Low n-6/n-3 gestation and lactation diets influence early performance, muscle and adipose polyunsaturated fatty acid content and deposition, and relative abundance of proteins in suckling piglets

This article belongs to the Special Issue Omics Analysis in Veterinary Medicine and Animal Science.

Detalhes bibliográficos
Autores: Manaig, Yron Joseph Yabut, Sandrini, Silvia, Panseri, Sara, Tedeschi, Gabriella, Folch, Josep María, Sánchez, Armand, Savoini, Giovanni, Agazzi, Alessandro
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/279741
Acesso em linha:http://hdl.handle.net/10261/279741
Access Level:acceso abierto
Palavra-chave:Piglets
Fat deposition
Longissimus dorsi
Inflammation
Adipose tissue
Omega-3
PUFA
Proteomics
Omega-6
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spelling Low n-6/n-3 gestation and lactation diets influence early performance, muscle and adipose polyunsaturated fatty acid content and deposition, and relative abundance of proteins in suckling pigletsManaig, Yron Joseph YabutSandrini, SilviaPanseri, SaraTedeschi, GabriellaFolch, Josep MaríaSánchez, ArmandSavoini, GiovanniAgazzi, AlessandroPigletsFat depositionLongissimus dorsiInflammationAdipose tissueOmega-3PUFAProteomicsOmega-6This article belongs to the Special Issue Omics Analysis in Veterinary Medicine and Animal Science.Elevated omega-6 (n-6) and omega-3 (n-3) polyunsaturated fatty acids (PUFAs) ratios in swine diets can potentially impose a higher risk of inflammatory and metabolic diseases in swine. A low ratio between the two omega PUFAs has beneficial effects on sows’ and piglets’ production performance and immunity status. At present, there are few studies on how sow nutrition directly affects the protein and fat deposition in suckling piglets. Two groups of sows were fed diets with high or low n-6/n-3 polyunsaturated ratios of 13:1 (SOY) and 4:1 (LIN), respectively, during gestation and lactation. Longissimus dorsi muscle and adipose tissue from newborn piglets, nourished only with sow’s milk, were subjected to fatty acid profiling by gas chromatography–mass spectrometry (GC-MS) and to proteomics assays based on nano-liquid chromatography coupled to high-resolution tandem mass spectrometry (nLC-HRMS). Fatty acid profiles on both muscle and adipose tissues resembled the magnitude of the differences between fatty acid across diets. Proteomic analysis revealed overabundance of 4 muscle and 11 adipose tissue proteins in SOY compared to LIN in both piglet tissues. The detected overabundance of haptoglobin, an acute-phase protein, and the stimulation of protein-coding genes and proteins related to the innate immune response and acute inflammatory response could be associated with the pro-inflammatory role of n-6 PUFAs.This project has received funding from the European Union’s Horizon 2020 research and innovation programme H2020-MSCA-ITN-2017-EJD under the Marie Skłodowska-Curie Innovative Training Networks (European Joint Doctorate in Molecular Animal Nutrition, MANNA), grant agreement No 765423. More information can be found at www.phd4manna.eu, accessed on 21 March 2022.Peer reviewedMultidisciplinary Digital Publishing InstituteEuropean CommissionEuropean Research CouncilConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202220222022info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/279741reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/EC/H2020/765423The underlying dataset has been published as supplementary material in the publisher platform at 10.3390/molecules27092925https://doi.org/10.3390/molecules27092925Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2797412026-05-22T06:33:51Z
dc.title.none.fl_str_mv Low n-6/n-3 gestation and lactation diets influence early performance, muscle and adipose polyunsaturated fatty acid content and deposition, and relative abundance of proteins in suckling piglets
title Low n-6/n-3 gestation and lactation diets influence early performance, muscle and adipose polyunsaturated fatty acid content and deposition, and relative abundance of proteins in suckling piglets
spellingShingle Low n-6/n-3 gestation and lactation diets influence early performance, muscle and adipose polyunsaturated fatty acid content and deposition, and relative abundance of proteins in suckling piglets
Manaig, Yron Joseph Yabut
Piglets
Fat deposition
Longissimus dorsi
Inflammation
Adipose tissue
Omega-3
PUFA
Proteomics
Omega-6
title_short Low n-6/n-3 gestation and lactation diets influence early performance, muscle and adipose polyunsaturated fatty acid content and deposition, and relative abundance of proteins in suckling piglets
title_full Low n-6/n-3 gestation and lactation diets influence early performance, muscle and adipose polyunsaturated fatty acid content and deposition, and relative abundance of proteins in suckling piglets
title_fullStr Low n-6/n-3 gestation and lactation diets influence early performance, muscle and adipose polyunsaturated fatty acid content and deposition, and relative abundance of proteins in suckling piglets
title_full_unstemmed Low n-6/n-3 gestation and lactation diets influence early performance, muscle and adipose polyunsaturated fatty acid content and deposition, and relative abundance of proteins in suckling piglets
title_sort Low n-6/n-3 gestation and lactation diets influence early performance, muscle and adipose polyunsaturated fatty acid content and deposition, and relative abundance of proteins in suckling piglets
dc.creator.none.fl_str_mv Manaig, Yron Joseph Yabut
Sandrini, Silvia
Panseri, Sara
Tedeschi, Gabriella
Folch, Josep María
Sánchez, Armand
Savoini, Giovanni
Agazzi, Alessandro
author Manaig, Yron Joseph Yabut
author_facet Manaig, Yron Joseph Yabut
Sandrini, Silvia
Panseri, Sara
Tedeschi, Gabriella
Folch, Josep María
Sánchez, Armand
Savoini, Giovanni
Agazzi, Alessandro
author_role author
author2 Sandrini, Silvia
Panseri, Sara
Tedeschi, Gabriella
Folch, Josep María
Sánchez, Armand
Savoini, Giovanni
Agazzi, Alessandro
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv European Commission
European Research Council
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Piglets
Fat deposition
Longissimus dorsi
Inflammation
Adipose tissue
Omega-3
PUFA
Proteomics
Omega-6
topic Piglets
Fat deposition
Longissimus dorsi
Inflammation
Adipose tissue
Omega-3
PUFA
Proteomics
Omega-6
description This article belongs to the Special Issue Omics Analysis in Veterinary Medicine and Animal Science.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/279741
url http://hdl.handle.net/10261/279741
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/EC/H2020/765423
The underlying dataset has been published as supplementary material in the publisher platform at 10.3390/molecules27092925
https://doi.org/10.3390/molecules27092925
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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