A fast imaging Mueller matrix polarimeter for biomedical applications
A Mueller Matrix Polarimeter is a device that measures the Mueller matrix of a sample, giving quantitative information on the change in the state of polarization light upon interaction with the sample. It measures the Mueller matrix of the field of view and thus allows visualization of the objects p...
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| Tipo de recurso: | tesis de maestría |
| Fecha de publicación: | 2022 |
| País: | España |
| Institución: | Universitat Politècnica de Catalunya (UPC) |
| Repositorio: | UPCommons. Portal del coneixement obert de la UPC |
| Idioma: | inglés |
| OAI Identifier: | oai:upcommons.upc.edu:2117/388292 |
| Acceso en línea: | https://hdl.handle.net/2117/388292 |
| Access Level: | acceso abierto |
| Palabra clave: | Ellipsometry Polarization (Light) Mueller Matrix Imaging Polarimetry Biomedical Imaging El·lipsometria Polarització (Llum) Àrees temàtiques de la UPC::Enginyeria de la telecomunicació::Telecomunicació òptica |
| Sumario: | A Mueller Matrix Polarimeter is a device that measures the Mueller matrix of a sample, giving quantitative information on the change in the state of polarization light upon interaction with the sample. It measures the Mueller matrix of the field of view and thus allows visualization of the objects polarization properties. It gives the transfer function of an optical system interacting with polarized light by containing all the necessary information about the linear optical properties of the medium. Nowadays, Mueller matrix polarimetry is increasingly used in the biomedical field to obtain microstructural information on biological samples such as tissues. Interest in these devices is growing in fields ranging from physics to biological sciences because of the technique's ability to detect specific abnormalities in tissue, such as cancer growth, that may interact differently with polarized light. When light interacts with biological tissue, its polarization direction is mainly changed by multiple scattering of photons and local anisotropy of the tissue. As a result, analyzing a polarimetric image can provide information about the organization of the different layers that make up the sample or their structure and thickness. This work describes the construction and performance of a fast-imaging Mueller matrix polarimeter operating in the visible and near-infrared spectral ranges. Here, we will present an instrument that operates in reflection and is close to normal incidence (back-scattering configuration). This is highly desirable for biomedical applications because the sample does not need to be partially transparent for the detector to collect the required amount of light, as occurs in the transmission configuration. Our instrument targets very fast measurement compatible with in-vivo applications, and the whole Mueller matrix of the sample is measured within 2.5 seconds. |
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