Total carotene plasma concentrations are inversely associated with atherosclerotic plaque burden: A post-hoc analysis of the DIABIMCAP cohort

Background and aims: Atherosclerosis is the major risk factor for cardiovascular disease (CVD), the first cause of death worldwide. Chronic low-grade inflammation and a sustained oxidative milieu are caus- atively related to atherosclerosis onset and progression, and therefore, dietary patterns rich...

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Autores: Bujosa, Francesc, Herreras, Zoe, Catalan, Marta, Pinyol, Montse, Lamuela-Raventos, Rosa M, Martínez-Huélamo, Miriam, Gilabert, Rosa, Jimenez, Amanda, Ortega Martinez de Victoria, Emilio, Chiva-Blanch, Gemma
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Universitat Oberta de Catalunya (UOC)
Repositorio:O2, repositorio institucional de la UOC
OAI Identifier:oai:openaccess.uoc.edu:10609/148608
Acceso en línea:http://hdl.handle.net/10609/148608
https://doi.org/10.1016/j.clnu.2023.05.005
Access Level:acceso abierto
Palabra clave:carotenes
mediterranean diet
fruit and vegetables
atherosclerosis
plaque burden
intima media thickness
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spelling Total carotene plasma concentrations are inversely associated with atherosclerotic plaque burden: A post-hoc analysis of the DIABIMCAP cohortBujosa, FrancescHerreras, ZoeCatalan, MartaPinyol, MontseLamuela-Raventos, Rosa MMartínez-Huélamo, MiriamGilabert, RosaJimenez, AmandaOrtega Martinez de Victoria, EmilioChiva-Blanch, Gemmacarotenesmediterranean dietfruit and vegetablesatherosclerosisplaque burdenintima media thicknessBackground and aims: Atherosclerosis is the major risk factor for cardiovascular disease (CVD), the first cause of death worldwide. Chronic low-grade inflammation and a sustained oxidative milieu are caus- atively related to atherosclerosis onset and progression, and therefore, dietary patterns rich in bioactive compounds with anti-inflammatory and antioxidant activities might likely contribute to revert or slowing the progression of atherosclerosis. The aim of this study is to analyse the association between fruit and vegetables intake, quantitatively measured through carotene plasma concentrations, and atherosclerotic burden, as a surrogate biomarker of CVD, in free-living subjects from the DIABIMCAP cohort study. Methods: The 204 participants of the DIABIMCAP Study cohort (Carotid Atherosclerosis in Newly Diag- nosed Type 2 Diabetic Individuals, ClinicalTrials.gov Identifier: NCT01898572), were included in this cross-sectional study. Total, a-, and b-carotenes were quantified by HPLC-MS/MS. Lipoprotein analysis in serum was performed by 2D- 1H NMR- DOSY, and atherosclerosis and intima media thickness (IMT) were measured through standardized bilateral carotid artery ultrasound imaging. Results: Subjects with atherosclerosis (n 1⁄4 134) had lower levels of large HDL particles than subjects without atherosclerosis. Positive associations were found between a-carotene and both large and me- dium HDL particles, and inverse associations were found between b- and total carotene, and VLDL and its medium/small particles. Subjects with atherosclerosis presented significantly lower plasma concentra- tions of total carotene compared with subjects without atherosclerosis. Plasma concentrations of caro- tene decreased as the number of atherosclerotic plaques increased, although after multivariate adjustment, the inverse association between b- and total carotene with plaque burden remained sig- nificant only in women.Elsevier202320232023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10609/148608https://doi.org/10.1016/j.clnu.2023.05.005reponame:O2, repositorio institucional de la UOCinstname:Universitat Oberta de Catalunya (UOC)InglésClinical Nutrition, 2023, 42, pp 1168e1174https://www.clinicalnutritionjournal.com/article/S0261-5614(23)00147-4/fulltext#articleInformationCC BYhttps://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:openaccess.uoc.edu:10609/1486082026-05-28T12:42:01Z
dc.title.none.fl_str_mv Total carotene plasma concentrations are inversely associated with atherosclerotic plaque burden: A post-hoc analysis of the DIABIMCAP cohort
title Total carotene plasma concentrations are inversely associated with atherosclerotic plaque burden: A post-hoc analysis of the DIABIMCAP cohort
spellingShingle Total carotene plasma concentrations are inversely associated with atherosclerotic plaque burden: A post-hoc analysis of the DIABIMCAP cohort
Bujosa, Francesc
carotenes
mediterranean diet
fruit and vegetables
atherosclerosis
plaque burden
intima media thickness
title_short Total carotene plasma concentrations are inversely associated with atherosclerotic plaque burden: A post-hoc analysis of the DIABIMCAP cohort
title_full Total carotene plasma concentrations are inversely associated with atherosclerotic plaque burden: A post-hoc analysis of the DIABIMCAP cohort
title_fullStr Total carotene plasma concentrations are inversely associated with atherosclerotic plaque burden: A post-hoc analysis of the DIABIMCAP cohort
title_full_unstemmed Total carotene plasma concentrations are inversely associated with atherosclerotic plaque burden: A post-hoc analysis of the DIABIMCAP cohort
title_sort Total carotene plasma concentrations are inversely associated with atherosclerotic plaque burden: A post-hoc analysis of the DIABIMCAP cohort
dc.creator.none.fl_str_mv Bujosa, Francesc
Herreras, Zoe
Catalan, Marta
Pinyol, Montse
Lamuela-Raventos, Rosa M
Martínez-Huélamo, Miriam
Gilabert, Rosa
Jimenez, Amanda
Ortega Martinez de Victoria, Emilio
Chiva-Blanch, Gemma
author Bujosa, Francesc
author_facet Bujosa, Francesc
Herreras, Zoe
Catalan, Marta
Pinyol, Montse
Lamuela-Raventos, Rosa M
Martínez-Huélamo, Miriam
Gilabert, Rosa
Jimenez, Amanda
Ortega Martinez de Victoria, Emilio
Chiva-Blanch, Gemma
author_role author
author2 Herreras, Zoe
Catalan, Marta
Pinyol, Montse
Lamuela-Raventos, Rosa M
Martínez-Huélamo, Miriam
Gilabert, Rosa
Jimenez, Amanda
Ortega Martinez de Victoria, Emilio
Chiva-Blanch, Gemma
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv carotenes
mediterranean diet
fruit and vegetables
atherosclerosis
plaque burden
intima media thickness
topic carotenes
mediterranean diet
fruit and vegetables
atherosclerosis
plaque burden
intima media thickness
description Background and aims: Atherosclerosis is the major risk factor for cardiovascular disease (CVD), the first cause of death worldwide. Chronic low-grade inflammation and a sustained oxidative milieu are caus- atively related to atherosclerosis onset and progression, and therefore, dietary patterns rich in bioactive compounds with anti-inflammatory and antioxidant activities might likely contribute to revert or slowing the progression of atherosclerosis. The aim of this study is to analyse the association between fruit and vegetables intake, quantitatively measured through carotene plasma concentrations, and atherosclerotic burden, as a surrogate biomarker of CVD, in free-living subjects from the DIABIMCAP cohort study. Methods: The 204 participants of the DIABIMCAP Study cohort (Carotid Atherosclerosis in Newly Diag- nosed Type 2 Diabetic Individuals, ClinicalTrials.gov Identifier: NCT01898572), were included in this cross-sectional study. Total, a-, and b-carotenes were quantified by HPLC-MS/MS. Lipoprotein analysis in serum was performed by 2D- 1H NMR- DOSY, and atherosclerosis and intima media thickness (IMT) were measured through standardized bilateral carotid artery ultrasound imaging. Results: Subjects with atherosclerosis (n 1⁄4 134) had lower levels of large HDL particles than subjects without atherosclerosis. Positive associations were found between a-carotene and both large and me- dium HDL particles, and inverse associations were found between b- and total carotene, and VLDL and its medium/small particles. Subjects with atherosclerosis presented significantly lower plasma concentra- tions of total carotene compared with subjects without atherosclerosis. Plasma concentrations of caro- tene decreased as the number of atherosclerotic plaques increased, although after multivariate adjustment, the inverse association between b- and total carotene with plaque burden remained sig- nificant only in women.
publishDate 2023
dc.date.none.fl_str_mv 2023
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10609/148608
https://doi.org/10.1016/j.clnu.2023.05.005
url http://hdl.handle.net/10609/148608
https://doi.org/10.1016/j.clnu.2023.05.005
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Clinical Nutrition, 2023, 42, pp 1168e1174
https://www.clinicalnutritionjournal.com/article/S0261-5614(23)00147-4/fulltext#articleInformation
dc.rights.none.fl_str_mv CC BY
https://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv CC BY
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:O2, repositorio institucional de la UOC
instname:Universitat Oberta de Catalunya (UOC)
instname_str Universitat Oberta de Catalunya (UOC)
reponame_str O2, repositorio institucional de la UOC
collection O2, repositorio institucional de la UOC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301603

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