Estimations of topographically correct regeneration to nerve branches and skin after peripheral nerve injury and repair.

Peripheral nerve injury is typically associated with long-term disturbances in sensory localization, despite nerve repair and regeneration. Here, we investigate the extent of correct reinnervation by back-labeling neuronal soma with fluorescent tracers applied in the target area before and after sci...

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Autores: Puigdellívol Sánchez, Anna, Prats Galino, Alberto, Molander, Carl
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2006
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/58385
Acceso en línea:https://hdl.handle.net/2445/58385
Access Level:acceso abierto
Palabra clave:Nervis perifèrics
Pell
Neurones motores
Regeneració del sistema nerviós
Rates (Animals de laboratori)
Peripheral nerves
Skin
Motor neurons
Nervous system regeneration
Rats as laboratory animals
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spelling Estimations of topographically correct regeneration to nerve branches and skin after peripheral nerve injury and repair.Puigdellívol Sánchez, AnnaPrats Galino, AlbertoMolander, CarlNervis perifèricsPellNeurones motoresRegeneració del sistema nerviósRates (Animals de laboratori)Peripheral nervesSkinMotor neuronsNervous system regenerationRats as laboratory animalsPeripheral nerve injury is typically associated with long-term disturbances in sensory localization, despite nerve repair and regeneration. Here, we investigate the extent of correct reinnervation by back-labeling neuronal soma with fluorescent tracers applied in the target area before and after sciatic nerve injury and repair in the rat. The subpopulations of sensory or motor neurons that had regenerated their axons to either the tibial branch or the skin of the third hindlimb digit were calculated from the number of cell bodies labeled by the first and/or second tracer. Compared to the normal control side, 81% of the sensory and 66% of the motor tibial nerve cells regenerated their axons back to this nerve, while 22% of the afferent cells from the third digit reinnervated this digit. Corresponding percentages based on quantification of the surviving population on the experimental side showed 91%, 87%, and 56%, respectively. The results show that nerve injury followed by nerve repair by epineurial suture results in a high but variable amount of topographically correct regeneration, and that proportionally more neurons regenerate into the correct proximal nerve branch than into the correct innervation territory in the skinElsevier B.V.2006info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfhttps://hdl.handle.net/2445/58385Articles publicats en revistes (Fonaments Clínics)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésVersió postprint del document publicat a: http://dx.doi.org/10.1016/j.brainres.2006.04.077Brain Research, 2006, vol. 1098 , num. 1, p. 49 -60http://dx.doi.org/10.1016/j.brainres.2006.04.077(c) Elsevier B.V., 2006info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/583852026-05-27T06:46:51Z
dc.title.none.fl_str_mv Estimations of topographically correct regeneration to nerve branches and skin after peripheral nerve injury and repair.
title Estimations of topographically correct regeneration to nerve branches and skin after peripheral nerve injury and repair.
spellingShingle Estimations of topographically correct regeneration to nerve branches and skin after peripheral nerve injury and repair.
Puigdellívol Sánchez, Anna
Nervis perifèrics
Pell
Neurones motores
Regeneració del sistema nerviós
Rates (Animals de laboratori)
Peripheral nerves
Skin
Motor neurons
Nervous system regeneration
Rats as laboratory animals
title_short Estimations of topographically correct regeneration to nerve branches and skin after peripheral nerve injury and repair.
title_full Estimations of topographically correct regeneration to nerve branches and skin after peripheral nerve injury and repair.
title_fullStr Estimations of topographically correct regeneration to nerve branches and skin after peripheral nerve injury and repair.
title_full_unstemmed Estimations of topographically correct regeneration to nerve branches and skin after peripheral nerve injury and repair.
title_sort Estimations of topographically correct regeneration to nerve branches and skin after peripheral nerve injury and repair.
dc.creator.none.fl_str_mv Puigdellívol Sánchez, Anna
Prats Galino, Alberto
Molander, Carl
author Puigdellívol Sánchez, Anna
author_facet Puigdellívol Sánchez, Anna
Prats Galino, Alberto
Molander, Carl
author_role author
author2 Prats Galino, Alberto
Molander, Carl
author2_role author
author
dc.subject.none.fl_str_mv Nervis perifèrics
Pell
Neurones motores
Regeneració del sistema nerviós
Rates (Animals de laboratori)
Peripheral nerves
Skin
Motor neurons
Nervous system regeneration
Rats as laboratory animals
topic Nervis perifèrics
Pell
Neurones motores
Regeneració del sistema nerviós
Rates (Animals de laboratori)
Peripheral nerves
Skin
Motor neurons
Nervous system regeneration
Rats as laboratory animals
description Peripheral nerve injury is typically associated with long-term disturbances in sensory localization, despite nerve repair and regeneration. Here, we investigate the extent of correct reinnervation by back-labeling neuronal soma with fluorescent tracers applied in the target area before and after sciatic nerve injury and repair in the rat. The subpopulations of sensory or motor neurons that had regenerated their axons to either the tibial branch or the skin of the third hindlimb digit were calculated from the number of cell bodies labeled by the first and/or second tracer. Compared to the normal control side, 81% of the sensory and 66% of the motor tibial nerve cells regenerated their axons back to this nerve, while 22% of the afferent cells from the third digit reinnervated this digit. Corresponding percentages based on quantification of the surviving population on the experimental side showed 91%, 87%, and 56%, respectively. The results show that nerve injury followed by nerve repair by epineurial suture results in a high but variable amount of topographically correct regeneration, and that proportionally more neurons regenerate into the correct proximal nerve branch than into the correct innervation territory in the skin
publishDate 2006
dc.date.none.fl_str_mv 2006
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/58385
url https://hdl.handle.net/2445/58385
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Versió postprint del document publicat a: http://dx.doi.org/10.1016/j.brainres.2006.04.077
Brain Research, 2006, vol. 1098 , num. 1, p. 49 -60
http://dx.doi.org/10.1016/j.brainres.2006.04.077
dc.rights.none.fl_str_mv (c) Elsevier B.V., 2006
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) Elsevier B.V., 2006
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier B.V.
publisher.none.fl_str_mv Elsevier B.V.
dc.source.none.fl_str_mv Articles publicats en revistes (Fonaments Clínics)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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