How has the aspergillosis case fatality rate changed over the last two decades in Spain?

(1) Background: Aspergillus produces high morbidity and mortality, especially in at-risk populations. In Spain, the evolution of mortality in recent years due to this fungus is not well established. The aim of this study was to estimate the case fatality rate of aspergillosis in inpatients from 1997...

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Autores: González García, Pablo, Alonso-Sardón, Montserrat, Rodríguez-Alonso, Beatriz, Almeida, Hugo, Romero-Alegría, Ángela, Vega-Rodríguez, Víctor-José, López-Bernús, Amparo, Muñoz-Bellido, Juan Luis, Muro, Antonio, Pardo Lledías, Javier, Belhassen García, Moncef
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Universidad de Cantabria (UC)
Repositorio:UCrea Repositorio Abierto de la Universidad de Cantabria
Idioma:inglés
OAI Identifier:oai:repositorio.unican.es:10902/29065
Acceso en línea:https://hdl.handle.net/10902/29065
Access Level:acceso abierto
Palabra clave:Aspergillosis
Human aspergillosis
Invasive fungal diseases
Case fatality rate
Spain
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spelling How has the aspergillosis case fatality rate changed over the last two decades in Spain?González García, PabloAlonso-Sardón, MontserratRodríguez-Alonso, BeatrizAlmeida, HugoRomero-Alegría, ÁngelaVega-Rodríguez, Víctor-JoséLópez-Bernús, AmparoMuñoz-Bellido, Juan LuisMuro, AntonioPardo Lledías, JavierBelhassen García, MoncefAspergillosisHuman aspergillosisInvasive fungal diseasesCase fatality rateSpain(1) Background: Aspergillus produces high morbidity and mortality, especially in at-risk populations. In Spain, the evolution of mortality in recent years due to this fungus is not well established. The aim of this study was to estimate the case fatality rate of aspergillosis in inpatients from 1997 to 2017 in Spain. (2) Methodology: A retrospective descriptive study was conducted with records of inpatients admitted to the National Health System with a diagnosis of aspergillosis. (3) Principal findings: Of 32,960 aspergillosis inpatients, 24.5% of deaths were registered, and 71% of the patients who died were men. The percentage of deaths increased progressively with age. The case fatality rate progressively decreased over the period, from 25.4 and 27.8% in 1997-1998 to values of 20.6 and 20.8% in 2016 and 2017. Influenza and pneumonia occurrence/association significantly increased case fatality rates in all cases. (4) Conclusions: Our study shows that lethality significantly decreased in the last two decades despite the increase in cases. This highlights the fact that patients with solid and/or hematological cancer do not have a much higher mortality rate than the group of patients with pneumonia or influenza alone, these two factors being the ones that cause the highest CFRs. We also need studies that analyze the causes of mortality to decrease it and studies that evaluate the impact of COVID-19.Multidisciplinary Digital Publishing Institute (MDPI)Universidad de Cantabria20222022-05-27journal articlehttp://purl.org/coar/resource_type/c_6501NAhttp://purl.org/coar/version/c_be7fb7dd8ff6fe43info:eu-repo/semantics/articlehttps://hdl.handle.net/10902/29065Journal of Fungi, 2022, 8, 576.reponame:UCrea Repositorio Abierto de la Universidad de Cantabriainstname:Universidad de Cantabria (UC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repositorio.unican.es:10902/290652026-06-02T12:39:31Z
dc.title.none.fl_str_mv How has the aspergillosis case fatality rate changed over the last two decades in Spain?
title How has the aspergillosis case fatality rate changed over the last two decades in Spain?
spellingShingle How has the aspergillosis case fatality rate changed over the last two decades in Spain?
González García, Pablo
Aspergillosis
Human aspergillosis
Invasive fungal diseases
Case fatality rate
Spain
title_short How has the aspergillosis case fatality rate changed over the last two decades in Spain?
title_full How has the aspergillosis case fatality rate changed over the last two decades in Spain?
title_fullStr How has the aspergillosis case fatality rate changed over the last two decades in Spain?
title_full_unstemmed How has the aspergillosis case fatality rate changed over the last two decades in Spain?
title_sort How has the aspergillosis case fatality rate changed over the last two decades in Spain?
dc.creator.none.fl_str_mv González García, Pablo
Alonso-Sardón, Montserrat
Rodríguez-Alonso, Beatriz
Almeida, Hugo
Romero-Alegría, Ángela
Vega-Rodríguez, Víctor-José
López-Bernús, Amparo
Muñoz-Bellido, Juan Luis
Muro, Antonio
Pardo Lledías, Javier
Belhassen García, Moncef
author González García, Pablo
author_facet González García, Pablo
Alonso-Sardón, Montserrat
Rodríguez-Alonso, Beatriz
Almeida, Hugo
Romero-Alegría, Ángela
Vega-Rodríguez, Víctor-José
López-Bernús, Amparo
Muñoz-Bellido, Juan Luis
Muro, Antonio
Pardo Lledías, Javier
Belhassen García, Moncef
author_role author
author2 Alonso-Sardón, Montserrat
Rodríguez-Alonso, Beatriz
Almeida, Hugo
Romero-Alegría, Ángela
Vega-Rodríguez, Víctor-José
López-Bernús, Amparo
Muñoz-Bellido, Juan Luis
Muro, Antonio
Pardo Lledías, Javier
Belhassen García, Moncef
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad de Cantabria
dc.subject.none.fl_str_mv Aspergillosis
Human aspergillosis
Invasive fungal diseases
Case fatality rate
Spain
topic Aspergillosis
Human aspergillosis
Invasive fungal diseases
Case fatality rate
Spain
description (1) Background: Aspergillus produces high morbidity and mortality, especially in at-risk populations. In Spain, the evolution of mortality in recent years due to this fungus is not well established. The aim of this study was to estimate the case fatality rate of aspergillosis in inpatients from 1997 to 2017 in Spain. (2) Methodology: A retrospective descriptive study was conducted with records of inpatients admitted to the National Health System with a diagnosis of aspergillosis. (3) Principal findings: Of 32,960 aspergillosis inpatients, 24.5% of deaths were registered, and 71% of the patients who died were men. The percentage of deaths increased progressively with age. The case fatality rate progressively decreased over the period, from 25.4 and 27.8% in 1997-1998 to values of 20.6 and 20.8% in 2016 and 2017. Influenza and pneumonia occurrence/association significantly increased case fatality rates in all cases. (4) Conclusions: Our study shows that lethality significantly decreased in the last two decades despite the increase in cases. This highlights the fact that patients with solid and/or hematological cancer do not have a much higher mortality rate than the group of patients with pneumonia or influenza alone, these two factors being the ones that cause the highest CFRs. We also need studies that analyze the causes of mortality to decrease it and studies that evaluate the impact of COVID-19.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022-05-27
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
NA
http://purl.org/coar/version/c_be7fb7dd8ff6fe43
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/10902/29065
url https://hdl.handle.net/10902/29065
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute (MDPI)
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute (MDPI)
dc.source.none.fl_str_mv Journal of Fungi, 2022, 8, 576.
reponame:UCrea Repositorio Abierto de la Universidad de Cantabria
instname:Universidad de Cantabria (UC)
instname_str Universidad de Cantabria (UC)
reponame_str UCrea Repositorio Abierto de la Universidad de Cantabria
collection UCrea Repositorio Abierto de la Universidad de Cantabria
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.301603

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