
| title_sort |
Titanium-doped PET nanoplastics, from opaque milk bottle degradation, as a model of environmental true-to-life nanoplastics. Hazardous effects on Drosophila |
| dc.creator.none.fl_str_mv |
Alaraby, Mohamed|||0000-0001-7488-3318 Villacorta, Aliro|||0000-0003-2737-4232 Abass, Doaa|||0009-0003-2520-5790 Hernández Bonilla, Alba|||0000-0001-6938-1233 Marcos Dauder, Ricardo|||0000-0001-7891-357X |
| author |
Alaraby, Mohamed|||0000-0001-7488-3318 |
| author_facet |
Alaraby, Mohamed|||0000-0001-7488-3318 Villacorta, Aliro|||0000-0003-2737-4232 Abass, Doaa|||0009-0003-2520-5790 Hernández Bonilla, Alba|||0000-0001-6938-1233 Marcos Dauder, Ricardo|||0000-0001-7891-357X |
| author_role |
author |
| author2 |
Villacorta, Aliro|||0000-0003-2737-4232 Abass, Doaa|||0009-0003-2520-5790 Hernández Bonilla, Alba|||0000-0001-6938-1233 Marcos Dauder, Ricardo|||0000-0001-7891-357X |
| author2_role |
author author author author |
| dc.subject.none.fl_str_mv |
True-to-life nanoplastics Internalization pathway Oxidative stress Gene expression genotoxicity Drosophila melanogaster |
| topic |
True-to-life nanoplastics Internalization pathway Oxidative stress Gene expression genotoxicity Drosophila melanogaster |
| description |
Micro and nanoplastics (MNPLs) are emergent environmental pollutants, resulting from the degradation of plastic waste, requiring urgent information on their potential risks to human health. To determine such risks, reliable true-to-life materials are essential. In this work, we have used titanium-doped PET NPLs [PET(Ti)NPLs], obtained by grinding opaque milk polyethylene terephthalate (PET) bottles, as a true-to-life MNPLs model. These opaque PET bottles, with an average size of 112 nm, contain about 3% Ti in the form of titanium dioxide rod nanoparticles. TEM investigation confirmed the mixed Ti/PET nature of the obtained true-to-life NPLs, and the rod shape of the embedded TiONPs. In the in vivo Drosophila model neither PET(Ti)NPLs nor TiONPs reduced the survival rates, although their internalization was confirmed in different compartments of the larval body by using confocal and transmission electron microscopies. The presence of Ti in the PET(Ti)NPLs permitted to quantify its presence both in larvae (2.1 ± 2.2 μg/g of Ti) and in the resulting adults (3.4 ± 3.2 μg/g of Ti) after treatment with 500 μg/g food of PET(Ti)NPL, suggesting its potential use to track their fate in more complex organisms such as mammals. PET(Ti)NPLs, as well as TiONPs, altered the expression of genes driving different response pathways, inducing significant oxidative stress levels (up to 10 folds), and genotoxicity. This last result on the genotoxic effects is remarkable in the frame of the hot topic discussion on the risk that titanium compounds, used as food additives, may pose to humans. |
| publishDate |
2024 |
| dc.date.none.fl_str_mv |
2 2024-01-01 2024 2024-01-01 |
| dc.type.none.fl_str_mv |
Article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
https://ddd.uab.cat/record/287783 https://dx.doi.org/urn:doi:10.1016/j.envpol.2023.122968 |
| url |
https://ddd.uab.cat/record/287783 https://dx.doi.org/urn:doi:10.1016/j.envpol.2023.122968 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.relation.none.fl_str_mv |
European Commission https://doi.org/10.13039/501100000780 965196 Agencia Estatal de Investigación https://doi.org/10.13039/501100011033 PID2020-116789RB-C43 Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2021/SGR-00731 |
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open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
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openAccess |
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application/pdf |
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