The dynamics of human cognition: increasing global integration coupled with decreasing segregation found using iEEG
Cognitive processing requires the ability to flexibly integrate and process information across large brain networks. How do brain networks dynamically reorganize to allow broad communication between many different brain regions in order to integrate information? We record neural activity from 12 epi...
| Autores: | , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión aceptada para publicación |
| Fecha de publicación: | 2018 |
| País: | España |
| Institución: | Universitat Pompeu Fabra |
| Repositorio: | Repositorio Digital de la UPF |
| OAI Identifier: | oai:repositori.upf.edu:10230/47938 |
| Acceso en línea: | http://hdl.handle.net/10230/47938 http://dx.doi.org/10.1016/j.neuroimage.2018.01.064 |
| Access Level: | acceso abierto |
| Palabra clave: | Segregation Integration CTC theory Cognition iEEG |
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The dynamics of human cognition: increasing global integration coupled with decreasing segregation found using iEEGCruzat Grand, Josefina, 1983-Deco, GustavoTauste Campo, Adrià, 1982-Principe, AlessandroCosta, Albert, 1970-Kringelbach, Morten L.Rocamora Zúñiga, Rodrigo AlbertoSegregationIntegrationCTC theoryCognitioniEEGCognitive processing requires the ability to flexibly integrate and process information across large brain networks. How do brain networks dynamically reorganize to allow broad communication between many different brain regions in order to integrate information? We record neural activity from 12 epileptic patients using intracranial EEG while performing three cognitive tasks. We assess how the functional connectivity between different brain areas changes to facilitate communication across them. At the topological level, this facilitation is characterized by measures of integration and segregation. Across all patients, we found significant increases in integration and decreases in segregation during cognitive processing, especially in the gamma band (50–90 Hz). We also found higher levels of global synchronization and functional connectivity during task execution, again particularly in the gamma band. More importantly, functional connectivity modulations were not caused by changes in the level of the underlying oscillations. Instead, these modulations were caused by a rearrangement of the mutual synchronization between the different nodes as proposed by the “Communication Through Coherence” Theory.The authors would like to thank all patients for their participation and the IMIM-Hospital del Mar Epilepsy Unit staff for their technical assistance in collecting the data. This work was supported by Gustavo Deco's ERC Advanced Grant: DYSTRUCTURE (n. 295129), from the European Union's Horizon 2020 research and innovation programme under grant agreement No. (HBP SGA1) and by the Spanish Research Project PSI2013-42091-P. M.L.K. is supported by the ERC Consolidator Grant CAREGIVING (n. 615539) and the Center for Music in the Brain, funded by the Danish National Research Foundation (DNRF117).Elsevier202120212018info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/47938http://dx.doi.org/10.1016/j.neuroimage.2018.01.064reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésNeuroimage. 2018 May 15;172:492-505info:eu-repo/grantAgreement/EC/H2020/295129info:eu-repo/grantAgreement/ES/1PE/PSI2013-42091-Pinfo:eu-repo/grantAgreement/EC/FP7/615539© Elsevier http://dx.doi.org/10.1016/j.neuroimage.2018.01.064info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/479382026-06-12T07:21:37Z |
| dc.title.none.fl_str_mv |
The dynamics of human cognition: increasing global integration coupled with decreasing segregation found using iEEG |
| title |
The dynamics of human cognition: increasing global integration coupled with decreasing segregation found using iEEG |
| spellingShingle |
The dynamics of human cognition: increasing global integration coupled with decreasing segregation found using iEEG Cruzat Grand, Josefina, 1983- Segregation Integration CTC theory Cognition iEEG |
| title_short |
The dynamics of human cognition: increasing global integration coupled with decreasing segregation found using iEEG |
| title_full |
The dynamics of human cognition: increasing global integration coupled with decreasing segregation found using iEEG |
| title_fullStr |
The dynamics of human cognition: increasing global integration coupled with decreasing segregation found using iEEG |
| title_full_unstemmed |
The dynamics of human cognition: increasing global integration coupled with decreasing segregation found using iEEG |
| title_sort |
The dynamics of human cognition: increasing global integration coupled with decreasing segregation found using iEEG |
| dc.creator.none.fl_str_mv |
Cruzat Grand, Josefina, 1983- Deco, Gustavo Tauste Campo, Adrià, 1982- Principe, Alessandro Costa, Albert, 1970- Kringelbach, Morten L. Rocamora Zúñiga, Rodrigo Alberto |
| author |
Cruzat Grand, Josefina, 1983- |
| author_facet |
Cruzat Grand, Josefina, 1983- Deco, Gustavo Tauste Campo, Adrià, 1982- Principe, Alessandro Costa, Albert, 1970- Kringelbach, Morten L. Rocamora Zúñiga, Rodrigo Alberto |
| author_role |
author |
| author2 |
Deco, Gustavo Tauste Campo, Adrià, 1982- Principe, Alessandro Costa, Albert, 1970- Kringelbach, Morten L. Rocamora Zúñiga, Rodrigo Alberto |
| author2_role |
author author author author author author |
| dc.subject.none.fl_str_mv |
Segregation Integration CTC theory Cognition iEEG |
| topic |
Segregation Integration CTC theory Cognition iEEG |
| description |
Cognitive processing requires the ability to flexibly integrate and process information across large brain networks. How do brain networks dynamically reorganize to allow broad communication between many different brain regions in order to integrate information? We record neural activity from 12 epileptic patients using intracranial EEG while performing three cognitive tasks. We assess how the functional connectivity between different brain areas changes to facilitate communication across them. At the topological level, this facilitation is characterized by measures of integration and segregation. Across all patients, we found significant increases in integration and decreases in segregation during cognitive processing, especially in the gamma band (50–90 Hz). We also found higher levels of global synchronization and functional connectivity during task execution, again particularly in the gamma band. More importantly, functional connectivity modulations were not caused by changes in the level of the underlying oscillations. Instead, these modulations were caused by a rearrangement of the mutual synchronization between the different nodes as proposed by the “Communication Through Coherence” Theory. |
| publishDate |
2018 |
| dc.date.none.fl_str_mv |
2018 2021 2021 |
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info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion |
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article |
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acceptedVersion |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/10230/47938 http://dx.doi.org/10.1016/j.neuroimage.2018.01.064 |
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http://hdl.handle.net/10230/47938 http://dx.doi.org/10.1016/j.neuroimage.2018.01.064 |
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Inglés |
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Inglés |
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Neuroimage. 2018 May 15;172:492-505 info:eu-repo/grantAgreement/EC/H2020/295129 info:eu-repo/grantAgreement/ES/1PE/PSI2013-42091-P info:eu-repo/grantAgreement/EC/FP7/615539 |
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© Elsevier http://dx.doi.org/10.1016/j.neuroimage.2018.01.064 info:eu-repo/semantics/openAccess |
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© Elsevier http://dx.doi.org/10.1016/j.neuroimage.2018.01.064 |
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openAccess |
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application/pdf application/pdf |
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Elsevier |
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Elsevier |
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reponame:Repositorio Digital de la UPF instname:Universitat Pompeu Fabra |
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Universitat Pompeu Fabra |
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Repositorio Digital de la UPF |
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