Solid-phase peptide synthesis using N-alpha-trityl-amino acids
The preparation of Nα-trityl-amino acids is described. Several derivatives of trifunctional amino acids carrying acid- and base-labile side-chain protecting groups and the trityl group at the Nα position are prepared for first time. The incorporation of Nαtrityl-amino acids into peptide sequences us...
| Autores: | , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión aceptada para publicación |
| Fecha de publicación: | 2002 |
| País: | España |
| Institución: | Consejo Superior de Investigaciones Científicas (CSIC) |
| Repositorio: | DIGITAL.CSIC. Repositorio Institucional del CSIC |
| OAI Identifier: | oai:digital.csic.es:10261/122938 |
| Acceso en línea: | http://hdl.handle.net/10261/122938 |
| Access Level: | acceso abierto |
| Palabra clave: | Amino acid derivatives Amino protection N-trityl-amino acids Protecting Group Solid phase peptide synthesis |
| Sumario: | The preparation of Nα-trityl-amino acids is described. Several derivatives of trifunctional amino acids carrying acid- and base-labile side-chain protecting groups and the trityl group at the Nα position are prepared for first time. The incorporation of Nαtrityl-amino acids into peptide sequences using solid-phase protocols was achieved. The use of the trityl group for the protection of the α-amino group in conjunction with base-labile side-chain protecting groups constitutes a new method for the assembly of peptides in mild conditions. |
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