Caspase 8/10 are not mediating apoptosis in neuroblastoma cells treated with CDK inhibitory drugs

Olomoucine and Roscovitine are pharmacological inhibitors of cyclin-dependent kinases (CDK) displaying a promising profile as anticancer agents. Both compounds are effective inductors of apoptosis in a human neuroblastoma cell line, SH-SY5Y. The characterization of this process had suggested the inv...

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Autores: Ribas i Fortuny, Judit, Gómez Arbonés, Javier, Boix Torras, Jacint
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2005
País:España
Institución:Universitat de Lleida (UdL)
Repositorio:Repositori Obert UdL
OAI Identifier:oai:repositori.udl.cat:10459.1/48115
Acceso en línea:https://doi.org/10.1016/j.ejphar.2005.09.021
http://hdl.handle.net/10459.1/48115
Access Level:acceso abierto
Palabra clave:Apoptosis
Cell Cycle
Caspases
Roscovitine
Olomoucine
Apoptosi
Cicle cel·lular
Cell cycle
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spelling Caspase 8/10 are not mediating apoptosis in neuroblastoma cells treated with CDK inhibitory drugsRibas i Fortuny, JuditGómez Arbonés, JavierBoix Torras, JacintApoptosisCell CycleCaspasesRoscovitineOlomoucineApoptosiCicle cel·lularApoptosisCell cycleOlomoucine and Roscovitine are pharmacological inhibitors of cyclin-dependent kinases (CDK) displaying a promising profile as anticancer agents. Both compounds are effective inductors of apoptosis in a human neuroblastoma cell line, SH-SY5Y. The characterization of this process had suggested the involvement of an extrinsic pathway [Ribas, J., Boix, J., 2004. Cell differentiation, Caspase inhibition, and macromolecular synthesis blockage, but not Bcl-2 or Bcl-XL proteins, protect SH-SY5Y cells from apoptosis triggered by two CDK inhibitory drugs. Exp. Cell Res. 295 9<br>24.], which depends on either Caspase 8 or Caspase 10 activation. However, neither Caspase 8 nor Caspase 10 is expressed in SH- SY5Y cells because of gene silencing. Upon Olomoucine or Roscovitine treatment, no re-expression of Caspase 8 or Caspase 10 was found. Therefore, in SH-SY5Y cells, this type of drugs is not triggering a canonical, Caspase 8/10-mediated, extrinsic apoptotic pathway. © 2005 Elsevier B.V. All rights reserved.Elsevier2005info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfhttps://doi.org/10.1016/j.ejphar.2005.09.021http://hdl.handle.net/10459.1/48115reponame:Repositori Obert UdL instname:Universitat de Lleida (UdL)InglésVersió postprint del document publicat a: https://doi.org/10.1016/j.ejphar.2005.09.021European Journal of Pharmacology, 2005, vol. 524, num. 1-3, p. 49-52(c) Elsevier, 2005info:eu-repo/semantics/openAccessoai:repositori.udl.cat:10459.1/481152026-06-24T12:42:17Z
dc.title.none.fl_str_mv Caspase 8/10 are not mediating apoptosis in neuroblastoma cells treated with CDK inhibitory drugs
title Caspase 8/10 are not mediating apoptosis in neuroblastoma cells treated with CDK inhibitory drugs
spellingShingle Caspase 8/10 are not mediating apoptosis in neuroblastoma cells treated with CDK inhibitory drugs
Ribas i Fortuny, Judit
Apoptosis
Cell Cycle
Caspases
Roscovitine
Olomoucine
Apoptosi
Cicle cel·lular
Apoptosis
Cell cycle
title_short Caspase 8/10 are not mediating apoptosis in neuroblastoma cells treated with CDK inhibitory drugs
title_full Caspase 8/10 are not mediating apoptosis in neuroblastoma cells treated with CDK inhibitory drugs
title_fullStr Caspase 8/10 are not mediating apoptosis in neuroblastoma cells treated with CDK inhibitory drugs
title_full_unstemmed Caspase 8/10 are not mediating apoptosis in neuroblastoma cells treated with CDK inhibitory drugs
title_sort Caspase 8/10 are not mediating apoptosis in neuroblastoma cells treated with CDK inhibitory drugs
dc.creator.none.fl_str_mv Ribas i Fortuny, Judit
Gómez Arbonés, Javier
Boix Torras, Jacint
author Ribas i Fortuny, Judit
author_facet Ribas i Fortuny, Judit
Gómez Arbonés, Javier
Boix Torras, Jacint
author_role author
author2 Gómez Arbonés, Javier
Boix Torras, Jacint
author2_role author
author
dc.subject.none.fl_str_mv Apoptosis
Cell Cycle
Caspases
Roscovitine
Olomoucine
Apoptosi
Cicle cel·lular
Apoptosis
Cell cycle
topic Apoptosis
Cell Cycle
Caspases
Roscovitine
Olomoucine
Apoptosi
Cicle cel·lular
Apoptosis
Cell cycle
description Olomoucine and Roscovitine are pharmacological inhibitors of cyclin-dependent kinases (CDK) displaying a promising profile as anticancer agents. Both compounds are effective inductors of apoptosis in a human neuroblastoma cell line, SH-SY5Y. The characterization of this process had suggested the involvement of an extrinsic pathway [Ribas, J., Boix, J., 2004. Cell differentiation, Caspase inhibition, and macromolecular synthesis blockage, but not Bcl-2 or Bcl-XL proteins, protect SH-SY5Y cells from apoptosis triggered by two CDK inhibitory drugs. Exp. Cell Res. 295 9<br>24.], which depends on either Caspase 8 or Caspase 10 activation. However, neither Caspase 8 nor Caspase 10 is expressed in SH- SY5Y cells because of gene silencing. Upon Olomoucine or Roscovitine treatment, no re-expression of Caspase 8 or Caspase 10 was found. Therefore, in SH-SY5Y cells, this type of drugs is not triggering a canonical, Caspase 8/10-mediated, extrinsic apoptotic pathway. © 2005 Elsevier B.V. All rights reserved.
publishDate 2005
dc.date.none.fl_str_mv 2005
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.1016/j.ejphar.2005.09.021
http://hdl.handle.net/10459.1/48115
url https://doi.org/10.1016/j.ejphar.2005.09.021
http://hdl.handle.net/10459.1/48115
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Versió postprint del document publicat a: https://doi.org/10.1016/j.ejphar.2005.09.021
European Journal of Pharmacology, 2005, vol. 524, num. 1-3, p. 49-52
dc.rights.none.fl_str_mv (c) Elsevier, 2005
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) Elsevier, 2005
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositori Obert UdL
instname:Universitat de Lleida (UdL)
instname_str Universitat de Lleida (UdL)
reponame_str Repositori Obert UdL
collection Repositori Obert UdL
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.81155

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