Pancreatic cancer markers based on aberrant glycosylation of serum proteins
Cancer is one of the leading causes of death worldwide. Pancreatic ductal adenocarcinoma (PDAC) is characterized by high intrinsic aggressiveness and late diagnosis, causing poor prognosis and resulting in the lowest five-year survival rate among all cancers. Nowadays, there is no biomarker for PDAC...
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| Tipo de recurso: | tesis doctoral |
| Estado: | Versión publicada |
| Fecha de publicación: | 2016 |
| País: | España |
| Institución: | CBUC, CESCA |
| Repositorio: | TDR. Tesis Doctorales en Red |
| OAI Identifier: | oai:www.tdx.cat:10803/392636 |
| Acceso en línea: | http://hdl.handle.net/10803/392636 |
| Access Level: | acceso abierto |
| Palabra clave: | Pancreatic cancer Càncer de pàncrees Cáncer de páncreas Tumour markers Marcadors tumorals Marcadores tumorales Pancreatic ductal adenocarcinoma Adenocarcinoma ductal pancreàtic Adenocarcinoma ductal pancreático Glycosilation Glicosilació Glicosilación Serum glycoproteins Glicoproteïnes sèriques Glicoproteínas séricas Mucins Mucines Mucinas 577 616 |
| Sumario: | Cancer is one of the leading causes of death worldwide. Pancreatic ductal adenocarcinoma (PDAC) is characterized by high intrinsic aggressiveness and late diagnosis, causing poor prognosis and resulting in the lowest five-year survival rate among all cancers. Nowadays, there is no biomarker for PDAC diagnosis approved. The survival rate of cancer patients increases when they are diagnosed in the early stages of the pathology; and for this reason, the research of new biomarkers is of great interest. Tumour cells present aberrant glycosylation on their cell surface and also in the secreted glycoconjugates. Hence, a strategy for new tumour biomarker discovery is based on the identification of specific glycoforms. This work has explored the glycosylation of two serum glycoproteins, the alpha-1-acid glycoprotein (AGP) and the ceruloplasmin (CP). The glycosylation of the epithelial mucins MUC1 and MUC5AC in healthy and PDAC tissues has also been analysed. |
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